CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Pknots - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Pknots [.zip] - may take several seconds...


Overview

Metric Contrafold Pknots
MCC 0.657 > 0.601
Average MCC ± 95% Confidence Intervals 0.703 ± 0.048 > 0.657 ± 0.054
Sensitivity 0.585 > 0.545
Positive Predictive Value 0.743 > 0.670
Total TP 1785 > 1663
Total TN 345934 > 345853
Total FP 736 < 920
Total FP CONTRA 86 < 104
Total FP INCONS 530 < 715
Total FP COMP 120 > 101
Total FN 1268 < 1390
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and Pknots. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Pknots).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Pknots).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Pknots. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Pknots).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1785
Total TN 345934
Total FP 736
Total FP CONTRA 86
Total FP INCONS 530
Total FP COMP 120
Total FN 1268
Total Scores
MCC 0.657
Average MCC ± 95% Confidence Intervals 0.703 ± 0.048
Sensitivity 0.585
Positive Predictive Value 0.743
Nr of predictions 130

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.90 0.90 0.90 9 396 2 0 1 1 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - 0.45 0.25 0.83 5 624 1 0 1 0 15
2KGP_A - 1.00 1.00 1.00 9 291 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 1.00 1.00 1.00 13 548 0 0 0 0 0
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - 0.55 0.44 0.70 7 693 3 0 3 0 9
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.89 0.80 1.00 8 343 0 0 0 0 2
2KZL_A - 0.75 0.74 0.78 14 1467 4 2 2 0 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.45 0.35 0.58 7 1528 5 2 3 0 13
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.84 0.79 0.89 31 6070 6 0 4 2 8
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.83 0.70 1.00 7 224 0 0 0 0 3
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_E - 0.00 0.00 0.00 0 561 0 0 0 0 14
2WW9_D - 0.39 0.23 0.67 6 1944 3 2 1 0 20
2WWQ_V 0.78 0.68 0.90 19 2905 4 0 2 2 9
2XKV_B 0.51 0.50 0.53 10 4541 25 0 9 16 10
2XQD_Y 0.78 0.70 0.86 19 2828 3 0 3 0 8
2XXA_G 0.13 0.12 0.15 5 5117 29 1 28 0 37
2Y8W_B - 1.00 1.00 1.00 6 184 3 0 0 3 0
2Y9C_V - 0.66 0.63 0.71 15 2257 8 1 5 2 9
2YIE_Z - 0.43 0.42 0.45 5 1529 6 3 3 0 7
2YIE_X - 0.73 0.67 0.80 8 1368 3 1 1 1 4
2ZY6_A - 0.58 0.58 0.58 7 691 5 0 5 0 5
2ZZM_B 0.53 0.47 0.60 15 3461 10 2 8 0 17
2ZZN_D 0.82 0.78 0.88 21 2461 3 0 3 0 6
3A2K_C 0.44 0.43 0.46 12 2900 14 2 12 0 16
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.39 0.39 0.41 11 2674 17 4 12 1 17
3AM1_B - 0.68 0.63 0.73 22 3210 8 1 7 0 13
3AMU_B 0.65 0.59 0.73 16 2981 8 0 6 2 11
