CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidHomfold‑LAST		MCFold
MCC	0.622	>	0.480
Average MCC ± 95% Confidence Intervals	0.657 ± 0.079	>	0.541 ± 0.093
Sensitivity	0.510	>	0.490
Positive Predictive Value	0.765	>	0.479
Total TP	695	>	669
Total TN	164431	>	163944
Total FP	257	<	861
Total FP CONTRA	21	<	79
Total FP INCONS	193	<	648
Total FP COMP	43	<	134
Total FN	669	<	695
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidHomfold-LAST and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and MCFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidHomfold‑LAST and MCFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and MCFold).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP	695
Total TN	164431
Total FP	257
Total FP CONTRA	21
Total FP INCONS	193
Total FP COMP	43
Total FN	669

Total Scores
MCC	0.622
Average MCC ± 95% Confidence Intervals	0.657 ± 0.079
Sensitivity	0.510
Positive Predictive Value	0.765
Nr of predictions	59

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2L94_A	HIV_FE links to Rfam database...	0.92	0.90	0.95	18	971	1	0	1	0	2
2LA5_A	-	0.46	0.26	0.83	5	624	1	0	1	0	14
2LBS_A	-	1.00	1.00	1.00	14	482	0	0	0	0	0
2LC8_A	GP_knot1 links to Rfam database...	-0.01	0.00	0.00	0	1529	11	0	11	0	20
2LDL_A	-	0.90	0.82	1.00	9	342	1	0	0	1	2
2LDT_A	-	0.72	0.53	1.00	8	457	0	0	0	0	7
2LHP_A	-	0.97	0.94	1.00	15	651	0	0	0	0	1
2LJJ_A	-	1.00	1.00	1.00	8	343	2	0	0	2	0
2LK3_A	-	0.95	0.90	1.00	9	267	0	0	0	0	1
2LKR_A	-	0.00	0.00	0.00	0	6101	4	0	4	0	39
2LQZ_A	-	0.85	0.82	0.90	9	341	1	1	0	0	2
2LU0_A	-	0.93	0.88	1.00	14	1162	0	0	0	0	2
2LWK_A	-	0.83	0.77	0.91	10	485	1	0	1	0	3
2M58_A	-	-0.01	0.00	0.00	0	1648	5	0	5	0	17
2RRC_A	-	0.70	0.50	1.00	5	226	0	0	0	0	5
2Y8W_B	-	1.00	1.00	1.00	6	184	1	0	0	1	0
2Y9C_V	-	0.20	0.04	1.00	1	2277	0	0	0	0	23
2YIE_Z	-	0.82	0.67	1.00	8	1532	0	0	0	0	4
2YIE_X	-	0.76	0.58	1.00	7	1371	0	0	0	0	5
3AMU_B	tRNA links to Rfam database...	0.82	0.70	0.95	19	2983	3	0	1	2	8
3J0L_g	-	0.00	0.00	0.00	0	465	0	0	0	0	4
3J0L_8	-	0.93	0.88	1.00	7	183	0	0	0	0	1
3J0L_a	-	-0.01	0.00	0.00	0	1125	3	0	3	0	16
3J0L_1	-	0.65	0.47	0.90	9	1215	2	0	1	1	10
