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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & Murlet(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) Murlet(20)
MCC 0.793 > 0.682
Average MCC ± 95% Confidence Intervals 0.752 ± 0.129 > 0.645 ± 0.117
Sensitivity 0.776 > 0.611
Positive Predictive Value 0.815 > 0.767
Total TP 339 > 267
Total TN 41984 < 42052
Total FP 145 > 129
Total FP CONTRA 14 < 16
Total FP INCONS 63 < 65
Total FP COMP 68 > 48
Total FN 98 < 170
P-value 3.18846395401e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Murlet(20)).

  2. Comparison of performance of PETfold_pre2.0(20) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Murlet(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Murlet(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Murlet(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Murlet(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Murlet(20)).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 339
Total TN 41984
Total FP 145
Total FP CONTRA 14
Total FP INCONS 63
Total FP COMP 68
Total FN 98
Total Scores
MCC 0.793
Average MCC ± 95% Confidence Intervals 0.752 ± 0.129
Sensitivity 0.776
Positive Predictive Value 0.815
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 1.00 1.00 1.00 20 1092 1 0 0 1 0
3J20_0 0.95 0.95 0.95 20 1198 1 1 0 0 1
3J2L_3 0.97 0.94 1.00 32 2988 4 0 0 4 2
3J3D_C 0.87 0.89 0.85 17 948 3 3 0 0 2
3J3E_8 0.48 0.47 0.50 7 2728 11 2 5 4 8
3J3E_7 0.94 0.94 0.94 32 2707 7 0 2 5 2
3J3F_8 0.34 0.37 0.32 7 4739 24 5 10 9 12
3J3F_7 0.93 0.92 0.94 33 2899 6 0 2 4 3
3J3V_B 0.90 0.89 0.92 24 2630 11 0 2 9 3
3ZEX_D 0.93 0.91 0.94 32 2762 6 0 2 4 3
3ZEX_C 0.26 0.24 0.29 7 5350 20 1 16 3 22
3ZND_W 0.67 0.75 0.60 6 1181 15 0 4 11 2
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4A1C_3 1.00 1.00 1.00 37 2726 1 0 0 1 0
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7
4FRG_B 0.89 0.83 0.95 20 1181 2 0 1 1 4

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 267
Total TN 42052
Total FP 129
Total FP CONTRA 16
Total FP INCONS 65
Total FP COMP 48
Total FN 170
Total Scores
MCC 0.682
Average MCC ± 95% Confidence Intervals 0.645 ± 0.117
Sensitivity 0.611
Positive Predictive Value 0.767
Nr of predictions 18

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.69 0.60 0.80 12 1097 4 0 3 1 8
3J20_0 0.65 0.62 0.68 13 1200 6 1 5 0 8
3J2L_3 0.84 0.74 0.96 25 2994 4 0 1 3 9
3J3D_C 0.84 0.84 0.84 16 949 3 3 0 0 3
3J3E_8 0.35 0.33 0.38 5 2729 13 2 6 5 10
3J3E_7 0.97 0.94 1.00 32 2709 4 0 0 4 2
3J3F_8 0.54 0.53 0.56 10 4743 13 2 6 5 9
3J3F_7 0.83 0.69 1.00 25 2909 1 0 0 1 11
3J3V_B 0.88 0.78 1.00 21 2635 2 0 0 2 6
3ZEX_D 0.90 0.86 0.94 30 2764 5 0 2 3 5
3ZEX_C 0.42 0.38 0.48 11 5351 16 2 10 4 18
3ZND_W 0.62 0.63 0.63 5 1183 15 0 3 12 3
4A1C_2 0.22 0.25 0.20 5 4491 24 5 15 4 15
4A1C_3 0.72 0.59 0.88 22 2738 4 0 3 1 15
4AOB_A 0.87 0.76 1.00 22 1415 3 0 0 3 7
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.19 0.17 0.25 4 1186 12 1 11 0 20

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.