3DW4_A - -0.02 0.00 0.00 0 345 6 0 6 0 10
3G4S_9 0.30 0.25 0.38 14 7344 23 1 22 0 43
3GCA_A - 0.49 0.29 0.83 5 522 1 0 1 0 12
3GX2_A 0.77 0.63 0.96 25 4345 2 0 1 1 15
3HAY_E - 0.91 0.83 1.00 15 2263 6 0 0 6 3
3HJW_D - 0.94 0.89 1.00 16 1637 2 0 0 2 2
3IAB_R - 0.86 0.86 0.86 12 1021 4 1 1 2 2
3ID5_D - 0.49 0.33 0.75 3 492 6 0 1 5 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.80 0.67 0.96 22 4255 1 0 1 0 11
3IZF_C 0.68 0.61 0.77 33 6860 10 1 9 0 21
3J0L_h - 0.75 0.65 0.88 28 6073 6 0 4 2 15
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.50 0.44 0.58 7 1116 5 2 3 0 9
3J0L_2 - 0.25 0.24 0.28 8 6187 26 0 21 5 25
3J0L_g - 0.00 0.00 0.00 0 464 1 1 0 0 4
3J0L_1 - 0.73 0.58 0.92 11 1213 2 0 1 1 8
3J0L_7 - -0.01 0.00 0.00 0 1218 7 0 7 0 17
3J16_L 0.46 0.40 0.55 12 2753 10 1 9 0 18
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J20_1 0.96 0.91 1.00 21 2905 4 0 0 4 2
3J2L_3 0.56 0.49 0.65 26 7835 16 0 14 2 27
3JYV_7 -0.01 0.00 0.00 0 2830 20 0 20 0 32
3JYX_4 0.20 0.21 0.20 7 12211 35 6 22 7 26
3JYX_3 0.28 0.30 0.27 8 6298 23 8 14 1 19
3KTW_C - 0.44 0.40 0.50 17 4526 18 2 15 1 26
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.81 0.72 0.92 44 9132 5 0 4 1 17
3NKB_B - 0.54 0.50 0.59 13 1994 9 0 9 0 13
3NMU_E - 0.71 0.50 1.00 3 558 3 0 0 3 3
3NPB_A 0.76 0.70 0.84 32 6983 8 1 5 2 14
3O58_3 0.28 0.26 0.31 9 12374 20 3 17 0 26
3O58_2 0.78 0.76 0.81 29 7224 10 2 5 3 9
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 1 0 0 1 1
3PDR_A 0.69 0.60 0.80 43 12826 13 0 11 2 29
3R4F_A - 0.79 0.76 0.83 19 2122 4 1 3 0 6
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.73 0.59 0.91 20 2189 2 1 1 0 14
3SD1_A 0.57 0.48 0.69 20 3887 9 2 7 0 22
3SIU_F - 0.74 0.64 0.88 7 370 1 0 1 0 4
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.59 0.46 0.77 17 3138 5 0 5 0 20
3UZL_B 0.70 0.54 0.91 20 3548 2 0 2 0 17
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.89 0.80 1.00 32 4721 1 0 0 1 8
3ZEX_H - 0.17 0.18 0.17 7 9003 35 6 29 0 31
3ZEX_D 0.73 0.67 0.80 33 6980 8 1 7 0 16
3ZEX_G - 0.28 0.24 0.33 18 16416 41 2 35 4 56
3ZEX_F - 0.00 0.00 0.00 0 2619 9 2 7 0 12
3ZEX_C 0.28 0.21 0.38 11 14167 22 3 15 4 41
4A1C_3 0.66 0.57 0.78 31 7100 9 1 8 0 23
4A1C_2 0.16 0.15 0.17 5 11751 33 5 20 8 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.44 0.36 0.56 15 4344 13 1 11 1 27
4ATO_G - 0.44 0.40 0.50 4 520 4 0 4 0 6
4ENB_A 0.73 0.58 0.92 11 1263 1 1 0 0 8
4ENC_A 0.73 0.58 0.92 11 1314 1 1 0 0 8
4FNJ_A - 0.79 0.63 1.00 10 585 0 0 0 0 6
4FRG_B 0.68 0.56 0.82 18 3464 4 1 3 0 14
4FRN_A 0.65 0.56 0.77 20 5125 6 1 5 0 16
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of Pknots - scored lower in this pairwise comparison

