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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Alterna - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Alterna & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Alterna Multilign(seed)
MCC 0.624 > 0.588
Average MCC ± 95% Confidence Intervals 0.646 ± 0.390 > 0.556 ± 0.648
Sensitivity 0.534 > 0.483
Positive Predictive Value 0.738 > 0.727
Total TP 62 > 56
Total TN 8573 < 8580
Total FP 22 > 21
Total FP CONTRA 2 = 2
Total FP INCONS 20 > 19
Total FP COMP 0 = 0
Total FN 54 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of Alterna and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and Multilign(seed)).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 62
Total TN 8573
Total FP 22
Total FP CONTRA 2
Total FP INCONS 20
Total FP COMP 0
Total FN 54
Total Scores
MCC 0.624
Average MCC ± 95% Confidence Intervals 0.646 ± 0.390
Sensitivity 0.534
Positive Predictive Value 0.738
Nr of predictions 4

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.46 0.40 0.53 8 1525 7 0 7 0 12
3RKF_A 0.69 0.56 0.86 19 2189 3 1 2 0 15
3SD1_A 0.46 0.38 0.57 16 3888 12 1 11 0 26

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 56
Total TN 8580
Total FP 21
Total FP CONTRA 2
Total FP INCONS 19
Total FP COMP 0
Total FN 60
Total Scores
MCC 0.588
Average MCC ± 95% Confidence Intervals 0.556 ± 0.648
Sensitivity 0.483
Positive Predictive Value 0.727
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.