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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(20) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(20) Mastr(seed)
MCC 0.790 > 0.000
Average MCC ± 95% Confidence Intervals 0.783 ± 0.071 > 0.000 ± 0.000
Sensitivity 0.704 > 0.000
Positive Predictive Value 0.891 > 0.000
Total TP 631 > 0
Total TN 92154 < 92862
Total FP 174 > 0
Total FP CONTRA 24 > 0
Total FP INCONS 53 > 0
Total FP COMP 97 > 0
Total FN 265 < 896
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAalifold(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Mastr(seed)).

  2. Comparison of performance of RNAalifold(20) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and Mastr(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and Mastr(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and Mastr(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Mastr(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and Mastr(seed)).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP 631
Total TN 92154
Total FP 174
Total FP CONTRA 24
Total FP INCONS 53
Total FP COMP 97
Total FN 265
Total Scores
MCC 0.790
Average MCC ± 95% Confidence Intervals 0.783 ± 0.071
Sensitivity 0.704
Positive Predictive Value 0.891
Nr of predictions 34

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.62 0.40 1.00 4 170 0 0 0 0 6
2L94_A 0.51 0.50 0.56 9 341 8 0 7 1 9
2WRQ_Y 1.00 1.00 1.00 9 1143 12 0 0 12 0
2XKV_B 0.60 0.36 1.00 4 1831 3 0 0 3 7
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.44 0.20 1.00 7 2038 0 0 0 0 28
3A2K_C 0.98 0.95 1.00 21 1087 0 0 0 0 1
3AMU_B 1.00 1.00 1.00 19 1138 2 0 0 2 0
3G4S_9 0.96 0.92 1.00 24 2712 7 0 0 7 2
3GX2_A 0.92 0.86 1.00 24 1425 1 0 0 1 4
3IVN_B 0.86 0.78 0.95 18 884 1 1 0 0 5
3IZ4_A 0.65 0.48 0.87 46 25483 15 4 3 8 49
3IZF_C 0.90 0.89 0.91 31 2606 6 0 3 3 4
3J20_0 0.95 0.95 0.95 20 1198 1 1 0 0 1
3J20_1 1.00 1.00 1.00 20 1092 1 0 0 1 0
3J2L_3 0.86 0.74 1.00 25 2995 2 0 0 2 9
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3JYX_4 0.77 0.83 0.71 10 4742 15 3 1 11 2
3JYX_3 0.76 0.73 0.79 11 2364 20 0 3 17 4
3LA5_A 0.87 0.76 1.00 19 935 0 0 0 0 6
3NPB_A 0.75 0.57 1.00 21 2257 4 0 0 4 16
3O58_2 0.97 0.94 1.00 29 2725 7 0 0 7 2
3O58_3 0.42 0.36 0.50 8 4748 9 3 5 1 14
3PDR_A 0.92 0.88 0.96 44 4794 3 1 1 1 6
3RKF_A 0.81 0.71 0.94 17 848 1 0 1 0 7
3SD1_A 0.84 0.86 0.83 25 1503 5 4 1 0 4
3ZEX_C 0.46 0.41 0.52 12 5351 16 2 9 5 17
3ZEX_D 0.91 0.89 0.94 31 2763 6 0 2 4 4
4A1C_3 0.90 0.84 0.97 31 2731 1 0 1 0 6
4A1C_2 0.22 0.25 0.19 5 4490 23 5 16 2 15
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9
4FRG_B 0.84 0.71 1.00 17 1185 0 0 0 0 7

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 92862
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 896
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 34

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.00 0.00 0.00 0 174 0 0 0 0 10
2L94_A 0.00 0.00 0.00 0 357 0 0 0 0 18
2WRQ_Y 0.00 0.00 0.00 0 1152 0 0 0 0 9
2XKV_B 0.00 0.00 0.00 0 1835 0 0 0 0 11
2XQD_Y 0.00 0.00 0.00 0 1129 0 0 0 0 21
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3A2K_C 0.00 0.00 0.00 0 1108 0 0 0 0 22
3AMU_B 0.00 0.00 0.00 0 1157 0 0 0 0 19
3G4S_9 0.00 0.00 0.00 0 2736 0 0 0 0 26
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IZ4_A 0.00 0.00 0.00 0 25536 0 0 0 0 95
3IZF_C 0.00 0.00 0.00 0 2640 0 0 0 0 35
3J20_0 0.00 0.00 0.00 0 1219 0 0 0 0 21
3J20_1 0.00 0.00 0.00 0 1112 0 0 0 0 20
3J2L_3 0.00 0.00 0.00 0 3020 0 0 0 0 34
3JYV_7 0.00 0.00 0.00 0 1111 0 0 0 0 20
3JYX_4 0.00 0.00 0.00 0 4756 0 0 0 0 12
3JYX_3 0.00 0.00 0.00 0 2378 0 0 0 0 15
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_2 0.00 0.00 0.00 0 2754 0 0 0 0 31
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3ZEX_C 0.00 0.00 0.00 0 5374 0 0 0 0 29
3ZEX_D 0.00 0.00 0.00 0 2796 0 0 0 0 35
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.