CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RDfolder [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RDfolder
MCC 0.737 > 0.483
Average MCC ± 95% Confidence Intervals 0.694 ± 0.392 > 0.490 ± 0.412
Sensitivity 0.689 > 0.430
Positive Predictive Value 0.800 > 0.565
Total TP 104 > 65
Total TN 6580 < 6595
Total FP 28 < 52
Total FP CONTRA 7 < 9
Total FP INCONS 19 < 41
Total FP COMP 2 = 2
Total FN 47 < 86
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RDfolder).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 104
Total TN 6580
Total FP 28
Total FP CONTRA 7
Total FP INCONS 19
Total FP COMP 2
Total FN 47
Total Scores
MCC 0.737
Average MCC ± 95% Confidence Intervals 0.694 ± 0.392
Sensitivity 0.689
Positive Predictive Value 0.800
Nr of predictions 6

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3W3S_B 0.92 0.88 0.97 29 1959 2 0 1 1 4
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 65
Total TN 6595
Total FP 52
Total FP CONTRA 9
Total FP INCONS 41
Total FP COMP 2
Total FN 86
Total Scores
MCC 0.483
Average MCC ± 95% Confidence Intervals 0.490 ± 0.412
Sensitivity 0.430
Positive Predictive Value 0.565
Nr of predictions 6

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A -0.03 0.00 0.00 0 514 14 3 11 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.35 0.24 0.54 7 1520 6 1 5 0 22
3W3S_B 0.29 0.27 0.33 9 1962 18 2 16 0 24
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.