CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & RDfolder [.zip] - may take several seconds...


Overview

Metric Murlet(seed) RDfolder
MCC 0.642 > 0.633
Average MCC ± 95% Confidence Intervals 0.634 ± 0.086 < 0.641 ± 0.165
Sensitivity 0.494 < 0.582
Positive Predictive Value 0.850 > 0.707
Total TP 221 < 260
Total TN 18077 > 17969
Total FP 45 < 113
Total FP CONTRA 4 < 23
Total FP INCONS 35 < 85
Total FP COMP 6 > 5
Total FN 226 > 187
P-value 0.00102881663438

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Performance plots


  1. Comparison of performance of Murlet(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and RDfolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and RDfolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and RDfolder).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 221
Total TN 18077
Total FP 45
Total FP CONTRA 4
Total FP INCONS 35
Total FP COMP 6
Total FN 226
Total Scores
MCC 0.642
Average MCC ± 95% Confidence Intervals 0.634 ± 0.086
Sensitivity 0.494
Positive Predictive Value 0.850
Nr of predictions 21

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.54 0.30 1.00 3 171 0 0 0 0 7
2KE6_A 0.67 0.56 0.83 10 455 2 0 2 0 8
2KUR_A 0.65 0.53 0.83 10 455 2 0 2 0 9
2KUU_A 0.67 0.56 0.83 10 435 2 0 2 0 8
2KUV_A 0.91 0.84 1.00 16 423 0 0 0 0 3
2KUW_A 0.88 0.83 0.94 15 454 2 0 1 1 3
2L1F_A 0.83 0.78 0.90 18 743 2 0 2 0 5
2L1F_B 0.82 0.75 0.90 18 771 2 0 2 0 6
2L94_A 0.57 0.39 0.88 7 349 2 0 1 1 11
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
2XKV_B 0.60 0.36 1.00 4 1831 2 0 0 2 7
3A3A_A 0.63 0.40 1.00 12 1488 0 0 0 0 18
3GX2_A 0.70 0.50 1.00 14 1435 1 0 0 1 14
3IVN_B 0.62 0.52 0.75 12 887 4 2 2 0 11
3LA5_A 0.67 0.56 0.82 14 937 3 1 2 0 11
3RKF_A 0.62 0.50 0.80 12 851 3 1 2 0 12
3SD1_A 0.56 0.38 0.85 11 1520 2 0 2 0 18
3W3S_B 0.45 0.27 0.75 9 1977 3 0 3 0 24
4AOB_A 0.69 0.48 1.00 14 1423 1 0 0 1 15
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 260
Total TN 17969
Total FP 113
Total FP CONTRA 23
Total FP INCONS 85
Total FP COMP 5
Total FN 187
Total Scores
MCC 0.633
Average MCC ± 95% Confidence Intervals 0.641 ± 0.165
Sensitivity 0.582
Positive Predictive Value 0.707
Nr of predictions 21

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.91 0.83 1.00 15 452 1 0 0 1 3
2KUR_A 0.91 0.84 1.00 16 451 0 0 0 0 3
2KUU_A 0.91 0.83 1.00 15 432 1 0 0 1 3
2KUV_A 0.91 0.84 1.00 16 423 0 0 0 0 3
2KUW_A 0.94 0.89 1.00 16 454 0 0 0 0 2
2L1F_A -0.02 0.00 0.00 0 750 13 2 11 0 23
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A -0.03 0.00 0.00 0 514 14 3 11 0 18
2XKV_B -0.01 0.00 0.00 0 1813 22 10 12 0 11
3A3A_A 0.59 0.50 0.71 15 1479 6 0 6 0 15
3GX2_A 0.60 0.57 0.64 16 1424 10 2 7 1 12
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.35 0.24 0.54 7 1520 6 1 5 0 22
3W3S_B 0.29 0.27 0.33 9 1962 18 2 16 0 24
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 0.48 0.40 0.60 6 462 4 0 4 0 9
4ENC_A 0.48 0.40 0.60 6 486 4 0 4 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.