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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(20) - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(20) & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric CMfinder(20) PPfold(seed)
MCC 0.546 > 0.000
Average MCC ± 95% Confidence Intervals 0.560 ± 0.222 > 0.000 ± 0.000
Sensitivity 0.366 > 0.000
Positive Predictive Value 0.822 > 0.000
Total TP 60 > 0
Total TN 21159 < 21232
Total FP 15 > 0
Total FP CONTRA 1 > 0
Total FP INCONS 12 > 0
Total FP COMP 2 > 0
Total FN 104 < 164
P-value 0.0

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Performance plots


  1. Comparison of performance of CMfinder(20) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(20) and PPfold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(20) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(20) and PPfold(seed)).

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Performance of CMfinder(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 60
Total TN 21159
Total FP 15
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 2
Total FN 104
Total Scores
MCC 0.546
Average MCC ± 95% Confidence Intervals 0.560 ± 0.222
Sensitivity 0.366
Positive Predictive Value 0.822
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.75 0.57 1.00 17 2833 1 0 0 1 13
3J2L_3 0.45 0.32 0.63 17 7848 11 1 9 1 36
3ZEX_D 0.58 0.39 0.86 19 6999 3 0 3 0 30
4FRG_B 0.47 0.22 1.00 7 3479 0 0 0 0 25

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 0
Total TN 21232
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 164
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 4

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.00 0.00 0.00 0 2850 0 0 0 0 30
3J2L_3 0.00 0.00 0.00 0 7875 0 0 0 0 53
3ZEX_D 0.00 0.00 0.00 0 7021 0 0 0 0 49
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.