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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Multilign(seed) NanoFolder
MCC 0.660 > 0.333
Average MCC ± 95% Confidence Intervals 0.541 ± 1.246 > 0.367 ± 0.447
Sensitivity 0.600 > 0.375
Positive Predictive Value 0.738 > 0.323
Total TP 48 > 30
Total TN 3889 > 3861
Total FP 19 < 65
Total FP CONTRA 3 < 7
Total FP INCONS 14 < 56
Total FP COMP 2 = 2
Total FN 32 < 50
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and NanoFolder).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 48
Total TN 3889
Total FP 19
Total FP CONTRA 3
Total FP INCONS 14
Total FP COMP 2
Total FN 32
Total Scores
MCC 0.660
Average MCC ± 95% Confidence Intervals 0.541 ± 1.246
Sensitivity 0.600
Positive Predictive Value 0.738
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3W3S_B 0.92 0.88 0.97 29 1959 2 0 1 1 4
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 30
Total TN 3861
Total FP 65
Total FP CONTRA 7
Total FP INCONS 56
Total FP COMP 2
Total FN 50
Total Scores
MCC 0.333
Average MCC ± 95% Confidence Intervals 0.367 ± 0.447
Sensitivity 0.375
Positive Predictive Value 0.323
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
3W3S_B 0.18 0.21 0.18 7 1949 34 2 31 1 26
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.