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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Alterna - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Alterna [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Alterna
MCC 0.829 > 0.750
Average MCC ± 95% Confidence Intervals 0.842 ± 0.168 > 0.776 ± 0.296
Sensitivity 0.800 > 0.756
Positive Predictive Value 0.867 > 0.756
Total TP 72 > 68
Total TN 3830 > 3823
Total FP 15 < 26
Total FP CONTRA 2 < 5
Total FP INCONS 9 < 17
Total FP COMP 4 = 4
Total FN 18 < 22
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Alterna. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Alterna).

  2. Comparison of performance of TurboFold(20) and Alterna. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Alterna).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Alterna. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Alterna).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Alterna. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Alterna).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 72
Total TN 3830
Total FP 15
Total FP CONTRA 2
Total FP INCONS 9
Total FP COMP 4
Total FN 18
Total Scores
MCC 0.829
Average MCC ± 95% Confidence Intervals 0.842 ± 0.168
Sensitivity 0.800
Positive Predictive Value 0.867
Nr of predictions 4

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9

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Performance of Alterna - scored lower in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 68
Total TN 3823
Total FP 26
Total FP CONTRA 5
Total FP INCONS 17
Total FP COMP 4
Total FN 22
Total Scores
MCC 0.750
Average MCC ± 95% Confidence Intervals 0.776 ± 0.296
Sensitivity 0.756
Positive Predictive Value 0.756
Nr of predictions 4

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
3AMU_B 0.73 0.79 0.68 15 1135 10 0 7 3 4
3RKF_A 0.82 0.79 0.86 19 844 3 1 2 0 5
3SD1_A 0.55 0.55 0.57 16 1505 12 4 8 0 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.