CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PknotsRG - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for PknotsRG & MCFold [.zip] - may take several seconds...


Overview

Metric PknotsRG MCFold
MCC 0.757 > 0.622
Average MCC ± 95% Confidence Intervals 0.782 ± 0.050 > 0.657 ± 0.062
Sensitivity 0.781 > 0.663
Positive Predictive Value 0.742 > 0.597
Total TP 1698 > 1441
Total TN 133918 > 133792
Total FP 883 < 1310
Total FP CONTRA 175 < 262
Total FP INCONS 416 < 712
Total FP COMP 292 < 336
Total FN 477 < 734
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of PknotsRG and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and MCFold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PknotsRG and MCFold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and MCFold).

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Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP 1698
Total TN 133918
Total FP 883
Total FP CONTRA 175
Total FP INCONS 416
Total FP COMP 292
Total FN 477
Total Scores
MCC 0.757
Average MCC ± 95% Confidence Intervals 0.782 ± 0.050
Sensitivity 0.781
Positive Predictive Value 0.742
Nr of predictions 131

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.88 0.89 0.89 16 449 3 0 2 1 2
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.77 0.88 0.70 7 226 3 2 1 0 1
2KGP_A - 0.69 0.67 0.75 6 113 2 0 2 0 3
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KU0_A - 0.96 0.92 1.00 11 281 0 0 0 0 1
2KUR_A 0.89 0.89 0.89 17 448 2 0 2 0 2
2KUU_A 0.88 0.89 0.89 16 429 3 0 2 1 2
2KUV_A 0.89 0.89 0.89 17 420 2 0 2 0 2
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.93 0.88 1.00 7 142 0 0 0 0 1
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.66 0.61 0.73 11 513 4 2 2 0 7
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.81 0.86 0.76 25 2407 10 6 2 2 4
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LU0_A - 1.00 1.00 1.00 16 422 0 0 0 0 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2M58_A - 0.96 1.00 0.92 12 531 1 1 0 0 0
2RP0_A - 0.87 1.00 0.78 7 107 2 2 0 0 0
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 14 0 0 14 1
2WW9_F - 0.64 0.75 0.60 6 102 4 1 3 0 2
2WW9_D - 0.08 0.10 0.08 1 729 15 2 9 4 9
2WW9_E - 0.89 0.80 1.00 4 168 0 0 0 0 1
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 24 0 6 18 3
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.35 0.34 0.38 12 2013 21 1 19 1 23
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2YIE_X - 0.43 0.57 0.33 4 532 10 2 6 2 3
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZN_D 0.93 0.95 0.91 21 961 2 2 0 0 1
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3AKZ_H 0.46 0.50 0.43 10 1104 15 6 7 2 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 137 3 0 3 0 6
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.80 0.79 0.81 22 1422 6 2 3 1 6
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.54 0.60 0.50 3 223 6 1 2 3 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.21 0.21 0.24 6 1447 19 1 18 0 22
3IZF_C 0.75 0.77 0.73 27 2603 15 0 10 5 8
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_2 - 0.29 0.31 0.29 8 2222 27 2 18 7 18
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_7 - 0.38 0.50 0.31 5 503 12 3 8 1 5
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_a - 0.18 0.18 0.22 2 402 8 3 4 1 9
3J16_L 0.90 0.81 1.00 17 1142 0 0 0 0 4
3J20_0 0.51 0.57 0.48 12 1194 14 3 10 1 9
3J2L_3 0.80 0.82 0.78 28 2984 12 1 7 4 6
3J3D_C 0.63 0.68 0.59 13 946 9 3 6 0 6
3J3E_8 0.26 0.33 0.21 5 2718 30 6 13 11 10
3J3E_7 0.77 0.76 0.79 26 2708 11 1 6 4 8
3J3F_7 0.96 0.97 0.95 35 2897 4 1 1 2 1
3J3F_8 0.32 0.42 0.24 8 4728 40 12 13 15 11
3JYV_7 -0.02 0.00 0.00 0 1089 22 4 18 0 20
3JYX_3 0.77 0.80 0.75 12 2362 27 0 4 23 3
3JYX_4 0.61 0.83 0.45 10 4734 33 10 2 21 2
3KTW_C - 1.00 1.00 1.00 25 1755 7 0 0 7 0
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3O58_2 0.72 0.74 0.70 23 2721 19 0 10 9 8
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3ZEX_G - 0.70 0.71 0.70 32 6461 23 6 8 9 13
3ZEX_F - -0.01 0.00 0.00 0 908 11 2 4 5 4
3ZEX_C 0.30 0.34 0.26 10 5336 44 5 23 16 19
3ZEX_H - 0.25 0.37 0.18 7 3586 32 20 12 0 12
3ZEX_D 0.88 0.83 0.94 29 2765 6 0 2 4 6
3ZND_W 0.24 0.38 0.16 3 1172 24 9 7 8 5
4A1C_2 0.18 0.25 0.14 5 4480 43 11 20 12 15
4A1C_3 0.85 0.84 0.86 31 2727 8 0 5 3 6
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4ATO_G - 0.88 1.00 0.78 7 211 2 2 0 0 0
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FNJ_A - 0.91 0.83 1.00 10 240 0 0 0 0 2
4FRG_B 0.36 0.38 0.38 9 1178 15 2 13 0 15
4FRN_A 0.59 0.57 0.62 16 1822 10 2 8 0 12
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.88 0.92 0.85 22 1056 4 4 0 0 2
4JRC_A - 0.34 0.35 0.35 6 605 11 0 11 0 11