1. Total counts & total scores for Pknots

Total Base Pair Counts
Total TP 1663
Total TN 345853
Total FP 920
Total FP CONTRA 104
Total FP INCONS 715
Total FP COMP 101
Total FN 1390
Total Scores
MCC 0.601
Average MCC ± 95% Confidence Intervals 0.657 ± 0.054
Sensitivity 0.545
Positive Predictive Value 0.670
Nr of predictions 130

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2. Individual counts for Pknots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.90 0.82 1.00 9 397 0 0 0 0 2
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - 0.11 0.10 0.17 2 618 10 0 10 0 18
2KGP_A - 0.81 0.67 1.00 6 294 1 0 0 1 3
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.67 0.58 0.79 23 5122 9 2 4 3 17
2KU0_A - -0.02 0.00 0.00 0 693 10 0 10 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - -0.02 0.00 0.00 0 346 5 0 5 0 10
2KZL_A - 0.59 0.53 0.67 10 1470 5 1 4 0 9
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.87 0.76 1.00 13 548 0 0 0 0 4
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.79 0.75 0.83 15 1522 3 1 2 0 5
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.44 0.44 0.45 17 6067 22 4 17 1 22
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.33 0.23 0.50 3 490 3 0 3 0 10
2RP0_A - 0.66 0.58 0.78 7 342 2 1 1 0 5
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.77 0.60 1.00 6 225 0 0 0 0 4
2WRQ_Y 0.57 0.59 0.56 10 2832 12 5 3 4 7
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_E - 0.39 0.29 0.57 4 554 3 0 3 0 10
2WW9_D - 0.35 0.31 0.42 8 1934 11 2 9 0 18
2WWQ_V 0.24 0.21 0.29 6 2905 16 1 14 1 22
2XKV_B 0.23 0.25 0.22 5 4537 31 1 17 13 15
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.32 0.31 0.34 13 5113 25 1 24 0 29
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.59 0.50 0.71 12 2261 6 1 4 1 12
2YIE_Z - -0.01 0.00 0.00 0 1525 15 3 12 0 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.20 0.19 0.23 6 3460 20 2 18 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.45 0.43 0.48 12 2901 13 2 11 0 16
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.84 0.75 0.95 21 2679 1 1 0 0 7
3AM1_B - 0.91 0.83 1.00 29 3211 0 0 0 0 6
3AMU_B 0.86 0.74 1.00 20 2983 2 0 0 2 7
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.25 0.21 0.31 12 7342 27 0 27 0 45
3GCA_A - 0.35 0.24 0.57 4 521 3 0 3 0 13
3GX2_A 0.47 0.40 0.55 16 4342 14 1 12 1 24
3HAY_E - 0.86 0.83 0.88 15 2261 5 0 2 3 3
3HJW_D - 0.94 0.89 1.00 16 1637 3 0 0 3 2
3IAB_R - 0.86 0.86 0.86 12 1021 4 1 1 2 2
3ID5_D - -0.01 0.00 0.00 0 491 5 1 4 0 9
3IVN_B 0.78 0.65 0.95 20 2325 1 0 1 0 11
3IWN_A 0.21 0.18 0.25 6 4254 18 1 17 0 27
3IZF_C 0.70 0.61 0.80 33 6862 8 1 7 0 21
3J0L_h - 0.58 0.49 0.70 21 6075 11 0 9 2 22
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.35 0.31 0.42 5 1116 7 1 6 0 11
3J0L_2 - 0.36 0.36 0.36 12 6183 23 3 18 2 21
3J0L_g - -0.01 0.00 0.00 0 460 5 2 3 0 4
3J0L_1 - 0.65 0.47 0.90 9 1215 2 0 1 1 10
3J0L_7 - 0.28 0.29 0.29 5 1208 12 0 12 0 12
3J16_L 0.34 0.30 0.41 9 2753 13 0 13 0 21
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J20_1 0.96 0.91 1.00 21 2905 0 0 0 0 2
3J2L_3 0.62 0.51 0.75 27 7839 12 0 9 3 26
3JYV_7 0.81 0.66 1.00 21 2829 0 0 0 0 11
3JYX_4 0.18 0.21 0.16 7 12203 41 13 23 5 26
3JYX_3 0.34 0.37 0.31 10 6296 24 9 13 2 17
3KTW_C - 0.49 0.44 0.56 19 4526 16 2 13 1 24
3LA5_A 0.80 0.65 1.00 22 2463 0 0 0 0 12
3NDB_M - 0.77 0.69 0.88 42 9132 7 1 5 1 19
3NKB_B - 0.55 0.50 0.62 13 1995 8 0 8 0 13
3NMU_E - 0.54 0.50 0.60 3 556 5 0 2 3 3
3NPB_A 0.76 0.67 0.86 31 6985 8 1 4 3 15
3O58_3 0.27 0.31 0.24 11 12357 38 11 24 3 24
3O58_2 0.83 0.74 0.93 28 7230 3 0 2 1 10
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.54 0.44 0.65 32 12831 19 0 17 2 40
3R4F_A - 0.92 0.88 0.96 22 2122 1 0 1 0 3
3R9X_C - 0.73 0.70 0.78 7 586 5 0 2 3 3
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.65 0.52 0.81 22 3889 5 0 5 0 20
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.26 0.22 0.32 8 3135 17 0 17 0 29
3UZL_B 0.75 0.59 0.96 22 3547 1 0 1 0 15
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.71 0.63 0.81 25 4722 7 0 6 1 15
3ZEX_H - 0.20 0.21 0.20 8 9005 32 5 27 0 30
3ZEX_D 0.27 0.24 0.30 12 6981 28 0 28 0 37
3ZEX_G - 0.36 0.32 0.41 24 16413 37 3 31 3 50
3ZEX_F - 0.00 0.00 0.00 0 2619 12 2 7 3 12
3ZEX_C 0.07 0.08 0.07 4 14141 54 4 47 3 48
4A1C_3 0.25 0.22 0.29 12 7099 29 1 28 0 42
4A1C_2 0.24 0.24 0.25 8 11749 36 3 21 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.17 0.14 0.21 6 4343 23 1 21 1 36
4ATO_G - 0.30 0.30 0.33 3 519 6 2 4 0 7
4ENB_A 0.83 0.79 0.88 15 1258 2 1 1 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FNJ_A - -0.02 0.00 0.00 0 585 10 0 10 0 16
4FRG_B 0.48 0.38 0.63 12 3467 7 0 7 0 20
4FRN_A 0.51 0.42 0.63 15 5127 9 1 8 0 21
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.