3J0L_h	-	0.76	0.63	0.93	27	6076	4	0	2	2	16
3J0L_7	-	0.60	0.41	0.88	7	1217	1	0	1	0	10
3J0L_2	-	0.49	0.24	1.00	8	6208	0	0	0	0	25
3J16_L	tRNA links to Rfam database...	0.75	0.57	1.00	17	2758	0	0	0	0	13
3J20_0	tRNA links to Rfam database...	0.35	0.37	0.34	11	2818	22	3	18	1	19
3J2L_3	5S_rRNA links to Rfam database...	0.73	0.62	0.87	33	7837	7	0	5	2	20
3J3D_C	tRNA links to Rfam database...	0.68	0.61	0.77	17	2753	5	0	5	0	11
3J3E_8	5_8S_rRNA links to Rfam database...	0.05	0.03	0.08	1	7490	16	1	11	4	32
3J3E_7	5S_rRNA links to Rfam database...	0.64	0.54	0.76	29	7102	9	0	9	0	25
3J3F_7	5S_rRNA links to Rfam database...	0.65	0.58	0.74	29	7221	10	1	9	0	21
3J3F_8	5_8S_rRNA links to Rfam database...	0.33	0.33	0.33	12	12210	33	4	20	9	24
3NMU_E	-	0.41	0.17	1.00	1	560	3	0	0	3	5
3R9X_C	-	0.84	0.80	0.89	8	586	2	0	1	1	2
3RKF_A	Purine links to Rfam database...	0.72	0.53	1.00	18	2193	0	0	0	0	16
3SD1_A	THF links to Rfam database...	0.64	0.45	0.90	19	3895	2	0	2	0	23
3SIU_F	-	0.73	0.55	1.00	6	372	0	0	0	0	5
3SN2_B	IRE_II links to Rfam database...	0.91	0.83	1.00	10	396	0	0	0	0	2
3TRZ_Z	-	0.91	0.83	1.00	5	205	1	0	0	1	1
3TS0_U	-	1.00	1.00	1.00	6	247	1	0	0	1	0
3TS2_V	-	1.00	1.00	1.00	5	271	0	0	0	0	0
3U4M_B	-	0.58	0.43	0.80	16	3140	4	0	4	0	21
3VJR_D	-	0.96	0.92	1.00	12	618	0	0	0	0	1
3ZEX_D	5S_rRNA links to Rfam database...	0.75	0.65	0.86	32	6984	5	0	5	0	17
3ZEX_G	-	0.75	0.61	0.92	45	16422	7	0	4	3	29
3ZND_W	tRNA links to Rfam database...	0.47	0.39	0.56	9	2987	10	0	7	3	14
4A1C_2	5_8S_rRNA links to Rfam database...	0.16	0.15	0.18	5	11753	29	5	18	6	28
4A1C_3	5S_rRNA links to Rfam database...	0.68	0.56	0.83	30	7104	6	0	6	0	24
4A4U_A	-	1.00	1.00	1.00	9	222	0	0	0	0	0
4ENB_A	crcB links to Rfam database...	0.76	0.58	1.00	11	1264	0	0	0	0	8
4ENC_A	crcB links to Rfam database...	0.76	0.58	1.00	11	1315	0	0	0	0	8
4FRG_B	AdoCbl-variant links to Rfam database...	0.41	0.41	0.43	13	3456	17	3	14	0	19
4FRN_A	AdoCbl-variant links to Rfam database...	0.36	0.39	0.34	14	5110	27	3	24	0	22
4HXH_A	-	1.00	1.00	1.00	6	319	0	0	0	0	0
4JF2_A	preQ1-II links to Rfam database...	0.78	0.61	1.00	19	2831	0	0	0	0	12
4JRC_A	-	0.75	0.57	1.00	13	1527	0	0	0	0	10

