CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Carnac(20)
MCC 0.732 > 0.608
Average MCC ± 95% Confidence Intervals 0.755 ± 0.236 > 0.517 ± 0.434
Sensitivity 0.682 > 0.434
Positive Predictive Value 0.793 < 0.862
Total TP 88 > 56
Total TN 9456 < 9502
Total FP 25 > 11
Total FP CONTRA 8 > 3
Total FP INCONS 15 > 6
Total FP COMP 2 = 2
Total FN 41 < 73
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

  2. Comparison of performance of Multilign(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 88
Total TN 9456
Total FP 25
Total FP CONTRA 8
Total FP INCONS 15
Total FP COMP 2
Total FN 41
Total Scores
MCC 0.732
Average MCC ± 95% Confidence Intervals 0.755 ± 0.236
Sensitivity 0.682
Positive Predictive Value 0.793
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3ZEX_C 0.50 0.45 0.57 13 5351 11 3 7 1 16
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 56
Total TN 9502
Total FP 11
Total FP CONTRA 3
Total FP INCONS 6
Total FP COMP 2
Total FN 73
Total Scores
MCC 0.608
Average MCC ± 95% Confidence Intervals 0.517 ± 0.434
Sensitivity 0.434
Positive Predictive Value 0.862
Nr of predictions 5

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.00 0.00 0.00 0 357 0 0 0 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
3ZEX_C 0.37 0.21 0.67 6 5365 4 1 2 1 23
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.