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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(seed) - scored higher in this pairwise comparison

  4. Performance of RSpredict(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(seed) & RSpredict(20) [.zip] - may take several seconds...


Overview

Metric Murlet(seed) RSpredict(20)
MCC 0.554 > 0.507
Average MCC ± 95% Confidence Intervals 0.552 ± 0.056 > 0.484 ± 0.138
Sensitivity 0.349 < 0.445
Positive Predictive Value 0.886 > 0.588
Total TP 171 < 218
Total TN 47561 > 47383
Total FP 36 < 205
Total FP CONTRA 4 < 66
Total FP INCONS 18 < 87
Total FP COMP 14 < 52
Total FN 319 > 272
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of Murlet(seed) and RSpredict(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and RSpredict(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(20)).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 171
Total TN 47561
Total FP 36
Total FP CONTRA 4
Total FP INCONS 18
Total FP COMP 14
Total FN 319
Total Scores
MCC 0.554
Average MCC ± 95% Confidence Intervals 0.552 ± 0.056
Sensitivity 0.349
Positive Predictive Value 0.886
Nr of predictions 21

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.54 0.30 1.00 3 171 0 0 0 0 7
2L94_A 0.57 0.39 0.88 7 349 2 0 1 1 11
2XKV_B 0.60 0.36 1.00 4 1831 2 0 0 2 7
2XXA_G 0.41 0.17 1.00 6 2039 0 0 0 0 29
3GX2_A 0.70 0.50 1.00 14 1435 1 0 0 1 14
3IVN_B 0.62 0.52 0.75 12 887 4 2 2 0 11
3J3E_8 0.36 0.13 1.00 2 2740 2 0 0 2 13
3J3F_8 0.61 0.37 1.00 7 4754 0 0 0 0 12
3JYX_4 0.50 0.25 1.00 3 4753 4 0 0 4 9
3LA5_A 0.67 0.56 0.82 14 937 3 1 2 0 11
3NPB_A 0.59 0.35 1.00 13 2265 2 0 0 2 24
3O58_3 0.52 0.27 1.00 6 4758 1 0 0 1 16
3PDR_A 0.53 0.28 1.00 14 4826 0 0 0 0 36
3RKF_A 0.62 0.50 0.80 12 851 3 1 2 0 12
3SD1_A 0.56 0.38 0.85 11 1520 2 0 2 0 18
3ZEX_C 0.49 0.24 1.00 7 5367 0 0 0 0 22
4A1C_2 0.59 0.35 1.00 7 4509 0 0 0 0 13
4AOB_A 0.69 0.48 1.00 14 1423 1 0 0 1 15
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.17 0.13 0.25 3 1190 9 0 9 0 21

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Performance of RSpredict(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 218
Total TN 47383
Total FP 205
Total FP CONTRA 66
Total FP INCONS 87
Total FP COMP 52
Total FN 272
Total Scores
MCC 0.507
Average MCC ± 95% Confidence Intervals 0.484 ± 0.138
Sensitivity 0.445
Positive Predictive Value 0.588
Nr of predictions 21

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.89 0.80 1.00 8 166 0 0 0 0 2
2L94_A 0.53 0.50 0.60 9 342 7 0 6 1 9
2XKV_B 0.00 0.00 0.00 0 1831 4 1 3 0 11
2XXA_G 0.50 0.26 1.00 9 2036 0 0 0 0 26
3GX2_A 0.40 0.21 0.75 6 1441 2 1 1 0 22
3IVN_B 0.91 0.87 0.95 20 882 1 1 0 0 3
3J3E_8 -0.01 0.00 0.00 0 2724 19 5 13 1 15
3J3F_8 0.42 0.47 0.38 9 4737 26 9 6 11 10
3JYX_4 0.59 0.75 0.47 9 4737 33 9 1 23 3
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A -0.01 0.00 0.00 0 2272 6 1 5 0 37
3O58_3 0.38 0.50 0.30 11 4727 29 15 11 3 11
3PDR_A 0.80 0.70 0.92 35 4802 5 1 2 2 15
3RKF_A 0.91 0.88 0.95 21 844 1 1 0 0 3
3SD1_A 0.82 0.86 0.78 25 1501 7 5 2 0 4
3ZEX_C 0.34 0.31 0.38 9 5350 19 3 12 4 20
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9
4FRG_B 0.19 0.13 0.33 3 1193 6 1 5 0 21

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.