CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Vsfold4 [.zip] - may take several seconds...


Overview

Metric Contrafold Vsfold4
MCC 0.642 > 0.547
Average MCC ± 95% Confidence Intervals 0.706 ± 0.048 > 0.621 ± 0.054
Sensitivity 0.574 > 0.465
Positive Predictive Value 0.722 > 0.650
Total TP 1874 > 1518
Total TN 477967 < 478227
Total FP 850 < 905
Total FP CONTRA 103 > 82
Total FP INCONS 619 < 736
Total FP COMP 128 > 87
Total FN 1391 < 1747
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Vsfold4).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1874
Total TN 477967
Total FP 850
Total FP CONTRA 103
Total FP INCONS 619
Total FP COMP 128
Total FN 1391
Total Scores
MCC 0.642
Average MCC ± 95% Confidence Intervals 0.706 ± 0.048
Sensitivity 0.574
Positive Predictive Value 0.722
Nr of predictions 129

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.90 0.90 0.90 9 396 2 0 1 1 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - 0.45 0.25 0.83 5 624 1 0 1 0 15
2KGP_A - 1.00 1.00 1.00 9 291 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 1.00 1.00 1.00 13 548 0 0 0 0 0
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - 0.55 0.44 0.70 7 693 3 0 3 0 9
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.89 0.80 1.00 8 343 0 0 0 0 2
2KZL_A - 0.75 0.74 0.78 14 1467 4 2 2 0 5
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.45 0.35 0.58 7 1528 5 2 3 0 13
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.84 0.79 0.89 31 6070 6 0 4 2 8
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.83 0.70 1.00 7 224 0 0 0 0 3
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.39 0.23 0.67 6 1944 3 2 1 0 20
2WW9_E - 0.00 0.00 0.00 0 561 0 0 0 0 14
2WWQ_V 0.78 0.68 0.90 19 2905 4 0 2 2 9
2XKV_B 0.51 0.50 0.53 10 4541 25 0 9 16 10
2XQD_Y 0.78 0.70 0.86 19 2828 3 0 3 0 8
2XXA_G 0.13 0.12 0.15 5 5117 29 1 28 0 37
2Y8W_B - 1.00 1.00 1.00 6 184 3 0 0 3 0
2Y9C_V - 0.66 0.63 0.71 15 2257 8 1 5 2 9
2YIE_X - 0.73 0.67 0.80 8 1368 3 1 1 1 4
2YIE_Z - 0.43 0.42 0.45 5 1529 6 3 3 0 7
2ZY6_A - 0.58 0.58 0.58 7 691 5 0 5 0 5
2ZZM_B 0.53 0.47 0.60 15 3461 10 2 8 0 17
2ZZN_D 0.82 0.78 0.88 21 2461 3 0 3 0 6
3A2K_C 0.44 0.43 0.46 12 2900 14 2 12 0 16
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.39 0.39 0.41 11 2674 17 4 12 1 17
3AM1_B - 0.68 0.63 0.73 22 3210 8 1 7 0 13
3AMU_B 0.65 0.59 0.73 16 2981 8 0 6 2 11
3DW4_A - -0.02 0.00 0.00 0 345 6 0 6 0 10
3G4S_9 0.30 0.25 0.38 14 7344 23 1 22 0 43
3GCA_A - 0.49 0.29 0.83 5 522 1 0 1 0 12
3GX2_A 0.77 0.63 0.96 25 4345 2 0 1 1 15
3HAY_E - 0.91 0.83 1.00 15 2263 6 0 0 6 3
3HJW_D - 0.94 0.89 1.00 16 1637 2 0 0 2 2
3IAB_R - 0.86 0.86 0.86 12 1021 4 1 1 2 2
3ID5_D - 0.49 0.33 0.75 3 492 6 0 1 5 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.80 0.67 0.96 22 4255 1 0 1 0 11
3IYQ_A 0.34 0.37 0.32 35 60615 80 21 55 4 59
3IZ4_A 0.52 0.45 0.61 60 70777 44 4 35 5 72
3IZF_C 0.68 0.61 0.77 33 6860 10 1 9 0 21
3J0L_1 - 0.73 0.58 0.92 11 1213 2 0 1 1 8
3J0L_2 - 0.25 0.24 0.28 8 6187 26 0 21 5 25
3J0L_g - 0.00 0.00 0.00 0 464 1 1 0 0 4
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.50 0.44 0.58 7 1116 5 2 3 0 9
3J0L_7 - -0.01 0.00 0.00 0 1218 7 0 7 0 17
3J0L_h - 0.75 0.65 0.88 28 6073 6 0 4 2 15
3J16_L 0.46 0.40 0.55 12 2753 10 1 9 0 18
3J20_1 0.96 0.91 1.00 21 2905 4 0 0 4 2
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J2C_O - 0.79 0.67 0.93 42 10251 4 0 3 1 21
3J2L_3 0.56 0.49 0.65 26 7835 16 0 14 2 27
3JYV_7 -0.01 0.00 0.00 0 2830 20 0 20 0 32
3JYX_3 0.28 0.30 0.27 8 6298 23 8 14 1 19
3JYX_4 0.20 0.21 0.20 7 12211 35 6 22 7 26
3KTW_C - 0.44 0.40 0.50 17 4526 18 2 15 1 26
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.81 0.72 0.92 44 9132 5 0 4 1 17
3NKB_B - 0.54 0.50 0.59 13 1994 9 0 9 0 13
3NMU_E - 0.71 0.50 1.00 3 558 3 0 0 3 3
3NPB_A 0.76 0.70 0.84 32 6983 8 1 5 2 14
3O58_3 0.28 0.26 0.31 9 12374 20 3 17 0 26
3O58_2 0.78 0.76 0.81 29 7224 10 2 5 3 9
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 1 0 0 1 1
3PDR_A 0.69 0.60 0.80 43 12826 13 0 11 2 29
3R4F_A - 0.79 0.76 0.83 19 2122 4 1 3 0 6
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.73 0.59 0.91 20 2189 2 1 1 0 14
3SD1_A 0.57 0.48 0.69 20 3887 9 2 7 0 22
3SIU_F - 0.74 0.64 0.88 7 370 1 0 1 0 4
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.59 0.46 0.77 17 3138 5 0 5 0 20
3UZL_B 0.70 0.54 0.91 20 3548 2 0 2 0 17
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.89 0.80 1.00 32 4721 1 0 0 1 8
3ZEX_D 0.73 0.67 0.80 33 6980 8 1 7 0 16
3ZEX_G - 0.28 0.24 0.33 18 16416 41 2 35 4 56
3ZEX_E - 0.00 0.00 0.00 0 21889 58 4 52 2 77
4A1C_3 0.66 0.57 0.78 31 7100 9 1 8 0 23
4A1C_2 0.16 0.15 0.17 5 11751 33 5 20 8 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.44 0.36 0.56 15 4344 13 1 11 1 27
4ATO_G - 0.44 0.40 0.50 4 520 4 0 4 0 6
4ENB_A 0.73 0.58 0.92 11 1263 1 1 0 0 8
4ENC_A 0.73 0.58 0.92 11 1314 1 1 0 0 8
4FRG_B 0.68 0.56 0.82 18 3464 4 1 3 0 14
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1518
Total TN 478227
Total FP 905
Total FP CONTRA 82
Total FP INCONS 736
Total FP COMP 87
Total FN 1747
Total Scores
MCC 0.547
Average MCC ± 95% Confidence Intervals 0.621 ± 0.054
Sensitivity 0.465
Positive Predictive Value 0.650
Nr of predictions 129