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 1441
Total TN 133792
Total FP 1310
Total FP CONTRA 262
Total FP INCONS 712
Total FP COMP 336
Total FN 734
Total Scores
MCC 0.622
Average MCC ± 95% Confidence Intervals 0.657 ± 0.062
Sensitivity 0.663
Positive Predictive Value 0.597
Nr of predictions 131

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 4 0 0 4 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 1 0 0 1 0
2KDQ_B 1.00 1.00 1.00 10 164 1 0 0 1 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.54 0.63 0.50 5 226 5 2 3 0 3
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 1 0 0 1 0
2KPV_A - 1.00 1.00 1.00 13 200 0 0 0 0 0
2KU0_A - 1.00 1.00 1.00 12 280 1 0 0 1 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 1 0 0 1 0
2KZL_A - 1.00 1.00 1.00 13 507 5 0 0 5 0
2L1F_A 0.79 0.78 0.82 18 741 4 0 4 0 5
2L1F_B 0.80 0.79 0.83 19 768 4 0 4 0 5
2L2K_A - 1.00 1.00 1.00 17 332 1 0 0 1 0
2L3C_B - 1.00 1.00 1.00 14 225 1 0 0 1 0
2L3E_A - 1.00 1.00 1.00 12 228 2 0 0 2 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - -0.03 0.00 0.00 0 265 10 0 10 0 7
2LBS_A - 1.00 1.00 1.00 14 193 1 0 0 1 0
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 0.95 0.91 1.00 10 152 0 0 0 0 1
2LHP_A - 1.00 1.00 1.00 15 246 1 0 0 1 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 1.00 1.00 1.00 29 2411 11 0 0 11 0
2LQZ_A - 1.00 1.00 1.00 8 124 3 0 0 3 0
2LU0_A - 1.00 1.00 1.00 16 422 2 0 0 2 0
2LWK_A - 1.00 1.00 1.00 11 196 2 0 0 2 0
2M58_A - 0.22 0.25 0.23 3 531 13 1 9 3 9
2RP0_A - 0.70 0.71 0.71 5 109 2 1 1 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 1 0 0 1 0
2WRQ_Y 0.38 0.56 0.26 5 1133 21 8 6 7 4
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_D - -0.02 0.00 0.00 0 723 21 6 12 3 10
2WW9_E - -0.03 0.00 0.00 0 165 8 1 6 1 5
2WWQ_V 0.19 0.21 0.19 4 1183 20 3 14 3 15
2XKV_B 0.20 0.27 0.16 3 1816 30 4 12 14 8
2XQD_Y 0.39 0.43 0.38 9 1105 18 2 13 3 12
2XXA_G 0.23 0.26 0.24 9 2007 30 1 28 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 2 0 0 2 0
2Y9C_V - 0.65 0.72 0.59 13 884 12 1 8 3 5
2YIE_Z - 0.53 0.63 0.45 5 591 8 2 4 2 3
2YIE_X - -0.01 0.00 0.00 0 535 15 1 8 6 7
2ZY6_A - 0.77 0.78 0.78 7 267 6 1 1 4 2
2ZZN_D 0.69 0.73 0.67 16 960 11 1 7 3 6
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3A3A_A 0.98 0.97 1.00 29 1471 0 0 0 0 1
3AKZ_H 0.46 0.50 0.43 10 1104 16 5 8 3 10
3AM1_B - 1.00 1.00 1.00 29 1437 1 0 0 1 0
3AMU_B 0.50 0.58 0.44 11 1132 15 4 10 1 8
3DW4_A - 1.00 1.00 1.00 6 134 3 0 0 3 0
3GCA_A - -0.05 0.00 0.00 0 150 8 4 4 0 7
3GX2_A 0.58 0.61 0.57 17 1419 15 1 12 2 11
3HAY_E - 1.00 1.00 1.00 14 910 10 0 0 10 0
