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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RNAalifold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RNAalifold(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RNAalifold(20)
MCC 0.732 > 0.708
Average MCC ± 95% Confidence Intervals 0.755 ± 0.236 > 0.695 ± 0.240
Sensitivity 0.682 > 0.651
Positive Predictive Value 0.793 > 0.778
Total TP 88 > 84
Total TN 9456 < 9459
Total FP 25 < 32
Total FP CONTRA 8 > 6
Total FP INCONS 15 < 18
Total FP COMP 2 < 8
Total FN 41 < 45
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RNAalifold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RNAalifold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RNAalifold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RNAalifold(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 88
Total TN 9456
Total FP 25
Total FP CONTRA 8
Total FP INCONS 15
Total FP COMP 2
Total FN 41
Total Scores
MCC 0.732
Average MCC ± 95% Confidence Intervals 0.755 ± 0.236
Sensitivity 0.682
Positive Predictive Value 0.793
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
3ZEX_C 0.50 0.45 0.57 13 5351 11 3 7 1 16
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of RNAalifold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 84
Total TN 9459
Total FP 32
Total FP CONTRA 6
Total FP INCONS 18
Total FP COMP 8
Total FN 45
Total Scores
MCC 0.708
Average MCC ± 95% Confidence Intervals 0.695 ± 0.240
Sensitivity 0.651
Positive Predictive Value 0.778
Nr of predictions 5

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.51 0.50 0.56 9 341 8 0 7 1 9
3RKF_A 0.81 0.71 0.94 17 848 1 0 1 0 7
3SD1_A 0.84 0.86 0.83 25 1503 5 4 1 0 4
3ZEX_C 0.46 0.41 0.52 12 5351 16 2 9 5 17
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.