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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of UNAFold - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for UNAFold & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric UNAFold CMfinder(20)
MCC 0.674 > 0.652
Average MCC ± 95% Confidence Intervals 0.639 ± 0.384 < 0.662 ± 0.224
Sensitivity 0.684 > 0.518
Positive Predictive Value 0.672 < 0.831
Total TP 78 > 59
Total TN 8121 < 8166
Total FP 47 > 16
Total FP CONTRA 6 > 3
Total FP INCONS 32 > 9
Total FP COMP 9 > 4
Total FN 36 < 55
P-value 0.0

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Performance plots


  1. Comparison of performance of UNAFold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for UNAFold and CMfinder(20)).

  2. Comparison of performance of UNAFold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for UNAFold and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for UNAFold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for UNAFold and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for UNAFold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for UNAFold and CMfinder(20)).

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Performance of UNAFold - scored higher in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 78
Total TN 8121
Total FP 47
Total FP CONTRA 6
Total FP INCONS 32
Total FP COMP 9
Total FN 36
Total Scores
MCC 0.674
Average MCC ± 95% Confidence Intervals 0.639 ± 0.384
Sensitivity 0.684
Positive Predictive Value 0.672
Nr of predictions 4

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.51 0.57 0.48 12 1194 14 3 10 1 9
3J2L_3 0.80 0.82 0.78 28 2984 12 1 7 4 6
3ZEX_D 0.88 0.83 0.94 29 2765 6 0 2 4 6
4FRG_B 0.36 0.38 0.38 9 1178 15 2 13 0 15

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 59
Total TN 8166
Total FP 16
Total FP CONTRA 3
Total FP INCONS 9
Total FP COMP 4
Total FN 55
Total Scores
MCC 0.652
Average MCC ± 95% Confidence Intervals 0.662 ± 0.224
Sensitivity 0.518
Positive Predictive Value 0.831
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.84 0.76 0.94 16 1202 2 1 0 1 5
3J2L_3 0.57 0.50 0.65 17 2994 11 2 7 2 17
3ZEX_D 0.70 0.54 0.90 19 2775 3 0 2 1 16
4FRG_B 0.54 0.29 1.00 7 1195 0 0 0 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.