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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST RNASampler(seed)
MCC 0.574 > 0.509
Average MCC ± 95% Confidence Intervals 0.548 ± 0.401 > 0.486 ± 0.303
Sensitivity 0.471 > 0.354
Positive Predictive Value 0.706 < 0.736
Total TP 89 > 67
Total TN 25065 < 25100
Total FP 44 > 33
Total FP CONTRA 5 > 0
Total FP INCONS 32 > 24
Total FP COMP 7 < 9
Total FN 100 < 122
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RNASampler(seed)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 89
Total TN 25065
Total FP 44
Total FP CONTRA 5
Total FP INCONS 32
Total FP COMP 7
Total FN 100
Total Scores
MCC 0.574
Average MCC ± 95% Confidence Intervals 0.548 ± 0.401
Sensitivity 0.471
Positive Predictive Value 0.706
Nr of predictions 6

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LC8_A -0.01 0.00 0.00 0 1529 11 0 11 0 20
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.64 0.45 0.90 19 3895 2 0 2 0 23
3W3S_B 0.85 0.73 1.00 29 4724 1 0 0 1 11
4A1C_2 0.16 0.15 0.18 5 11753 29 5 18 6 28

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 67
Total TN 25100
Total FP 33
Total FP CONTRA 0
Total FP INCONS 24
Total FP COMP 9
Total FN 122
Total Scores
MCC 0.509
Average MCC ± 95% Confidence Intervals 0.486 ± 0.303
Sensitivity 0.354
Positive Predictive Value 0.736
Nr of predictions 6

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.71 0.55 0.92 11 978 1 0 1 0 9
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
3W3S_B 0.55 0.30 1.00 12 4741 1 0 0 1 28
4A1C_2 0.31 0.24 0.40 8 11761 20 0 12 8 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.