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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Mastr(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Mastr(20)
MCC 0.887 > 0.577
Average MCC ± 95% Confidence Intervals 0.851 ± 0.067 > 0.431 ± 0.191
Sensitivity 0.858 > 0.471
Positive Predictive Value 0.919 > 0.715
Total TP 375 > 206
Total TN 41992 < 42112
Total FP 123 > 109
Total FP CONTRA 11 < 16
Total FP INCONS 22 < 66
Total FP COMP 90 > 27
Total FN 62 < 231
P-value 3.07760058607e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

  2. Comparison of performance of PETfold_pre2.0(seed) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Mastr(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 375
Total TN 41992
Total FP 123
Total FP CONTRA 11
Total FP INCONS 22
Total FP COMP 90
Total FN 62
Total Scores
MCC 0.887
Average MCC ± 95% Confidence Intervals 0.851 ± 0.067
Sensitivity 0.858
Positive Predictive Value 0.919
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 1.00 1.00 1.00 20 1092 2 0 0 2 0
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J2L_3 0.97 0.94 1.00 32 2988 5 0 0 5 2
3J3D_C 0.90 0.95 0.86 18 947 4 3 0 1 1
3J3E_8 0.71 0.67 0.77 10 2729 8 1 2 5 5
3J3E_7 0.97 0.97 0.97 33 2707 6 0 1 5 1
3J3F_8 0.86 0.84 0.89 16 4743 13 2 0 11 3
3J3F_7 0.99 0.97 1.00 35 2899 4 0 0 4 1
3J3V_B 0.90 0.89 0.92 24 2630 14 0 2 12 3
3ZEX_D 0.96 0.94 0.97 33 2762 6 0 1 5 2
3ZEX_C 0.70 0.59 0.85 17 5354 12 1 2 9 12
3ZND_W 0.67 0.75 0.60 6 1181 16 0 4 12 2
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4A1C_3 1.00 1.00 1.00 37 2726 2 0 0 2 0
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7
4FRG_B 0.87 0.83 0.91 20 1180 3 0 2 1 4

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 206
Total TN 42112
Total FP 109
Total FP CONTRA 16
Total FP INCONS 66
Total FP COMP 27
Total FN 231
Total Scores
MCC 0.577
Average MCC ± 95% Confidence Intervals 0.431 ± 0.191
Sensitivity 0.471
Positive Predictive Value 0.715
Nr of predictions 18

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.26 0.25 0.29 5 1095 12 1 11 0 15
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J2L_3 0.42 0.38 0.48 13 2993 16 2 12 2 21
3J3D_C 0.90 0.95 0.86 18 947 3 3 0 0 1
3J3E_8 0.00 0.00 0.00 0 2742 0 0 0 0 15
3J3E_7 0.84 0.85 0.83 29 2706 12 1 5 6 5
3J3F_8 0.00 0.00 0.00 0 4761 0 0 0 0 19
3J3F_7 0.89 0.89 0.89 32 2898 8 1 3 4 4
3J3V_B 0.27 0.26 0.30 7 2633 16 1 15 0 20
3ZEX_D 0.93 0.91 0.94 32 2762 7 0 2 5 3
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
3ZND_W -0.01 0.00 0.00 0 1180 16 5 6 5 8
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4A1C_3 0.88 0.86 0.89 32 2727 7 0 4 3 5
4AOB_A 0.42 0.34 0.53 10 1418 10 1 8 1 19
4ENB_A 0.44 0.20 1.00 3 469 0 0 0 0 12
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.