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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Afold [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Afold
MCC 0.765 > 0.743
Average MCC ± 95% Confidence Intervals 0.693 ± 0.766 < 0.773 ± 0.344
Sensitivity 0.710 < 0.720
Positive Predictive Value 0.835 > 0.779
Total TP 66 < 67
Total TN 3661 > 3654
Total FP 14 < 22
Total FP CONTRA 2 < 4
Total FP INCONS 11 < 15
Total FP COMP 1 < 3
Total FN 27 > 26
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Afold).

  2. Comparison of performance of Multilign(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Afold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Afold).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Afold).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 66
Total TN 3661
Total FP 14
Total FP CONTRA 2
Total FP INCONS 11
Total FP COMP 1
Total FN 27
Total Scores
MCC 0.765
Average MCC ± 95% Confidence Intervals 0.693 ± 0.766
Sensitivity 0.710
Positive Predictive Value 0.835
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3W3S_B 0.92 0.88 0.97 29 1959 2 0 1 1 4

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 67
Total TN 3654
Total FP 22
Total FP CONTRA 4
Total FP INCONS 15
Total FP COMP 3
Total FN 26
Total Scores
MCC 0.743
Average MCC ± 95% Confidence Intervals 0.773 ± 0.344
Sensitivity 0.720
Positive Predictive Value 0.779
Nr of predictions 4

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 6 0 5 1 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3W3S_B 0.55 0.55 0.56 18 1957 15 4 10 1 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.