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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric PPfold(20) CMfinder(20)
MCC 0.927 > 0.652
Average MCC ± 95% Confidence Intervals 0.922 ± 0.091 > 0.662 ± 0.224
Sensitivity 0.895 > 0.518
Positive Predictive Value 0.962 > 0.831
Total TP 102 > 59
Total TN 8131 < 8166
Total FP 12 < 16
Total FP CONTRA 1 < 3
Total FP INCONS 3 < 9
Total FP COMP 8 > 4
Total FN 12 < 55
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and CMfinder(20)).

  2. Comparison of performance of PPfold(20) and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and CMfinder(20)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 102
Total TN 8131
Total FP 12
Total FP CONTRA 1
Total FP INCONS 3
Total FP COMP 8
Total FN 12
Total Scores
MCC 0.927
Average MCC ± 95% Confidence Intervals 0.922 ± 0.091
Sensitivity 0.895
Positive Predictive Value 0.962
Nr of predictions 4

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.95 0.95 0.95 20 1198 1 1 0 0 1
3J2L_3 0.97 0.94 1.00 32 2988 4 0 0 4 2
3ZEX_D 0.93 0.91 0.94 32 2762 6 0 2 4 3
4FRG_B 0.84 0.75 0.95 18 1183 1 0 1 0 6

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 59
Total TN 8166
Total FP 16
Total FP CONTRA 3
Total FP INCONS 9
Total FP COMP 4
Total FN 55
Total Scores
MCC 0.652
Average MCC ± 95% Confidence Intervals 0.662 ± 0.224
Sensitivity 0.518
Positive Predictive Value 0.831
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J2L_3 0.57 0.50 0.65 17 2994 11 2 7 2 17
3ZEX_D 0.70 0.54 0.90 19 2775 3 0 2 1 16
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.