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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) NanoFolder
MCC 0.581 > 0.294
Average MCC ± 95% Confidence Intervals 0.532 ± 0.420 > 0.351 ± 0.333
Sensitivity 0.426 > 0.357
Positive Predictive Value 0.803 > 0.259
Total TP 49 > 41
Total TN 8905 > 8808
Total FP 18 < 135
Total FP CONTRA 0 < 27
Total FP INCONS 12 < 90
Total FP COMP 6 < 18
Total FN 66 < 74
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

  2. Comparison of performance of RNAalifold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 49
Total TN 8905
Total FP 18
Total FP CONTRA 0
Total FP INCONS 12
Total FP COMP 6
Total FN 66
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.532 ± 0.420
Sensitivity 0.426
Positive Predictive Value 0.803
Nr of predictions 5

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
3W3S_B 0.71 0.52 1.00 17 1972 2 0 0 2 16
4A1C_2 0.50 0.25 1.00 5 4511 2 0 0 2 15
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 41
Total TN 8808
Total FP 135
Total FP CONTRA 27
Total FP INCONS 90
Total FP COMP 18
Total FN 74
Total Scores
MCC 0.294
Average MCC ± 95% Confidence Intervals 0.351 ± 0.333
Sensitivity 0.357
Positive Predictive Value 0.259
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
3W3S_B 0.18 0.21 0.18 7 1949 34 2 31 1 26
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.