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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric TurboFold(seed) NanoFolder
MCC 0.532 > 0.410
Average MCC ± 95% Confidence Intervals 0.485 ± 0.473 > 0.431 ± 0.328
Sensitivity 0.521 > 0.496
Positive Predictive Value 0.554 > 0.353
Total TP 62 > 59
Total TN 9628 > 9573
Total FP 65 < 125
Total FP CONTRA 15 < 34
Total FP INCONS 35 < 74
Total FP COMP 15 < 17
Total FN 57 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

  2. Comparison of performance of TurboFold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 62
Total TN 9628
Total FP 65
Total FP CONTRA 15
Total FP INCONS 35
Total FP COMP 15
Total FN 57
Total Scores
MCC 0.532
Average MCC ± 95% Confidence Intervals 0.485 ± 0.473
Sensitivity 0.521
Positive Predictive Value 0.554
Nr of predictions 5

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4A1C_3 0.86 0.84 0.89 31 2728 6 0 4 2 6
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 59
Total TN 9573
Total FP 125
Total FP CONTRA 34
Total FP INCONS 74
Total FP COMP 17
Total FN 60
Total Scores
MCC 0.410
Average MCC ± 95% Confidence Intervals 0.431 ± 0.328
Sensitivity 0.496
Positive Predictive Value 0.353
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.