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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidFold - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidFold & Vsfold4 [.zip] - may take several seconds...


Overview

Metric CentroidFold Vsfold4
MCC 0.625 > 0.524
Average MCC ± 95% Confidence Intervals 0.678 ± 0.051 > 0.598 ± 0.056
Sensitivity 0.543 > 0.445
Positive Predictive Value 0.723 > 0.624
Total TP 1851 > 1516
Total TN 516270 < 516401
Total FP 822 < 1019
Total FP CONTRA 94 > 90
Total FP INCONS 615 < 823
Total FP COMP 113 > 106
Total FN 1557 < 1892
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of CentroidFold and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidFold and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and Vsfold4).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP 1851
Total TN 516270
Total FP 822
Total FP CONTRA 94
Total FP INCONS 615
Total FP COMP 113
Total FN 1557
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.678 ± 0.051
Sensitivity 0.543
Positive Predictive Value 0.723
Nr of predictions 126

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - 0.47 0.31 0.71 5 696 2 0 2 0 11
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.89 0.80 1.00 8 343 0 0 0 0 2
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LA5_A - 0.42 0.26 0.71 5 623 2 0 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.49 0.35 0.70 7 1530 3 1 2 0 13
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.82 0.74 0.91 29 6073 4 0 3 1 10
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LU0_A - 0.93 0.88 1.00 14 1162 0 0 0 0 2
2LWK_A - 0.92 0.92 0.92 12 483 1 0 1 0 1
2M58_A - 0.09 0.06 0.14 1 1646 6 0 6 0 16
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.57 0.59 0.56 10 2832 12 5 3 4 7
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_E - 0.00 0.00 0.00 0 561 0 0 0 0 14
2WW9_D - 0.29 0.12 0.75 3 1949 1 0 1 0 23
2WWQ_V 0.80 0.68 0.95 19 2906 3 0 1 2 9
2XKV_B 0.51 0.50 0.53 10 4541 25 0 9 16 10
2XQD_Y 0.75 0.67 0.86 18 2829 3 0 3 0 9
2XXA_G 0.15 0.12 0.20 5 5126 20 1 19 0 37
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.66 0.63 0.71 15 2257 8 1 5 2 9
2YIE_Z - 0.43 0.42 0.45 5 1529 6 3 3 0 7
2YIE_X - 0.67 0.58 0.78 7 1369 3 1 1 1 5
2ZZM_B 0.18 0.16 0.23 5 3464 17 3 14 0 27
2ZZN_D 0.82 0.78 0.88 21 2461 3 0 3 0 6
3A2K_C 0.44 0.43 0.46 12 2900 14 2 12 0 16
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.43 0.39 0.48 11 2678 12 2 10 0 17
3AM1_B - 0.68 0.63 0.73 22 3210 8 1 7 0 13
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3GX2_A 0.79 0.63 1.00 25 4346 1 0 0 1 15
3IAB_R - 0.86 0.86 0.86 12 1021 4 1 1 2 2
3ID5_D - -0.01 0.00 0.00 0 490 6 3 3 0 9
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.80 0.67 0.96 22 4255 1 0 1 0 11
3IYQ_A 0.36 0.37 0.34 35 60624 71 17 50 4 59
3IZ4_A 0.55 0.45 0.68 59 70789 33 4 24 5 73
3IZF_C 0.68 0.61 0.77 33 6860 10 1 9 0 21
3J0L_g - 0.00 0.00 0.00 0 465 0 0 0 0 4
3J0L_2 - 0.25 0.24 0.28 8 6187 24 0 21 3 25
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.41 0.31 0.56 5 1119 4 2 2 0 11
3J0L_1 - 0.65 0.47 0.90 9 1215 2 0 1 1 10
3J0L_h - 0.77 0.65 0.90 28 6074 5 0 3 2 15
3J0L_7 - -0.01 0.00 0.00 0 1220 5 0 5 0 17
3J16_L 0.50 0.40 0.63 12 2756 7 0 7 0 18
3J20_1 0.91 0.87 0.95 20 2905 2 0 1 1 3
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J2C_O - 0.76 0.65 0.89 41 10250 6 0 5 1 22
3J2L_3 0.53 0.49 0.58 26 7830 21 0 19 2 27
3J3D_C 0.49 0.43 0.57 12 2754 9 0 9 0 16
3J3E_8 0.00 0.00 0.00 0 7485 21 2 16 3 33
3J3E_7 0.46 0.37 0.59 20 7106 14 1 13 0 34
3J3F_7 0.20 0.18 0.23 9 7221 30 1 29 0 41
3J3F_8 0.34 0.33 0.34 12 12211 34 4 19 11 24
3J3V_B 0.47 0.37 0.60 21 6986 14 1 13 0 36
3JYV_7 0.77 0.59 1.00 19 2831 0 0 0 0 13
3JYX_4 0.23 0.21 0.25 7 12218 25 5 16 4 26
3JYX_3 0.29 0.30 0.30 8 6301 20 8 11 1 19
3KTW_C - 0.45 0.40 0.53 17 4528 16 2 13 1 26
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.80 0.70 0.91 43 9133 5 0 4 1 18
3NKB_B - 0.57 0.50 0.65 13 1996 7 0 7 0 13
3NMU_E - 0.71 0.50 1.00 3 558 3 0 0 3 3
3NPB_A 0.77 0.70 0.86 32 6984 7 1 4 2 14
3O58_2 0.82 0.76 0.88 29 7227 7 1 3 3 9
3O58_3 0.38 0.29 0.50 10 12383 10 0 10 0 25
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 1 0 0 1 1
3PDR_A 0.73 0.60 0.90 43 12832 7 0 5 2 29
3R4F_A - 0.81 0.76 0.86 19 2123 3 1 2 0 6
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.58 0.48 0.71 20 3888 8 1 7 0 22
3SIU_F - 0.79 0.64 1.00 7 371 0 0 0 0 4
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.57 0.46 0.71 17 3136 7 0 7 0 20
3UZL_B 0.72 0.54 0.95 20 3549 1 0 1 0 17
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.87 0.78 0.97 31 4721 2 0 1 1 9
3ZEX_D 0.73 0.59 0.91 29 6989 3 0 3 0 20
3ZEX_E - 0.00 0.00 0.00 0 21895 52 3 47 2 77
3ZEX_G - 0.36 0.28 0.46 21 16425 29 2 23 4 53
3ZND_W 0.20 0.22 0.19 5 2977 23 1 20 2 18
4A1C_3 0.67 0.56 0.81 30 7103 7 1 6 0 24
4A1C_2 0.16 0.15 0.17 5 11752 29 5 19 5 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.45 0.33 0.61 14 4348 10 1 8 1 28
4ATO_G - 0.31 0.20 0.50 2 524 2 0 2 0 8
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.73 0.58 0.92 11 1314 1 1 0 0 8
4FRG_B 0.24 0.22 0.28 7 3461 18 3 15 0 25
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0
4JF2_A 0.78 0.61 1.00 19 2831 0 0 0 0 12
4JRC_A - 0.81 0.70 0.94 16 1523 1 0 1 0 7

