CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAsubopt - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAsubopt & Vsfold5 [.zip] - may take several seconds...


Overview

Metric RNAsubopt Vsfold5
MCC 0.722 > 0.593
Average MCC ± 95% Confidence Intervals 0.755 ± 0.055 > 0.666 ± 0.062
Sensitivity 0.743 > 0.595
Positive Predictive Value 0.709 > 0.601
Total TP 1712 > 1371
Total TN 175187 < 175318
Total FP 988 < 1089
Total FP CONTRA 219 < 260
Total FP INCONS 482 < 651
Total FP COMP 287 > 178
Total FN 593 < 934
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAsubopt and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Vsfold5).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 1712
Total TN 175187
Total FP 988
Total FP CONTRA 219
Total FP INCONS 482
Total FP COMP 287
Total FN 593
Total Scores
MCC 0.722
Average MCC ± 95% Confidence Intervals 0.755 ± 0.055
Sensitivity 0.743
Positive Predictive Value 0.709
Nr of predictions 127

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.95 0.91 1.00 10 176 0 0 0 0 1
2K63_A - 0.94 0.89 1.00 8 160 0 0 0 0 1
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 0.87 0.78 1.00 7 101 0 0 0 0 2
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.88 0.89 0.89 16 449 3 0 2 1 2
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - -0.03 0.00 0.00 0 229 7 1 6 0 8
2KGP_A - 1.00 1.00 1.00 9 112 0 0 0 0 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.62 0.61 0.64 14 2002 15 5 3 7 9
2KU0_A - 0.96 0.92 1.00 11 281 0 0 0 0 1
2KUR_A 0.89 0.89 0.89 17 448 2 0 2 0 2
2KUU_A 0.88 0.89 0.89 16 429 3 0 2 1 2
2KUV_A 0.89 0.89 0.89 17 420 2 0 2 0 2
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.95 0.91 1.00 21 742 0 0 0 0 2
2L1F_B 0.96 0.92 1.00 22 769 0 0 0 0 2
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 0.96 0.93 1.00 13 226 0 0 0 0 1
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.85 0.86 0.83 25 2410 14 0 5 9 4
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 13 0 0 13 0
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.09 0.10 0.11 1 732 13 2 6 5 9
2WW9_F - 0.52 0.63 0.50 5 102 5 1 4 0 3
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 25 0 6 19 3
2XQD_Y 0.83 0.81 0.85 17 1109 4 0 3 1 4
2XXA_G 0.49 0.49 0.52 17 2012 17 1 15 1 18
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.29 0.33 0.26 5 1339 22 5 9 8 10
2ZZN_D 0.52 0.55 0.52 12 961 11 3 8 0 10
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.43 0.45 0.43 9 1106 14 3 9 2 11
3AM1_B - 1.00 1.00 1.00 29 1437 0 0 0 0 0
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.41 0.46 0.38 12 2704 25 7 13 5 14
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.53 0.54 0.54 15 1421 14 4 9 1 13
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.97 0.94 1.00 15 594 2 0 0 2 1
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.54 0.60 0.50 3 223 5 1 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.69 0.68 0.70 19 1445 9 1 7 1 9
3IYQ_A 0.28 0.39 0.20 20 22342 96 41 37 18 31
3IZ4_A 0.56 0.60 0.53 57 25429 54 26 24 4 38
3IZF_C 0.89 0.91 0.86 32 2603 9 0 5 4 3
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_2 - 0.28 0.31 0.28 8 2221 25 2 19 4 18
3J0L_7 - -0.02 0.00 0.00 0 507 12 2 10 0 10
3J0L_g - -0.01 0.00 0.00 0 173 5 1 2 2 2
3J0L_a - 0.35 0.36 0.36 4 400 8 3 4 1 7
3J16_L 0.49 0.52 0.48 11 1136 12 3 9 0 10
3J20_0 0.51 0.57 0.48 12 1194 14 2 11 1 9
3J20_1 1.00 1.00 1.00 20 1092 3 0 0 3 0
3J2C_O - 0.66 0.68 0.65 28 3944 20 3 12 5 13
3J2L_3 0.80 0.82 0.78 28 2984 13 1 7 5 6
3JYV_7 -0.02 0.00 0.00 0 1090 21 4 17 0 20
3JYX_4 0.34 0.58 0.21 7 4722 38 20 7 11 5
3JYX_3 0.77 0.80 0.75 12 2362 26 0 4 22 3
3KTW_C - 1.00 1.00 1.00 25 1755 8 0 0 8 0
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.66 0.68 0.65 13 715 7 0 7 0 6
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.84 0.78 0.91 29 2246 8 0 3 5 8
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3O58_2 0.87 0.90 0.85 28 2721 13 0 5 8 3
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.49 0.50 0.50 8 1277 15 0 8 7 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.95 0.94 0.97 31 1957 2 0 1 1 2
3ZEX_D 0.91 0.89 0.94 31 2763 6 0 2 4 4
3ZEX_E - 0.00 0.00 0.00 0 8255 54 17 32 5 34
4A1C_3 0.85 0.84 0.86 31 2727 8 0 5 3 6
4A1C_2 0.18 0.25 0.14 5 4481 43 13 17 13 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.62 0.62 0.64 18 1409 11 4 6 1 11
4ATO_G - 0.36 0.43 0.33 3 211 6 6 0 0 4
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.36 0.33 0.42 5 484 7 0 7 0 10
4FRG_B 0.36 0.38 0.38 9 1178 15 2 13 0 15
4FRN_A 0.58 0.57 0.59 16 1821 11 3 8 0 12

