CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Murlet(20) Carnac(seed)
MCC 0.671 > 0.220
Average MCC ± 95% Confidence Intervals 0.650 ± 0.092 > 0.087 ± 0.125
Sensitivity 0.566 > 0.049
Positive Predictive Value 0.802 < 1.000
Total TP 325 > 28
Total TN 50381 < 50758
Total FP 130 > 1
Total FP CONTRA 20 > 0
Total FP INCONS 60 > 0
Total FP COMP 50 > 1
Total FN 249 < 546
P-value 5.02343278931e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

  2. Comparison of performance of Murlet(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Carnac(seed)).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 325
Total TN 50381
Total FP 130
Total FP CONTRA 20
Total FP INCONS 60
Total FP COMP 50
Total FN 249
Total Scores
MCC 0.671
Average MCC ± 95% Confidence Intervals 0.650 ± 0.092
Sensitivity 0.566
Positive Predictive Value 0.802
Nr of predictions 23

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.70 0.50 1.00 5 169 0 0 0 0 5
2L94_A 0.51 0.50 0.56 9 341 8 0 7 1 9
2XKV_B 0.60 0.36 1.00 4 1831 3 0 0 3 7
2XXA_G 0.44 0.20 1.00 7 2038 0 0 0 0 28
3GX2_A 0.73 0.54 1.00 15 1434 1 0 0 1 13
3IVN_B 0.80 0.65 1.00 15 888 0 0 0 0 8
3IZF_C 0.88 0.83 0.94 29 2609 5 0 2 3 6
3JYX_4 0.72 0.75 0.69 9 4743 15 3 1 11 3
3JYX_3 0.76 0.73 0.79 11 2364 14 0 3 11 4
3LA5_A 0.80 0.64 1.00 16 938 0 0 0 0 9
3NPB_A 0.65 0.43 1.00 16 2262 2 0 0 2 21
3O58_3 0.37 0.32 0.44 7 4748 13 4 5 4 15
3O58_2 1.00 1.00 1.00 31 2723 2 0 0 2 0
3PDR_A 0.84 0.76 0.93 38 4799 3 1 2 0 12
3RKF_A 0.81 0.67 1.00 16 850 0 0 0 0 8
3SD1_A 0.82 0.83 0.83 24 1504 5 4 1 0 5
3ZEX_C 0.42 0.38 0.48 11 5351 16 2 10 4 18
4A1C_3 0.72 0.59 0.88 22 2738 4 0 3 1 15
4A1C_2 0.22 0.25 0.20 5 4491 24 5 15 4 15
4AOB_A 0.87 0.76 1.00 22 1415 3 0 0 3 7
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.19 0.17 0.25 4 1186 12 1 11 0 20

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 28
Total TN 50758
Total FP 1
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 1
Total FN 546
Total Scores
MCC 0.220
Average MCC ± 95% Confidence Intervals 0.087 ± 0.125
Sensitivity 0.049
Positive Predictive Value 1.000
Nr of predictions 23

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2XKV_B 0.00 0.00 0.00 0 1835 0 0 0 0 11
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IZF_C 0.00 0.00 0.00 0 2640 0 0 0 0 35
3JYX_4 0.00 0.00 0.00 0 4756 0 0 0 0 12
3JYX_3 0.00 0.00 0.00 0 2378 0 0 0 0 15
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3O58_2 0.00 0.00 0.00 0 2754 0 0 0 0 31
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.