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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of MXScarna(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & MXScarna(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) MXScarna(20)
MCC 0.793 > 0.697
Average MCC ± 95% Confidence Intervals 0.752 ± 0.129 > 0.661 ± 0.127
Sensitivity 0.776 > 0.680
Positive Predictive Value 0.815 > 0.721
Total TP 339 > 297
Total TN 41984 < 41988
Total FP 145 < 211
Total FP CONTRA 14 < 39
Total FP INCONS 63 < 76
Total FP COMP 68 < 96
Total FN 98 < 140
P-value 2.54914456376e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  2. Comparison of performance of PETfold_pre2.0(20) and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MXScarna(20)).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 339
Total TN 41984
Total FP 145
Total FP CONTRA 14
Total FP INCONS 63
Total FP COMP 68
Total FN 98
Total Scores
MCC 0.793
Average MCC ± 95% Confidence Intervals 0.752 ± 0.129
Sensitivity 0.776
Positive Predictive Value 0.815
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 1.00 1.00 1.00 20 1092 1 0 0 1 0
3J20_0 0.95 0.95 0.95 20 1198 1 1 0 0 1
3J2L_3 0.97 0.94 1.00 32 2988 4 0 0 4 2
3J3D_C 0.87 0.89 0.85 17 948 3 3 0 0 2
3J3E_8 0.48 0.47 0.50 7 2728 11 2 5 4 8
3J3E_7 0.94 0.94 0.94 32 2707 7 0 2 5 2
3J3F_8 0.34 0.37 0.32 7 4739 24 5 10 9 12
3J3F_7 0.93 0.92 0.94 33 2899 6 0 2 4 3
3J3V_B 0.90 0.89 0.92 24 2630 11 0 2 9 3
3ZEX_D 0.93 0.91 0.94 32 2762 6 0 2 4 3
3ZEX_C 0.26 0.24 0.29 7 5350 20 1 16 3 22
3ZND_W 0.67 0.75 0.60 6 1181 15 0 4 11 2
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4A1C_3 1.00 1.00 1.00 37 2726 1 0 0 1 0
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7
4FRG_B 0.89 0.83 0.95 20 1181 2 0 1 1 4

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Performance of MXScarna(20) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 297
Total TN 41988
Total FP 211
Total FP CONTRA 39
Total FP INCONS 76
Total FP COMP 96
Total FN 140
Total Scores
MCC 0.697
Average MCC ± 95% Confidence Intervals 0.661 ± 0.127
Sensitivity 0.680
Positive Predictive Value 0.721
Nr of predictions 18

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.97 0.95 1.00 19 1093 1 0 0 1 1
3J20_0 0.93 0.90 0.95 19 1199 1 1 0 0 2
3J2L_3 0.67 0.65 0.71 22 2989 11 3 6 2 12
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.21 0.20 0.23 3 2729 15 4 6 5 12
3J3E_7 0.80 0.82 0.78 28 2705 14 1 7 6 6
3J3F_8 0.48 0.53 0.43 10 4738 29 7 6 16 9
3J3F_7 0.82 0.83 0.81 30 2897 12 1 6 5 6
3J3V_B 1.00 1.00 1.00 27 2629 12 0 0 12 0
3ZEX_D 0.85 0.83 0.88 29 2763 13 0 4 9 6
3ZEX_C 0.35 0.31 0.41 9 5352 15 3 10 2 20
3ZND_W 0.58 0.75 0.46 6 1178 17 4 3 10 2
4A1C_2 0.22 0.25 0.21 5 4492 36 8 11 17 15
4A1C_3 0.80 0.78 0.83 29 2728 12 0 6 6 8
4AOB_A 0.68 0.69 0.69 20 1408 13 2 7 4 9
4ENB_A 0.29 0.13 0.67 2 469 1 0 1 0 13
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8
4FRG_B 0.65 0.58 0.74 14 1183 6 2 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.