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1371
Total TN 175318
Total FP 1089
Total FP CONTRA 260
Total FP INCONS 651
Total FP COMP 178
Total FN 934
Total Scores
MCC 0.593
Average MCC ± 95% Confidence Intervals 0.666 ± 0.062
Sensitivity 0.595
Positive Predictive Value 0.601
Nr of predictions 127

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 0.95 0.90 1.00 9 165 0 0 0 0 1
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 0.78 0.63 1.00 5 97 0 0 0 0 3
2KFC_A - 0.77 0.88 0.70 7 226 3 2 1 0 1
2KGP_A - 0.81 0.67 1.00 6 115 1 0 0 1 3
2KMJ_A - 0.95 0.91 1.00 10 158 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.71 0.78 0.64 18 1996 13 8 2 3 5
2KU0_A - -0.04 0.00 0.00 0 281 11 0 11 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.70 0.61 0.82 14 746 3 0 3 0 9
2L1F_B 0.71 0.63 0.83 15 773 3 0 3 0 9
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.97 0.94 1.00 17 340 1 0 0 1 1
2LA5_A - -0.03 0.00 0.00 0 268 7 0 7 0 7
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 0.94 0.89 1.00 8 92 0 0 0 0 1
2LKR_A - 0.31 0.31 0.32 9 2412 19 5 14 0 20
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 0.68 0.71 0.71 5 65 2 0 2 0 2
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.08 0.10 0.09 1 730 13 3 7 3 9
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1803 32 17 15 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2014 31 2 29 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.74 0.72 0.76 13 889 7 0 4 3 5
2YIE_X - 0.43 0.57 0.33 4 532 10 2 6 2 3
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.17 0.20 0.16 3 1339 25 4 12 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.72 0.61 0.87 20 1796 3 0 3 0 13
3AKZ_H 0.97 0.95 1.00 19 1108 1 0 0 1 1
3AM1_B - 0.86 0.86 0.86 25 1437 4 3 1 0 4
3AMU_B 0.77 0.79 0.75 15 1137 8 0 5 3 4
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.12 0.15 0.11 4 2699 33 9 24 0 22
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.50 0.56 0.47 9 590 10 2 8 0 7
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.26 0.25 0.30 7 1449 16 2 14 0 21
3IYQ_A 0.30 0.37 0.24 19 22361 71 36 24 11 32
3IZ4_A 0.31 0.31 0.33 29 25448 65 14 45 6 66
3IZF_C 0.85 0.83 0.88 29 2607 5 0 4 1 6
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_1 - 0.25 0.23 0.30 3 474 8 3 4 1 10
3J0L_h - 0.20 0.19 0.24 6 2115 19 3 16 0 26
3J0L_2 - 0.42 0.42 0.44 11 2225 21 1 13 7 15
3J0L_7 - -0.02 0.00 0.00 0 506 13 3 10 0 10
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3J20_0 0.76 0.76 0.76 16 1198 6 3 2 1 5
3J20_1 0.75 0.75 0.75 15 1092 7 0 5 2 5
3J2C_O - 0.33 0.32 0.36 13 3951 26 3 20 3 28
3J2L_3 0.70 0.71 0.71 24 2986 13 3 7 3 10
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_4 0.63 0.83 0.48 10 4735 32 9 2 21 2
3JYX_3 0.12 0.13 0.11 2 2360 20 6 10 4 13
3KTW_C - 0.46 0.44 0.50 11 1758 15 2 9 4 14
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NDB_M - 0.07 0.07 0.08 3 3678 33 2 31 0 41
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.28 0.33 0.25 1 212 5 2 1 2 2
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3O58_2 0.50 0.52 0.50 16 2722 19 3 13 3 15
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.24 0.31 0.20 5 1268 20 9 11 0 11
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.83 0.85 0.82 28 1955 7 2 4 1 5
3ZEX_D 0.09 0.09 0.12 3 2771 24 5 17 2 32
3ZEX_E - 0.11 0.15 0.09 5 8247 54 21 31 2 29
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ATO_G - 0.67 0.86 0.55 6 209 5 5 0 0 1
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4FRN_A 0.15 0.14 0.17 4 1825 19 3 16 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.