CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Carnac(seed)
MCC 0.742 > 0.220
Average MCC ± 95% Confidence Intervals 0.735 ± 0.092 > 0.087 ± 0.125
Sensitivity 0.652 > 0.049
Positive Predictive Value 0.850 < 1.000
Total TP 374 > 28
Total TN 50346 < 50758
Total FP 141 > 1
Total FP CONTRA 22 > 0
Total FP INCONS 44 > 0
Total FP COMP 75 > 1
Total FN 200 < 546
P-value 5.06544643719e-08

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Performance plots


  1. Comparison of performance of RNASampler(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  2. Comparison of performance of RNASampler(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Carnac(seed)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 374
Total TN 50346
Total FP 141
Total FP CONTRA 22
Total FP INCONS 44
Total FP COMP 75
Total FN 200
Total Scores
MCC 0.742
Average MCC ± 95% Confidence Intervals 0.735 ± 0.092
Sensitivity 0.652
Positive Predictive Value 0.850
Nr of predictions 23

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2XKV_B 0.60 0.36 1.00 4 1831 2 0 0 2 7
2XXA_G 0.34 0.11 1.00 4 2041 0 0 0 0 31
3GX2_A 0.88 0.79 1.00 22 1427 1 0 0 1 6
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZF_C 0.92 0.86 1.00 30 2610 2 0 0 2 5
3JYX_4 0.61 0.83 0.45 10 4734 26 10 2 14 2
3JYX_3 0.70 0.60 0.82 9 2367 14 0 2 12 6
3LA5_A 0.89 0.80 1.00 20 934 0 0 0 0 5
3NPB_A 0.75 0.57 1.00 21 2257 5 0 0 5 16
3O58_3 0.51 0.50 0.52 11 4743 19 5 5 9 11
3O58_2 0.93 0.87 1.00 27 2727 5 0 0 5 4
3PDR_A 0.84 0.76 0.93 38 4799 5 1 2 2 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.81 0.69 0.95 20 1512 1 0 1 0 9
3ZEX_C 0.35 0.31 0.39 9 5351 21 3 11 7 20
4A1C_3 0.90 0.81 1.00 30 2733 0 0 0 0 7
4A1C_2 0.24 0.25 0.24 5 4495 30 3 13 14 15
4AOB_A 0.70 0.59 0.85 17 1417 4 0 3 1 12
4ENB_A 0.68 0.47 1.00 7 465 0 0 0 0 8
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4
4FRG_B 0.64 0.54 0.76 13 1185 4 0 4 0 11

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 28
Total TN 50758
Total FP 1
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 1
Total FN 546
Total Scores
MCC 0.220
Average MCC ± 95% Confidence Intervals 0.087 ± 0.125
Sensitivity 0.049
Positive Predictive Value 1.000
Nr of predictions 23

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2XKV_B 0.00 0.00 0.00 0 1835 0 0 0 0 11
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IZF_C 0.00 0.00 0.00 0 2640 0 0 0 0 35
3JYX_4 0.00 0.00 0.00 0 4756 0 0 0 0 12
3JYX_3 0.00 0.00 0.00 0 2378 0 0 0 0 15
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3O58_2 0.00 0.00 0.00 0 2754 0 0 0 0 31
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.