3HJW_D - 1.00 1.00 1.00 16 593 5 0 0 5 0
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - 0.54 0.60 0.50 3 223 7 1 2 4 2
3IVN_B 0.45 0.48 0.46 11 879 14 5 8 1 12
3IWN_A 0.19 0.21 0.20 6 1442 24 5 19 0 22
3IZF_C 0.92 0.94 0.89 33 2603 10 0 4 6 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_2 - 0.25 0.27 0.25 7 2222 29 4 17 8 19
3J0L_g - -0.02 0.00 0.00 0 170 7 4 2 1 2
3J0L_7 - -0.02 0.00 0.00 0 504 15 6 9 0 10
3J0L_h - 0.98 0.97 1.00 31 2109 2 0 0 2 1
3J0L_1 - 0.88 0.85 0.92 11 472 5 0 1 4 2
3J0L_a - 0.14 0.18 0.15 2 398 13 1 10 2 9
3J16_L 0.54 0.57 0.52 12 1136 12 4 7 1 9
3J20_0 0.66 0.71 0.63 15 1195 11 3 6 2 6
3J2L_3 0.77 0.79 0.75 27 2984 15 1 8 6 7
3J3D_C 0.54 0.63 0.48 12 943 13 4 9 0 7
3J3E_8 0.15 0.20 0.12 3 2716 36 11 12 13 12
3J3E_7 0.55 0.56 0.54 19 2706 23 1 15 7 15
3J3F_7 0.88 0.89 0.86 32 2897 9 1 4 4 4
3J3F_8 0.14 0.21 0.10 4 4720 51 17 20 14 15
3JYV_7 0.25 0.30 0.24 6 1086 20 8 11 1 14
3JYX_3 0.46 0.67 0.32 10 2347 28 15 6 7 5
3JYX_4 0.36 0.58 0.23 7 4725 37 19 5 13 5
3KTW_C - 0.55 0.60 0.52 15 1751 20 4 10 6 10
3LA5_A 0.44 0.44 0.48 11 931 12 2 10 0 14
3NDB_M - 0.29 0.30 0.30 13 3671 35 1 29 5 31
3NKB_B - 0.68 0.74 0.64 14 713 8 2 6 0 5
3NMU_E - 0.51 0.67 0.40 2 211 8 1 2 5 1
3O58_3 0.28 0.36 0.22 8 4727 39 14 15 10 14
3O58_2 0.25 0.29 0.23 9 2715 31 6 24 1 22
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.78 0.80 0.77 40 4788 14 5 7 2 10
3R4F_A - 0.95 0.95 0.95 21 884 4 0 1 3 1
3R9X_C - 0.87 0.88 0.88 7 221 5 0 1 4 1
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16
3SIU_F - 0.53 0.63 0.50 5 135 5 2 3 0 3
3SN2_B 0.58 0.58 0.64 7 143 4 0 4 0 5
3TRZ_Z - -0.05 0.00 0.00 0 88 4 0 4 0 5
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - -0.05 0.00 0.00 0 102 7 0 6 1 5
3U4M_B - 0.74 0.77 0.71 17 1252 10 1 6 3 5
3VJR_D - 1.00 1.00 1.00 12 239 1 0 0 1 0
3ZEX_G - 0.00 0.00 0.00 0 6493 14 6 8 0 45
3ZEX_F - 0.00 0.00 0.00 0 909 22 0 5 17 4
3ZEX_C 0.30 0.34 0.27 10 5337 28 6 21 1 19
3ZEX_H - 0.22 0.32 0.16 6 3588 36 15 16 5 13
3ZEX_D 0.23 0.26 0.23 9 2756 33 6 25 2 26
3ZND_W 0.23 0.38 0.15 3 1171 26 9 8 9 5
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4A1C_3 0.86 0.86 0.86 32 2726 9 0 5 4 5
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4ATO_G - 0.36 0.43 0.33 3 211 8 0 6 2 4
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10
4FNJ_A - 0.91 0.92 0.92 11 238 1 0 1 0 1
4FRG_B 0.35 0.38 0.35 9 1176 17 3 14 0 15
4FRN_A 0.09 0.11 0.10 3 1818 28 2 25 1 25
4HXH_A - 1.00 1.00 1.00 6 89 0 0 0 0 0
4JF2_A 0.74 0.75 0.75 18 1058 7 1 5 1 6
4JRC_A - 0.24 0.29 0.23 5 600 17 0 17 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.