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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Alterna - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Alterna & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Alterna TurboFold(seed)
MCC 0.624 > 0.594
Average MCC ± 95% Confidence Intervals 0.646 ± 0.390 > 0.566 ± 0.650
Sensitivity 0.534 > 0.500
Positive Predictive Value 0.738 > 0.716
Total TP 62 > 58
Total TN 8573 < 8576
Total FP 22 < 23
Total FP CONTRA 2 < 3
Total FP INCONS 20 = 20
Total FP COMP 0 = 0
Total FN 54 < 58
P-value 0.0

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Performance plots


  1. Comparison of performance of Alterna and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and TurboFold(seed)).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 62
Total TN 8573
Total FP 22
Total FP CONTRA 2
Total FP INCONS 20
Total FP COMP 0
Total FN 54
Total Scores
MCC 0.624
Average MCC ± 95% Confidence Intervals 0.646 ± 0.390
Sensitivity 0.534
Positive Predictive Value 0.738
Nr of predictions 4

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.46 0.40 0.53 8 1525 7 0 7 0 12
3RKF_A 0.69 0.56 0.86 19 2189 3 1 2 0 15
3SD1_A 0.46 0.38 0.57 16 3888 12 1 11 0 26

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 58
Total TN 8576
Total FP 23
Total FP CONTRA 3
Total FP INCONS 20
Total FP COMP 0
Total FN 58
Total Scores
MCC 0.594
Average MCC ± 95% Confidence Intervals 0.566 ± 0.650
Sensitivity 0.500
Positive Predictive Value 0.716
Nr of predictions 4

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.59 0.48 0.74 20 3889 7 1 6 0 22

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.