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1516
Total TN 516401
Total FP 1019
Total FP CONTRA 90
Total FP INCONS 823
Total FP COMP 106
Total FN 1892
Total Scores
MCC 0.524
Average MCC ± 95% Confidence Intervals 0.598 ± 0.056
Sensitivity 0.445
Positive Predictive Value 0.624
Nr of predictions 126

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.65 0.53 0.81 21 5125 7 0 5 2 19
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.66 0.54 0.81 13 2064 3 0 3 0 11
2L1F_B 0.68 0.56 0.82 14 2128 3 0 3 0 11
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.31 0.28 0.34 11 6073 21 3 18 0 28
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LU0_A - 0.69 0.63 0.77 10 1163 3 0 3 0 6
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2M58_A - -0.01 0.00 0.00 0 1647 6 0 6 0 17
2RPT_A - -0.03 0.00 0.00 0 186 4 0 4 0 7
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.19 0.12 0.33 3 1944 6 0 6 0 23
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4533 27 8 19 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5122 29 1 28 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.63 0.50 0.80 12 2263 4 0 3 1 12
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2ZZM_B 0.21 0.19 0.24 6 3461 19 0 19 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.89 0.79 1.00 30 4156 0 0 0 0 8
3AKZ_H 0.67 0.57 0.80 16 2681 5 1 3 1 12
3AM1_B - 0.84 0.71 1.00 25 3215 0 0 0 0 10
3AMU_B 0.64 0.56 0.75 15 2983 7 0 5 2 12
3GX2_A 0.50 0.40 0.64 16 4346 10 0 9 1 24
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.27 0.21 0.35 7 4258 13 1 12 0 26
3IYQ_A 0.29 0.29 0.29 27 60634 71 13 52 6 67
3IZ4_A 0.36 0.31 0.43 41 70780 59 7 48 4 91
3IZF_C 0.69 0.56 0.86 30 6868 5 0 5 0 24
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_2 - 0.38 0.36 0.41 12 6187 18 3 14 1 21
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_1 - 0.28 0.21 0.40 4 1215 6 1 5 0 15
3J0L_h - 0.38 0.28 0.52 12 6082 11 0 11 0 31
3J0L_7 - 0.51 0.41 0.64 7 1214 4 0 4 0 10
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.57 0.45 0.73 24 7842 12 1 8 3 29
3J3D_C 0.44 0.39 0.50 11 2753 11 1 10 0 17
3J3E_8 0.07 0.06 0.09 2 7481 32 2 18 12 31
3J3E_7 0.48 0.35 0.66 19 7111 10 0 10 0 35
3J3F_7 0.21 0.18 0.26 9 7226 25 0 25 0 41
3J3F_8 0.33 0.31 0.37 11 12216 27 4 15 8 25
3J3V_B 0.17 0.12 0.24 7 6992 22 1 21 0 50
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_4 0.10 0.09 0.12 3 12220 33 2 21 10 30
3JYX_3 0.60 0.56 0.65 15 6305 11 4 4 3 12
3KTW_C - 0.36 0.28 0.48 12 4535 13 3 10 0 31
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.28 0.23 0.35 14 9140 26 0 26 0 47
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.61 0.50 0.74 23 6990 9 0 8 1 23
3O58_2 0.47 0.42 0.53 16 7230 16 3 11 2 22
3O58_3 0.09 0.09 0.10 3 12373 35 5 22 8 32
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.19 0.17 0.24 7 3887 22 1 21 0 35
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.53 0.41 0.71 15 3549 6 1 5 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.67 0.58 0.79 23 4724 7 0 6 1 17
3ZEX_D 0.55 0.45 0.69 22 6989 10 0 10 0 27
3ZEX_E - 0.08 0.06 0.11 5 21900 40 1 39 0 72
3ZEX_G - 0.30 0.23 0.39 17 16427 27 2 25 0 57
3ZND_W 0.41 0.39 0.43 9 2982 14 2 10 2 14
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.28 0.24 0.33 8 11757 28 0 16 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.69 0.47 1.00 9 1317 0 0 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0
4JF2_A 0.66 0.52 0.84 16 2831 3 0 3 0 15
4JRC_A - 0.29 0.22 0.42 5 1528 7 0 7 0 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.