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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold TurboFold(seed)
MCC 0.508 > 0.478
Average MCC ± 95% Confidence Intervals 0.517 ± 0.162 > 0.475 ± 0.229
Sensitivity 0.396 > 0.382
Positive Predictive Value 0.657 > 0.603
Total TP 109 > 105
Total TN 46614 > 46606
Total FP 77 < 82
Total FP CONTRA 6 < 10
Total FP INCONS 51 < 59
Total FP COMP 20 > 13
Total FN 166 < 170
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and TurboFold(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 109
Total TN 46614
Total FP 77
Total FP CONTRA 6
Total FP INCONS 51
Total FP COMP 20
Total FN 166
Total Scores
MCC 0.508
Average MCC ± 95% Confidence Intervals 0.517 ± 0.162
Sensitivity 0.396
Positive Predictive Value 0.657
Nr of predictions 8

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.55 0.50 0.63 10 1524 6 0 6 0 10
3ZEX_C 0.33 0.25 0.45 13 14167 22 1 15 6 39
4A1C_3 0.78 0.63 0.97 34 7105 1 0 1 0 20
4A1C_2 0.20 0.15 0.28 5 11763 26 0 13 13 28
4AOB_A 0.52 0.40 0.68 17 4346 9 1 7 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10
4FRN_A 0.40 0.33 0.50 12 5127 12 3 9 0 24

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 105
Total TN 46606
Total FP 82
Total FP CONTRA 10
Total FP INCONS 59
Total FP COMP 13
Total FN 170
Total Scores
MCC 0.478
Average MCC ± 95% Confidence Intervals 0.475 ± 0.229
Sensitivity 0.382
Positive Predictive Value 0.603
Nr of predictions 8

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3ZEX_C 0.39 0.27 0.56 14 14171 14 2 9 3 38
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A1C_2 0.15 0.15 0.15 5 11748 37 3 25 9 28
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10
4FRN_A 0.69 0.56 0.87 20 5128 3 1 2 0 16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.