CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of RNASampler(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & RNASampler(20) [.zip] - may take several seconds...


Overview

Metric PPfold(20) RNASampler(20)
MCC 0.812 > 0.741
Average MCC ± 95% Confidence Intervals 0.784 ± 0.124 > 0.750 ± 0.125
Sensitivity 0.753 > 0.669
Positive Predictive Value 0.880 > 0.826
Total TP 278 > 247
Total TN 28004 < 28021
Total FP 59 < 83
Total FP CONTRA 4 < 10
Total FP INCONS 34 < 42
Total FP COMP 21 < 31
Total FN 91 < 122
P-value 2.89169006118e-08

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Performance plots


  1. Comparison of performance of PPfold(20) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and RNASampler(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(20) and RNASampler(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and RNASampler(20)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 278
Total TN 28004
Total FP 59
Total FP CONTRA 4
Total FP INCONS 34
Total FP COMP 21
Total FN 91
Total Scores
MCC 0.812
Average MCC ± 95% Confidence Intervals 0.784 ± 0.124
Sensitivity 0.753
Positive Predictive Value 0.880
Nr of predictions 15

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.66 0.50 0.90 9 347 1 0 1 0 9
3AMU_B 1.00 1.00 1.00 19 1138 2 0 0 2 0
3J20_1 1.00 1.00 1.00 20 1092 1 0 0 1 0
3J20_0 0.95 0.95 0.95 20 1198 1 1 0 0 1
3J2L_3 0.97 0.94 1.00 32 2988 4 0 0 4 2
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
3ZEX_C 0.38 0.31 0.47 9 5355 14 0 10 4 20
3ZEX_D 0.93 0.91 0.94 32 2762 6 0 2 4 3
4A1C_3 0.93 0.92 0.94 34 2727 2 0 2 0 3
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7
4FRG_B 0.84 0.75 0.95 18 1183 1 0 1 0 6

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 247
Total TN 28021
Total FP 83
Total FP CONTRA 10
Total FP INCONS 42
Total FP COMP 31
Total FN 122
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.750 ± 0.125
Sensitivity 0.669
Positive Predictive Value 0.826
Nr of predictions 15

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
3AMU_B 0.95 0.95 0.95 18 1138 4 0 1 3 1
3J20_1 1.00 1.00 1.00 20 1092 1 0 0 1 0
3J20_0 0.90 0.90 0.90 19 1198 3 1 1 1 2
3J2L_3 0.56 0.50 0.63 17 2993 12 3 7 2 17
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.81 0.69 0.95 20 1512 1 0 1 0 9
3ZEX_C 0.35 0.31 0.39 9 5351 21 3 11 7 20
3ZEX_D 0.83 0.69 1.00 24 2772 1 0 0 1 11
4A1C_3 0.90 0.81 1.00 30 2733 0 0 0 0 7
4A1C_2 0.24 0.25 0.24 5 4495 30 3 13 14 15
4AOB_A 0.70 0.59 0.85 17 1417 4 0 3 1 12
4ENB_A 0.68 0.47 1.00 7 465 0 0 0 0 8
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4
4FRG_B 0.64 0.54 0.76 13 1185 4 0 4 0 11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.