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP	669
Total TN	163944
Total FP	861
Total FP CONTRA	79
Total FP INCONS	648
Total FP COMP	134
Total FN	695

Total Scores
MCC	0.480
Average MCC ± 95% Confidence Intervals	0.541 ± 0.093
Sensitivity	0.490
Positive Predictive Value	0.479
Nr of predictions	59

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2L94_A	HIV_FE links to Rfam database...	0.97	0.95	1.00	19	971	0	0	0	0	1
2LA5_A	-	-0.03	0.00	0.00	0	615	15	0	15	0	19
2LBS_A	-	1.00	1.00	1.00	14	482	1	0	0	1	0
2LC8_A	GP_knot1 links to Rfam database...	0.41	0.45	0.39	9	1517	16	0	14	2	11
2LDL_A	-	0.95	0.91	1.00	10	341	2	0	0	2	1
2LDT_A	-	0.75	0.73	0.79	11	451	3	0	3	0	4
2LHP_A	-	1.00	1.00	1.00	16	650	1	0	0	1	0
2LJJ_A	-	1.00	1.00	1.00	8	343	2	0	0	2	0
2LK3_A	-	1.00	1.00	1.00	10	266	0	0	0	0	0
2LKR_A	-	0.93	0.92	0.95	36	6067	14	0	2	12	3
2LQZ_A	-	0.91	0.91	0.91	10	340	1	1	0	0	1
2LU0_A	-	1.00	1.00	1.00	16	1160	5	0	0	5	0
2LWK_A	-	0.92	0.92	0.92	12	483	2	0	1	1	1
2M58_A	-	0.20	0.24	0.18	4	1631	19	2	16	1	13
2RRC_A	-	0.95	0.90	1.00	9	222	0	0	0	0	1
2Y8W_B	-	1.00	1.00	1.00	6	184	2	0	0	2	0
2Y9C_V	-	0.62	0.67	0.59	16	2251	13	2	9	2	8
2YIE_Z	-	0.36	0.50	0.27	6	1518	18	4	12	2	6
2YIE_X	-	0.06	0.08	0.06	1	1361	21	1	15	5	11
3AMU_B	tRNA links to Rfam database...	0.44	0.48	0.42	13	2972	18	2	16	0	14
3J0L_g	-	0.13	0.25	0.08	1	452	12	8	4	0	3
3J0L_8	-	1.00	1.00	1.00	8	182	0	0	0	0	0
3J0L_a	-	0.16	0.19	0.17	3	1110	15	1	14	0	13
3J0L_1	-	0.79	0.79	0.79	15	1206	6	0	4	2	4
3J0L_h	-	0.91	0.91	0.91	39	6062	13	0	4	9	4
3J0L_7	-	-0.01	0.00	0.00	0	1206	19	4	15	0	17
3J0L_2	-	0.21	0.24	0.18	8	6172	39	7	29	3	25
3J16_L	tRNA links to Rfam database...	0.45	0.47	0.44	14	2743	19	1	17	1	16
3J20_0	tRNA links to Rfam database...	0.59	0.57	0.63	17	2823	12	1	9	2	13
3J2L_3	5S_rRNA links to Rfam database...	0.58	0.57	0.60	30	7825	23	2	18	3	23
3J3D_C	tRNA links to Rfam database...	0.42	0.43	0.43	12	2747	18	2	14	2	16
3J3E_8	5_8S_rRNA links to Rfam database...	0.12	0.12	0.12	4	7470	46	3	26	17	29
3J3E_7	5S_rRNA links to Rfam database...	0.40	0.39	0.42	21	7090	29	3	26	0	33
3J3F_7	5S_rRNA links to Rfam database...	0.74	0.74	0.74	37	7210	17	2	11	4	13
3J3F_8	5_8S_rRNA links to Rfam database...	0.13	0.17	0.11	6	12191	61	9	40	12	30
3NMU_E	-	0.28	0.33	0.25	2	553	12	0	6	6	4
3R9X_C	-	0.69	0.70	0.70	7	585	7	0	3	4	3
3RKF_A	Purine links to Rfam database...	0.70	0.65	0.76	22	2182	7	1	6	0	12
3SD1_A	THF links to Rfam database...	0.33	0.33	0.35	14	3876	26	0	26	0	28
3SIU_F	-	0.42	0.45	0.42	5	366	7	1	6	0	6
3SN2_B	IRE_II links to Rfam database...	0.55	0.58	0.54	7	393	6	0	6	0	5
3TRZ_Z	-	-0.04	0.00	0.00	0	201	9	0	9	0	6
3TS0_U	-	1.00	1.00	1.00	6	247	2	0	0	2	0
3TS2_V	-	-0.02	0.00	0.00	0	268	9	0	8	1	5
3U4M_B	-	0.59	0.59	0.59	22	3123	15	0	15	0	15
3VJR_D	-	1.00	1.00	1.00	13	617	1	0	0	1	0
3ZEX_D	5S_rRNA links to Rfam database...	0.17	0.18	0.18	9	6970	42	4	38	0	40
3ZEX_G	-	0.00	0.00	0.00	0	16456	15	1	14	0	74
3ZND_W	tRNA links to Rfam database...	0.19	0.22	0.18	5	2975	26	1	22	3	18
4A1C_2	5_8S_rRNA links to Rfam database...	0.13	0.15	0.11	5	11735	56	10	31	15	28
4A1C_3	5S_rRNA links to Rfam database...	0.68	0.67	0.71	36	7089	17	1	14	2	18
4A4U_A	-	1.00	1.00	1.00	9	222	0	0	0	0	0
4ENB_A	crcB links to Rfam database...	0.61	0.63	0.60	12	1255	8	2	6	0	7
4ENC_A	crcB links to Rfam database...	0.28	0.32	0.27	6	1304	17	2	14	1	13
4FRG_B	AdoCbl-variant links to Rfam database...	0.32	0.34	0.31	11	3450	25	0	25	0	21
4FRN_A	AdoCbl-variant links to Rfam database...	0.12	0.14	0.12	5	5110	38	1	35	2	31
4HXH_A	-	1.00	1.00	1.00	6	319	4	0	0	4	0
4JF2_A	preQ1-II links to Rfam database...	0.66	0.68	0.66	21	2818	11	0	11	0	10
4JRC_A	-	0.20	0.22	0.21	5	1516	19	0	19	0	18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

2. Individual counts for MCFold [ download as .csv ]