CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Vsfold5 - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Vsfold5 & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Vsfold5 Carnac(seed)
MCC 0.580 > 0.282
Average MCC ± 95% Confidence Intervals 0.607 ± 0.130 > 0.153 ± 0.111
Sensitivity 0.576 > 0.081
Positive Predictive Value 0.595 < 1.000
Total TP 457 > 64
Total TN 54353 < 55057
Total FP 380 > 1
Total FP CONTRA 83 > 0
Total FP INCONS 228 > 0
Total FP COMP 69 > 1
Total FN 336 < 729
P-value 5.23657817852e-08

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Performance plots


  1. Comparison of performance of Vsfold5 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  2. Comparison of performance of Vsfold5 and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold5 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for Vsfold5 and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Vsfold5 and Carnac(seed)).

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Performance of Vsfold5 - scored higher in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 457
Total TN 54353
Total FP 380
Total FP CONTRA 83
Total FP INCONS 228
Total FP COMP 69
Total FN 336
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.607 ± 0.130
Sensitivity 0.576
Positive Predictive Value 0.595
Nr of predictions 33

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.90 1.00 9 165 0 0 0 0 1
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2L1F_A 0.70 0.61 0.82 14 746 3 0 3 0 9
2L1F_B 0.71 0.63 0.83 15 773 3 0 3 0 9
2L94_A 0.97 0.94 1.00 17 340 1 0 0 1 1
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2XKV_B -0.01 0.00 0.00 0 1803 32 17 15 0 11
2XXA_G -0.02 0.00 0.00 0 2014 31 2 29 0 35
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IZF_C 0.85 0.83 0.88 29 2607 5 0 4 1 6
3JYX_4 0.63 0.83 0.48 10 4735 32 9 2 21 2
3JYX_3 0.12 0.13 0.11 2 2360 20 6 10 4 13
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_2 0.50 0.52 0.50 16 2722 19 3 13 3 15
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3W3S_B 0.83 0.85 0.82 28 1955 7 2 4 1 5
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0
4FRG_B 0.60 0.58 0.64 14 1180 8 3 5 0 10
4FRN_A 0.15 0.14 0.17 4 1825 19 3 16 0 24

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 64
Total TN 55057
Total FP 1
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 1
Total FN 729
Total Scores
MCC 0.282
Average MCC ± 95% Confidence Intervals 0.153 ± 0.111
Sensitivity 0.081
Positive Predictive Value 1.000
Nr of predictions 33

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.00 0.00 0.00 0 467 0 0 0 0 18
2KUR_A 0.60 0.37 1.00 7 460 0 0 0 0 12
2KUU_A 0.62 0.39 1.00 7 440 0 0 0 0 11
2KUV_A 0.68 0.47 1.00 9 430 0 0 0 0 10
2KUW_A 0.70 0.50 1.00 9 461 0 0 0 0 9
2L1F_A 0.00 0.00 0.00 0 763 0 0 0 0 23
2L1F_B 0.00 0.00 0.00 0 791 0 0 0 0 24
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
2XKV_B 0.00 0.00 0.00 0 1835 0 0 0 0 11
2XXA_G 0.00 0.00 0.00 0 2045 0 0 0 0 35
3A3A_A 0.00 0.00 0.00 0 1500 0 0 0 0 30
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IZF_C 0.00 0.00 0.00 0 2640 0 0 0 0 35
3JYX_4 0.00 0.00 0.00 0 4756 0 0 0 0 12
3JYX_3 0.00 0.00 0.00 0 2378 0 0 0 0 15
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_2 0.00 0.00 0.00 0 2754 0 0 0 0 31
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
3W3S_B 0.00 0.00 0.00 0 1989 0 0 0 0 33
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15
4FRG_B 0.00 0.00 0.00 0 1202 0 0 0 0 24
4FRN_A 0.00 0.00 0.00 0 1848 0 0 0 0 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.