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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Afold TurboFold(seed)
MCC 0.571 > 0.470
Average MCC ± 95% Confidence Intervals 0.632 ± 0.381 > 0.502 ± 0.507
Sensitivity 0.524 > 0.413
Positive Predictive Value 0.629 > 0.542
Total TP 66 > 52
Total TN 17692 < 17701
Total FP 52 < 53
Total FP CONTRA 6 > 5
Total FP INCONS 33 < 39
Total FP COMP 13 > 9
Total FN 60 < 74
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 66
Total TN 17692
Total FP 52
Total FP CONTRA 6
Total FP INCONS 33
Total FP COMP 13
Total FN 60
Total Scores
MCC 0.571
Average MCC ± 95% Confidence Intervals 0.632 ± 0.381
Sensitivity 0.524
Positive Predictive Value 0.629
Nr of predictions 5

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.61 0.55 0.69 11 1524 6 0 5 1 9
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
4A1C_2 0.14 0.15 0.14 5 11745 43 5 26 12 28
4ENB_A 0.67 0.58 0.79 11 1261 3 1 2 0 8

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 52
Total TN 17701
Total FP 53
Total FP CONTRA 5
Total FP INCONS 39
Total FP COMP 9
Total FN 74
Total Scores
MCC 0.470
Average MCC ± 95% Confidence Intervals 0.502 ± 0.507
Sensitivity 0.413
Positive Predictive Value 0.542
Nr of predictions 5

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
4A1C_2 0.15 0.15 0.15 5 11748 37 3 25 9 28
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.