CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold4 - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold4 & Vsfold5 [.zip] - may take several seconds...


Overview

Metric Vsfold4 Vsfold5
MCC 0.638 > 0.598
Average MCC ± 95% Confidence Intervals 0.690 ± 0.058 > 0.670 ± 0.062
Sensitivity 0.630 > 0.600
Positive Predictive Value 0.657 > 0.605
Total TP 1434 > 1367
Total TN 173568 > 173493
Total FP 929 < 1070
Total FP CONTRA 214 < 257
Total FP INCONS 536 < 635
Total FP COMP 179 > 178
Total FN 843 < 910
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Vsfold4 and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold4 and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold4 and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold4 and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold4 and Vsfold5).

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Performance of Vsfold4 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1434
Total TN 173568
Total FP 929
Total FP CONTRA 214
Total FP INCONS 536
Total FP COMP 179
Total FN 843
Total Scores
MCC 0.638
Average MCC ± 95% Confidence Intervals 0.690 ± 0.058
Sensitivity 0.630
Positive Predictive Value 0.657
Nr of predictions 126

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.35 0.36 0.40 4 176 6 0 6 0 7
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 0.78 0.63 1.00 5 97 0 0 0 0 3
2KFC_A - 0.79 0.63 1.00 5 231 0 0 0 0 3
2KGP_A - -0.05 0.00 0.00 0 117 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.84 0.83 0.86 19 2002 9 2 1 6 4
2KU0_A - -0.04 0.00 0.00 0 283 9 2 7 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.67 0.57 0.81 13 747 3 0 3 0 10
2L1F_B 0.69 0.58 0.82 14 774 3 0 3 0 10
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.94 0.89 1.00 16 341 1 0 0 1 2
2LA5_A - 0.77 0.71 0.83 5 269 1 0 1 0 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.35 0.38 0.34 11 2408 21 7 14 0 18
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - -0.07 0.00 0.00 0 68 4 0 4 0 7
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.12 0.10 0.17 1 735 8 1 4 3 9
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1808 27 13 14 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2016 29 1 28 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.75 0.67 0.86 12 892 4 0 2 2 6
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.18 0.20 0.19 3 1342 22 4 9 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.95 0.91 1.00 30 1789 0 0 0 0 3
3AKZ_H 0.77 0.75 0.79 15 1108 6 2 2 2 5
3AM1_B - 0.93 0.86 1.00 25 1441 0 0 0 0 4
3AMU_B 0.73 0.74 0.74 14 1138 8 0 5 3 5
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.41 0.46 0.38 12 2704 21 10 10 1 14
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.60 0.57 0.64 16 1424 10 0 9 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.53 0.56 0.53 9 592 8 2 6 0 7
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.28 0.25 0.35 7 1452 13 2 11 0 21
3IYQ_A 0.27 0.35 0.21 18 22353 80 40 29 11 33
3IZ4_A 0.39 0.39 0.39 37 25441 63 15 43 5 58
3IZF_C 0.85 0.83 0.88 29 2607 6 0 4 2 6
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_1 - 0.26 0.23 0.33 3 475 7 2 4 1 10
3J0L_h - 0.44 0.38 0.52 12 2117 11 2 9 0 20
3J0L_2 - 0.47 0.46 0.50 12 2226 18 1 11 6 14
3J0L_7 - 0.69 0.70 0.70 7 509 4 1 2 1 3
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3J20_0 0.95 0.95 0.95 20 1198 2 1 0 1 1
3J20_1 0.75 0.75 0.75 15 1092 7 0 5 2 5
3J2C_O - 0.33 0.32 0.36 13 3951 26 3 20 3 28
3J2L_3 0.71 0.71 0.73 24 2987 12 3 6 3 10
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_4 0.19 0.25 0.15 3 4736 33 9 8 16 9
3JYX_3 0.64 0.67 0.63 10 2362 16 5 1 10 5
3KTW_C - 0.43 0.40 0.48 10 1759 15 2 9 4 15
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.33 0.32 0.35 14 3674 26 2 24 0 30
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.57 0.33 1.00 1 215 3 0 0 3 2
3NPB_A 0.66 0.59 0.73 22 2248 10 0 8 2 15
3O58_3 0.12 0.14 0.11 3 4737 35 8 16 11 19
3O58_2 0.53 0.52 0.55 16 2725 16 3 10 3 15
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.66 0.69 0.65 11 1276 10 3 3 4 5
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.74 0.70 0.79 23 1960 7 1 5 1 10
3ZEX_D 0.66 0.63 0.71 22 2765 10 4 5 1 13
3ZEX_E - 0.12 0.15 0.11 5 8259 40 13 27 0 29
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ATO_G - 0.38 0.43 0.38 3 212 5 5 0 0 4
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1367
Total TN 173493
Total FP 1070
Total FP CONTRA 257
Total FP INCONS 635
Total FP COMP 178
Total FN 910
Total Scores
MCC 0.598
Average MCC ± 95% Confidence Intervals 0.670 ± 0.062
Sensitivity 0.600
Positive Predictive Value 0.605
Nr of predictions 126

