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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Sfold - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Sfold & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric Sfold CMfinder(20)
MCC 0.729 > 0.652
Average MCC ± 95% Confidence Intervals 0.707 ± 0.237 > 0.662 ± 0.224
Sensitivity 0.719 > 0.518
Positive Predictive Value 0.745 < 0.831
Total TP 82 > 59
Total TN 8127 < 8166
Total FP 38 > 16
Total FP CONTRA 7 > 3
Total FP INCONS 21 > 9
Total FP COMP 10 > 4
Total FN 32 < 55
P-value 0.0

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Performance plots


  1. Comparison of performance of Sfold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Sfold and CMfinder(20)).

  2. Comparison of performance of Sfold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Sfold and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Sfold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Sfold and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Sfold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Sfold and CMfinder(20)).

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Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP 82
Total TN 8127
Total FP 38
Total FP CONTRA 7
Total FP INCONS 21
Total FP COMP 10
Total FN 32
Total Scores
MCC 0.729
Average MCC ± 95% Confidence Intervals 0.707 ± 0.237
Sensitivity 0.719
Positive Predictive Value 0.745
Nr of predictions 4

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.51 0.57 0.48 12 1194 14 3 10 1 9
3J2L_3 0.80 0.82 0.78 28 2984 12 1 7 4 6
3ZEX_D 0.85 0.80 0.90 28 2765 8 0 3 5 7
4FRG_B 0.67 0.58 0.78 14 1184 4 3 1 0 10

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 59
Total TN 8166
Total FP 16
Total FP CONTRA 3
Total FP INCONS 9
Total FP COMP 4
Total FN 55
Total Scores
MCC 0.652
Average MCC ± 95% Confidence Intervals 0.662 ± 0.224
Sensitivity 0.518
Positive Predictive Value 0.831
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J2L_3 0.57 0.50 0.65 17 2994 11 2 7 2 17
3ZEX_D 0.70 0.54 0.90 19 2775 3 0 2 1 16
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.