CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Carnac(20)
MCC 0.887 > 0.665
Average MCC ± 95% Confidence Intervals 0.851 ± 0.067 > 0.575 ± 0.152
Sensitivity 0.858 > 0.515
Positive Predictive Value 0.919 > 0.865
Total TP 375 > 225
Total TN 41992 < 42140
Total FP 123 > 63
Total FP CONTRA 11 > 7
Total FP INCONS 22 < 28
Total FP COMP 90 > 28
Total FN 62 < 212
P-value 2.7402423548e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  2. Comparison of performance of PETfold_pre2.0(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Carnac(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 375
Total TN 41992
Total FP 123
Total FP CONTRA 11
Total FP INCONS 22
Total FP COMP 90
Total FN 62
Total Scores
MCC 0.887
Average MCC ± 95% Confidence Intervals 0.851 ± 0.067
Sensitivity 0.858
Positive Predictive Value 0.919
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 1.00 1.00 1.00 20 1092 2 0 0 2 0
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J2L_3 0.97 0.94 1.00 32 2988 5 0 0 5 2
3J3D_C 0.90 0.95 0.86 18 947 4 3 0 1 1
3J3E_8 0.71 0.67 0.77 10 2729 8 1 2 5 5
3J3E_7 0.97 0.97 0.97 33 2707 6 0 1 5 1
3J3F_8 0.86 0.84 0.89 16 4743 13 2 0 11 3
3J3F_7 0.99 0.97 1.00 35 2899 4 0 0 4 1
3J3V_B 0.90 0.89 0.92 24 2630 14 0 2 12 3
3ZEX_D 0.96 0.94 0.97 33 2762 6 0 1 5 2
3ZEX_C 0.70 0.59 0.85 17 5354 12 1 2 9 12
3ZND_W 0.67 0.75 0.60 6 1181 16 0 4 12 2
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4A1C_3 1.00 1.00 1.00 37 2726 2 0 0 2 0
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7
4FRG_B 0.87 0.83 0.91 20 1180 3 0 2 1 4

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 225
Total TN 42140
Total FP 63
Total FP CONTRA 7
Total FP INCONS 28
Total FP COMP 28
Total FN 212
Total Scores
MCC 0.665
Average MCC ± 95% Confidence Intervals 0.575 ± 0.152
Sensitivity 0.515
Positive Predictive Value 0.865
Nr of predictions 18

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.89 0.80 1.00 16 1096 1 0 0 1 4
3J20_0 0.69 0.71 0.68 15 1197 8 1 6 1 6
3J2L_3 0.59 0.53 0.67 18 2993 11 0 9 2 16
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3E_7 0.84 0.71 1.00 24 2717 1 0 0 1 10
3J3F_8 0.61 0.37 1.00 7 4754 2 0 0 2 12
3J3F_7 0.78 0.61 1.00 22 2912 0 0 0 0 14
3J3V_B 0.82 0.67 1.00 18 2638 3 0 0 3 9
3ZEX_D 0.81 0.66 1.00 23 2773 3 0 0 3 12
3ZEX_C 0.37 0.21 0.67 6 5365 4 1 2 1 23
3ZND_W 0.75 0.75 0.75 6 1183 13 0 2 11 2
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4A1C_3 0.79 0.73 0.87 27 2732 5 0 4 1 10
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.50 0.25 1.00 6 1196 0 0 0 0 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.