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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Murlet(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Murlet(20)
MCC 0.887 > 0.682
Average MCC ± 95% Confidence Intervals 0.851 ± 0.067 > 0.645 ± 0.117
Sensitivity 0.858 > 0.611
Positive Predictive Value 0.919 > 0.767
Total TP 375 > 267
Total TN 41992 < 42052
Total FP 123 < 129
Total FP CONTRA 11 < 16
Total FP INCONS 22 < 65
Total FP COMP 90 > 48
Total FN 62 < 170
P-value 2.48055519165e-08

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  2. Comparison of performance of PETfold_pre2.0(seed) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Murlet(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 375
Total TN 41992
Total FP 123
Total FP CONTRA 11
Total FP INCONS 22
Total FP COMP 90
Total FN 62
Total Scores
MCC 0.887
Average MCC ± 95% Confidence Intervals 0.851 ± 0.067
Sensitivity 0.858
Positive Predictive Value 0.919
Nr of predictions 18

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 1.00 1.00 1.00 20 1092 2 0 0 2 0
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J2L_3 0.97 0.94 1.00 32 2988 5 0 0 5 2
3J3D_C 0.90 0.95 0.86 18 947 4 3 0 1 1
3J3E_8 0.71 0.67 0.77 10 2729 8 1 2 5 5
3J3E_7 0.97 0.97 0.97 33 2707 6 0 1 5 1
3J3F_8 0.86 0.84 0.89 16 4743 13 2 0 11 3
3J3F_7 0.99 0.97 1.00 35 2899 4 0 0 4 1
3J3V_B 0.90 0.89 0.92 24 2630 14 0 2 12 3
3ZEX_D 0.96 0.94 0.97 33 2762 6 0 1 5 2
3ZEX_C 0.70 0.59 0.85 17 5354 12 1 2 9 12
3ZND_W 0.67 0.75 0.60 6 1181 16 0 4 12 2
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4A1C_3 1.00 1.00 1.00 37 2726 2 0 0 2 0
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7
4FRG_B 0.87 0.83 0.91 20 1180 3 0 2 1 4

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 267
Total TN 42052
Total FP 129
Total FP CONTRA 16
Total FP INCONS 65
Total FP COMP 48
Total FN 170
Total Scores
MCC 0.682
Average MCC ± 95% Confidence Intervals 0.645 ± 0.117
Sensitivity 0.611
Positive Predictive Value 0.767
Nr of predictions 18

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_1 0.69 0.60 0.80 12 1097 4 0 3 1 8
3J20_0 0.65 0.62 0.68 13 1200 6 1 5 0 8
3J2L_3 0.84 0.74 0.96 25 2994 4 0 1 3 9
3J3D_C 0.84 0.84 0.84 16 949 3 3 0 0 3
3J3E_8 0.35 0.33 0.38 5 2729 13 2 6 5 10
3J3E_7 0.97 0.94 1.00 32 2709 4 0 0 4 2
3J3F_8 0.54 0.53 0.56 10 4743 13 2 6 5 9
3J3F_7 0.83 0.69 1.00 25 2909 1 0 0 1 11
3J3V_B 0.88 0.78 1.00 21 2635 2 0 0 2 6
3ZEX_D 0.90 0.86 0.94 30 2764 5 0 2 3 5
3ZEX_C 0.42 0.38 0.48 11 5351 16 2 10 4 18
3ZND_W 0.62 0.63 0.63 5 1183 15 0 3 12 3
4A1C_2 0.22 0.25 0.20 5 4491 24 5 15 4 15
4A1C_3 0.72 0.59 0.88 22 2738 4 0 3 1 15
4AOB_A 0.87 0.76 1.00 22 1415 3 0 0 3 7
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10
4FRG_B 0.19 0.17 0.25 4 1186 12 1 11 0 20

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.