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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) Multilign(seed)
MCC 0.571 > 0.542
Average MCC ± 95% Confidence Intervals 0.529 ± 0.308 < 0.561 ± 0.292
Sensitivity 0.386 < 0.413
Positive Predictive Value 0.851 > 0.719
Total TP 86 < 92
Total TN 33086 > 33059
Total FP 16 < 37
Total FP CONTRA 1 < 9
Total FP INCONS 14 < 27
Total FP COMP 1 = 1
Total FN 137 > 131
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 86
Total TN 33086
Total FP 16
Total FP CONTRA 1
Total FP INCONS 14
Total FP COMP 1
Total FN 137
Total Scores
MCC 0.571
Average MCC ± 95% Confidence Intervals 0.529 ± 0.308
Sensitivity 0.386
Positive Predictive Value 0.851
Nr of predictions 6

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.61 0.55 0.69 11 974 5 0 5 0 9
3J3E_8 0.00 0.00 0.00 0 7499 4 0 4 0 33
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.71 0.52 0.96 22 3893 1 0 1 0 20
3ZEX_C 0.38 0.21 0.69 11 14180 5 1 4 0 41
4AOB_A 0.75 0.57 1.00 24 4347 1 0 0 1 18

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 92
Total TN 33059
Total FP 37
Total FP CONTRA 9
Total FP INCONS 27
Total FP COMP 1
Total FN 131
Total Scores
MCC 0.542
Average MCC ± 95% Confidence Intervals 0.561 ± 0.292
Sensitivity 0.413
Positive Predictive Value 0.719
Nr of predictions 6

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
3J3E_8 0.13 0.09 0.19 3 7487 13 5 8 0 30
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
3ZEX_C 0.39 0.27 0.58 14 14172 10 3 7 0 38
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.