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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Multilign(20)
MCC 0.795 > 0.768
Average MCC ± 95% Confidence Intervals 0.818 ± 0.233 > 0.795 ± 0.307
Sensitivity 0.750 = 0.750
Positive Predictive Value 0.852 > 0.798
Total TP 75 = 75
Total TN 4105 > 4099
Total FP 14 < 21
Total FP CONTRA 5 < 7
Total FP INCONS 8 < 12
Total FP COMP 1 < 2
Total FN 25 = 25
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Multilign(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4105
Total FP 14
Total FP CONTRA 5
Total FP INCONS 8
Total FP COMP 1
Total FN 25
Total Scores
MCC 0.795
Average MCC ± 95% Confidence Intervals 0.818 ± 0.233
Sensitivity 0.750
Positive Predictive Value 0.852
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 75
Total TN 4099
Total FP 21
Total FP CONTRA 7
Total FP INCONS 12
Total FP COMP 2
Total FN 25
Total Scores
MCC 0.768
Average MCC ± 95% Confidence Intervals 0.795 ± 0.307
Sensitivity 0.750
Positive Predictive Value 0.798
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.