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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Afold [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Afold
MCC 0.740 > 0.713
Average MCC ± 95% Confidence Intervals 0.742 ± 0.368 < 0.747 ± 0.398
Sensitivity 0.705 < 0.723
Positive Predictive Value 0.782 > 0.711
Total TP 79 < 81
Total TN 8906 > 8893
Total FP 36 < 55
Total FP CONTRA 6 < 11
Total FP INCONS 16 < 22
Total FP COMP 14 < 22
Total FN 33 > 31
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  2. Comparison of performance of TurboFold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Afold).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 79
Total TN 8906
Total FP 36
Total FP CONTRA 6
Total FP INCONS 16
Total FP COMP 14
Total FN 33
Total Scores
MCC 0.740
Average MCC ± 95% Confidence Intervals 0.742 ± 0.368
Sensitivity 0.705
Positive Predictive Value 0.782
Nr of predictions 5

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3ZEX_D 0.86 0.80 0.93 28 2766 6 0 2 4 7
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 81
Total TN 8893
Total FP 55
Total FP CONTRA 11
Total FP INCONS 22
Total FP COMP 22
Total FN 31
Total Scores
MCC 0.713
Average MCC ± 95% Confidence Intervals 0.747 ± 0.398
Sensitivity 0.723
Positive Predictive Value 0.711
Nr of predictions 5

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3ZEX_D 0.82 0.77 0.87 27 2765 8 0 4 4 8
4A1C_2 0.19 0.25 0.15 5 4483 43 11 17 15 15
4ENB_A 0.81 0.73 0.92 11 460 3 0 1 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.