CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & Cylofold [.zip] - may take several seconds...


Overview

Metric Murlet(20) Cylofold
MCC 0.739 > 0.715
Average MCC ± 95% Confidence Intervals 0.698 ± 0.105 < 0.735 ± 0.117
Sensitivity 0.645 < 0.713
Positive Predictive Value 0.854 > 0.725
Total TP 315 < 348
Total TN 35305 > 35194
Total FP 80 < 173
Total FP CONTRA 11 < 41
Total FP INCONS 43 < 91
Total FP COMP 26 < 41
Total FN 173 > 140
P-value 7.36344111049e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  2. Comparison of performance of Murlet(20) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Cylofold).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 315
Total TN 35305
Total FP 80
Total FP CONTRA 11
Total FP INCONS 43
Total FP COMP 26
Total FN 173
Total Scores
MCC 0.739
Average MCC ± 95% Confidence Intervals 0.698 ± 0.105
Sensitivity 0.645
Positive Predictive Value 0.854
Nr of predictions 19

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.51 0.50 0.56 9 341 8 0 7 1 9
2XKV_B 0.60 0.36 1.00 4 1831 3 0 0 3 7
2XQD_Y 0.88 0.86 0.90 18 1109 3 0 2 1 3
2XXA_G 0.44 0.20 1.00 7 2038 0 0 0 0 28
3AMU_B 0.89 0.89 0.89 17 1138 4 0 2 2 2
3IZF_C 0.88 0.83 0.94 29 2609 5 0 2 3 6
3J20_0 0.65 0.62 0.68 13 1200 6 1 5 0 8
3J20_1 0.69 0.60 0.80 12 1097 4 0 3 1 8
3J2L_3 0.84 0.74 0.96 25 2994 4 0 1 3 9
3O58_3 0.37 0.32 0.44 7 4748 13 4 5 4 15
3O58_2 1.00 1.00 1.00 31 2723 2 0 0 2 0
3PDR_A 0.84 0.76 0.93 38 4799 3 1 2 0 12
3RKF_A 0.81 0.67 1.00 16 850 0 0 0 0 8
3SD1_A 0.82 0.83 0.83 24 1504 5 4 1 0 5
3ZEX_D 0.90 0.86 0.94 30 2764 5 0 2 3 5
4AOB_A 0.87 0.76 1.00 22 1415 3 0 0 3 7
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.19 0.17 0.25 4 1186 12 1 11 0 20

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 348
Total TN 35194
Total FP 173
Total FP CONTRA 41
Total FP INCONS 91
Total FP COMP 41
Total FN 140
Total Scores
MCC 0.715
Average MCC ± 95% Confidence Intervals 0.735 ± 0.117
Sensitivity 0.713
Positive Predictive Value 0.725
Nr of predictions 19

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2XKV_B 0.41 0.55 0.32 6 1816 25 9 4 12 5
2XQD_Y 0.89 0.95 0.83 20 1105 5 4 0 1 1
2XXA_G 0.10 0.11 0.11 4 2009 32 2 30 0 31
3AMU_B 0.77 0.79 0.75 15 1137 8 0 5 3 4
3IZF_C 0.85 0.83 0.88 29 2607 7 0 4 3 6
3J20_0 0.74 0.76 0.73 16 1197 7 3 3 1 5
3J20_1 0.71 0.75 0.68 15 1090 8 2 5 1 5
3J2L_3 0.71 0.68 0.74 23 2989 11 0 8 3 11
3O58_3 0.42 0.50 0.35 11 4733 30 9 11 10 11
3O58_2 0.90 0.84 0.96 26 2727 3 0 1 2 5
3PDR_A 0.86 0.78 0.95 39 4799 4 1 1 2 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
3ZEX_D 0.69 0.69 0.71 24 2762 11 5 5 1 11
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.93 0.88 1.00 21 1181 0 0 0 0 3

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.