CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold4 Carnac(seed)
MCC 0.616 > 0.287
Average MCC ± 95% Confidence Intervals 0.642 ± 0.121 > 0.158 ± 0.114
Sensitivity 0.601 > 0.084
Positive Predictive Value 0.642 < 1.000
Total TP 460 > 64
Total TN 52557 < 53209
Total FP 322 > 1
Total FP CONTRA 62 > 0
Total FP INCONS 194 > 0
Total FP COMP 66 > 1
Total FN 305 < 701
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Vsfold4 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  2. Comparison of performance of Vsfold4 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Carnac(seed)).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 460
Total TN 52557
Total FP 322
Total FP CONTRA 62
Total FP INCONS 194
Total FP COMP 66
Total FN 305
Total Scores
MCC 0.616
Average MCC ± 95% Confidence Intervals 0.642 ± 0.121
Sensitivity 0.601
Positive Predictive Value 0.642
Nr of predictions 32

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2L1F_A 0.67 0.57 0.81 13 747 3 0 3 0 10
2L1F_B 0.69 0.58 0.82 14 774 3 0 3 0 10
2L94_A 0.94 0.89 1.00 16 341 1 0 0 1 2
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2XKV_B -0.01 0.00 0.00 0 1808 27 13 14 0 11
2XXA_G -0.02 0.00 0.00 0 2016 29 1 28 0 35
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3GX2_A 0.60 0.57 0.64 16 1424 10 0 9 1 12
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IZF_C 0.85 0.83 0.88 29 2607 6 0 4 2 6
3JYX_4 0.19 0.25 0.15 3 4736 33 9 8 16 9
3JYX_3 0.64 0.67 0.63 10 2362 16 5 1 10 5
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.66 0.59 0.73 22 2248 10 0 8 2 15
3O58_2 0.53 0.52 0.55 16 2725 16 3 10 3 15
3O58_3 0.12 0.14 0.11 3 4737 35 8 16 11 19
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
3W3S_B 0.74 0.70 0.79 23 1960 7 1 5 1 10
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 64
Total TN 53209
Total FP 1
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 1
Total FN 701
Total Scores
MCC 0.287
Average MCC ± 95% Confidence Intervals 0.158 ± 0.114
Sensitivity 0.084
Positive Predictive Value 1.000
Nr of predictions 32

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.00 0.00 0.00 0 467 0 0 0 0 18
2KUR_A 0.60 0.37 1.00 7 460 0 0 0 0 12
2KUU_A 0.62 0.39 1.00 7 440 0 0 0 0 11
2KUV_A 0.68 0.47 1.00 9 430 0 0 0 0 10
2KUW_A 0.70 0.50 1.00 9 461 0 0 0 0 9
2L1F_A 0.00 0.00 0.00 0 763 0 0 0 0 23
2L1F_B 0.00 0.00 0.00 0 791 0 0 0 0 24
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
2XKV_B 0.00 0.00 0.00 0 1835 0 0 0 0 11
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3A3A_A 0.00 0.00 0.00 0 1500 0 0 0 0 30
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IZF_C 0.00 0.00 0.00 0 2640 0 0 0 0 35
3JYX_4 0.00 0.00 0.00 0 4756 0 0 0 0 12
3JYX_3 0.00 0.00 0.00 0 2378 0 0 0 0 15
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_2 0.00 0.00 0.00 0 2754 0 0 0 0 31
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.