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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_2.0(seed) - scored higher in this pairwise comparison

  4. Performance of CentroidAlifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_2.0(seed) & CentroidAlifold(seed) [.zip] - may take several seconds...


Overview

Metric PETfold_2.0(seed) CentroidAlifold(seed)
MCC 0.866 > 0.756
Average MCC ± 95% Confidence Intervals 0.868 ± 0.471 > 0.738 ± 1.570
Sensitivity 0.845 > 0.638
Positive Predictive Value 0.891 < 0.902
Total TP 49 > 37
Total TN 4279 < 4293
Total FP 19 > 9
Total FP CONTRA 2 > 1
Total FP INCONS 4 > 3
Total FP COMP 13 > 5
Total FN 9 < 21
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_2.0(seed) and CentroidAlifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_2.0(seed) and CentroidAlifold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_2.0(seed) and CentroidAlifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_2.0(seed) and CentroidAlifold(seed)).

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Performance of PETfold_2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_2.0(seed)

Total Base Pair Counts
Total TP 49
Total TN 4279
Total FP 19
Total FP CONTRA 2
Total FP INCONS 4
Total FP COMP 13
Total FN 9
Total Scores
MCC 0.866
Average MCC ± 95% Confidence Intervals 0.868 ± 0.471
Sensitivity 0.845
Positive Predictive Value 0.891
Nr of predictions 2

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2. Individual counts for PETfold_2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3V_B 0.90 0.89 0.92 24 2630 14 0 2 12 3
3W1K_J 0.83 0.81 0.86 25 1649 5 2 2 1 6

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Performance of CentroidAlifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 37
Total TN 4293
Total FP 9
Total FP CONTRA 1
Total FP INCONS 3
Total FP COMP 5
Total FN 21
Total Scores
MCC 0.756
Average MCC ± 95% Confidence Intervals 0.738 ± 1.570
Sensitivity 0.638
Positive Predictive Value 0.902
Nr of predictions 2

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J3V_B 0.61 0.44 0.86 12 2642 7 0 2 5 15
3W1K_J 0.86 0.81 0.93 25 1651 2 1 1 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.