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 0.95 0.90 1.00 9 165 0 0 0 0 1
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 0.78 0.63 1.00 5 97 0 0 0 0 3
2KFC_A - 0.77 0.88 0.70 7 226 3 2 1 0 1
2KGP_A - 0.81 0.67 1.00 6 115 1 0 0 1 3
2KMJ_A - 0.95 0.91 1.00 10 158 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.71 0.78 0.64 18 1996 13 8 2 3 5
2KU0_A - -0.04 0.00 0.00 0 281 11 0 11 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.70 0.61 0.82 14 746 3 0 3 0 9
2L1F_B 0.71 0.63 0.83 15 773 3 0 3 0 9
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.97 0.94 1.00 17 340 1 0 0 1 1
2LA5_A - -0.03 0.00 0.00 0 268 7 0 7 0 7
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 0.94 0.89 1.00 8 92 0 0 0 0 1
2LKR_A - 0.31 0.31 0.32 9 2412 19 5 14 0 20
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 0.68 0.71 0.71 5 65 2 0 2 0 2
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.08 0.10 0.09 1 730 13 3 7 3 9
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1803 32 17 15 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2014 31 2 29 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.74 0.72 0.76 13 889 7 0 4 3 5
2YIE_X - 0.43 0.57 0.33 4 532 10 2 6 2 3
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.17 0.20 0.16 3 1339 25 4 12 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.72 0.61 0.87 20 1796 3 0 3 0 13
3AKZ_H 0.97 0.95 1.00 19 1108 1 0 0 1 1
3AM1_B - 0.86 0.86 0.86 25 1437 4 3 1 0 4
3AMU_B 0.77 0.79 0.75 15 1137 8 0 5 3 4
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.12 0.15 0.11 4 2699 33 9 24 0 22
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.50 0.56 0.47 9 590 10 2 8 0 7
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.26 0.25 0.30 7 1449 16 2 14 0 21
3IYQ_A 0.30 0.37 0.24 19 22361 71 36 24 11 32
3IZ4_A 0.31 0.31 0.33 29 25448 65 14 45 6 66
3IZF_C 0.85 0.83 0.88 29 2607 5 0 4 1 6
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_1 - 0.25 0.23 0.30 3 474 8 3 4 1 10
3J0L_h - 0.20 0.19 0.24 6 2115 19 3 16 0 26
3J0L_2 - 0.42 0.42 0.44 11 2225 21 1 13 7 15
3J0L_7 - -0.02 0.00 0.00 0 506 13 3 10 0 10
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3J20_0 0.76 0.76 0.76 16 1198 6 3 2 1 5
3J20_1 0.75 0.75 0.75 15 1092 7 0 5 2 5
3J2C_O - 0.33 0.32 0.36 13 3951 26 3 20 3 28
3J2L_3 0.70 0.71 0.71 24 2986 13 3 7 3 10
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_4 0.63 0.83 0.48 10 4735 32 9 2 21 2
3JYX_3 0.12 0.13 0.11 2 2360 20 6 10 4 13
3KTW_C - 0.46 0.44 0.50 11 1758 15 2 9 4 14
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NDB_M - 0.07 0.07 0.08 3 3678 33 2 31 0 41
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.28 0.33 0.25 1 212 5 2 1 2 2
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3O58_2 0.50 0.52 0.50 16 2722 19 3 13 3 15
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.24 0.31 0.20 5 1268 20 9 11 0 11
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
3W3S_B 0.83 0.85 0.82 28 1955 7 2 4 1 5
3ZEX_D 0.09 0.09 0.12 3 2771 24 5 17 2 32
3ZEX_E - 0.11 0.15 0.09 5 8247 54 21 31 2 29
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ATO_G - 0.67 0.86 0.55 6 209 5 5 0 0 1
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.