CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(20) Murlet(seed)
MCC 0.514 > 0.463
Average MCC ± 95% Confidence Intervals 0.442 ± 0.123 < 0.469 ± 0.058
Sensitivity 0.283 > 0.250
Positive Predictive Value 0.939 > 0.863
Total TP 186 > 164
Total TN 107223 < 107231
Total FP 21 < 32
Total FP CONTRA 2 < 5
Total FP INCONS 10 < 21
Total FP COMP 9 > 6
Total FN 471 < 493
P-value 2.28439804626e-08

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Performance plots


  1. Comparison of performance of Carnac(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 186
Total TN 107223
Total FP 21
Total FP CONTRA 2
Total FP INCONS 10
Total FP COMP 9
Total FN 471
Total Scores
MCC 0.514
Average MCC ± 95% Confidence Intervals 0.442 ± 0.123
Sensitivity 0.283
Positive Predictive Value 0.939
Nr of predictions 19

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.73 0.55 1.00 6 400 0 0 0 0 5
2L94_A 0.00 0.00 0.00 0 990 0 0 0 0 20
2XKV_B 0.32 0.10 1.00 2 4558 1 0 0 1 18
2XXA_G 0.27 0.07 1.00 3 5148 0 0 0 0 39
3GX2_A 0.57 0.33 1.00 13 4358 0 0 0 0 27
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3JYX_4 0.46 0.21 1.00 7 12239 2 0 0 2 26
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.44 0.20 1.00 9 7012 2 0 0 2 37
3O58_3 0.51 0.26 1.00 9 12394 0 0 0 0 26
3PDR_A 0.62 0.40 0.97 29 12850 3 0 1 2 43
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
3ZEX_C 0.31 0.13 0.70 7 14186 3 1 2 0 45
4A1C_2 0.33 0.15 0.71 5 11774 3 0 2 1 28
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.43 0.19 1.00 6 3480 0 0 0 0 26

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 164
Total TN 107231
Total FP 32
Total FP CONTRA 5
Total FP INCONS 21
Total FP COMP 6
Total FN 493
Total Scores
MCC 0.463
Average MCC ± 95% Confidence Intervals 0.469 ± 0.058
Sensitivity 0.250
Positive Predictive Value 0.863
Nr of predictions 19

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.52 0.27 1.00 3 403 0 0 0 0 8
2L94_A 0.59 0.40 0.89 8 981 1 0 1 0 12
2XKV_B 0.45 0.20 1.00 4 4556 2 0 0 2 16
2XXA_G 0.38 0.14 1.00 6 5145 0 0 0 0 36
3GX2_A 0.59 0.35 1.00 14 4357 1 0 0 1 26
3IVN_B 0.53 0.39 0.75 12 2330 4 2 2 0 19
3JYX_4 0.23 0.09 0.60 3 12241 4 0 2 2 30
3LA5_A 0.58 0.41 0.82 14 2468 3 1 2 0 20
3NPB_A 0.49 0.28 0.87 13 7006 2 1 1 0 33
3O58_3 0.45 0.20 1.00 7 12396 0 0 0 0 28
3PDR_A 0.44 0.19 1.00 14 12866 0 0 0 0 58
3RKF_A 0.53 0.35 0.80 12 2196 3 1 2 0 22
3SD1_A 0.47 0.26 0.85 11 3903 2 0 2 0 31
3ZEX_C 0.37 0.13 1.00 7 14189 0 0 0 0 45
4A1C_2 0.46 0.21 1.00 7 11774 0 0 0 0 26
4AOB_A 0.58 0.33 1.00 14 4357 1 0 0 1 28
4ENB_A 0.56 0.32 1.00 6 1269 0 0 0 0 13
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13
4FRG_B 0.15 0.09 0.25 3 3474 9 0 9 0 29

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.