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.37 0.36 0.40 4 396 6 0 6 0 7
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.49 0.25 1.00 5 625 0 0 0 0 15
2KGP_A - -0.02 0.00 0.00 0 296 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.65 0.53 0.81 21 5125 7 0 5 2 19
2KU0_A - -0.02 0.00 0.00 0 694 9 0 9 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_B 0.68 0.56 0.82 14 2128 3 0 3 0 11
2L1F_A 0.66 0.54 0.81 13 2064 3 0 3 0 11
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LA5_A - 0.46 0.26 0.83 5 624 1 0 1 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.31 0.28 0.34 11 6073 21 3 18 0 28
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - -0.03 0.00 0.00 0 186 4 0 4 0 7
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WW9_D - 0.19 0.12 0.33 3 1944 6 0 6 0 23
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4533 27 8 19 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5122 29 1 28 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.63 0.50 0.80 12 2263 4 0 3 1 12
2YIE_X - 0.36 0.33 0.40 4 1368 6 2 4 0 8
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.21 0.19 0.24 6 3461 19 0 19 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.89 0.79 1.00 30 4156 0 0 0 0 8
3AKZ_H 0.67 0.57 0.80 16 2681 5 1 3 1 12
3AM1_B - 0.84 0.71 1.00 25 3215 0 0 0 0 10
3AMU_B 0.64 0.56 0.75 15 2983 7 0 5 2 12
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.30 0.23 0.39 13 7348 20 1 19 0 44
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.50 0.40 0.64 16 4346 10 0 9 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.51 0.50 0.53 9 1636 8 0 8 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.27 0.21 0.35 7 4258 13 1 12 0 26
3IYQ_A 0.29 0.29 0.29 27 60634 71 13 52 6 67
3IZ4_A 0.36 0.31 0.43 41 70780 59 7 48 4 91
3IZF_C 0.69 0.56 0.86 30 6868 5 0 5 0 24
3J0L_1 - 0.28 0.21 0.40 4 1215 6 1 5 0 15
3J0L_2 - 0.38 0.36 0.41 12 6187 18 3 14 1 21
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_7 - 0.51 0.41 0.64 7 1214 4 0 4 0 10
3J0L_h - 0.38 0.28 0.52 12 6082 11 0 11 0 31
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.57 0.45 0.73 24 7842 12 1 8 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_3 0.60 0.56 0.65 15 6305 11 4 4 3 12
3JYX_4 0.10 0.09 0.12 3 12220 33 2 21 10 30
3KTW_C - 0.36 0.28 0.48 12 4535 13 3 10 0 31
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.28 0.23 0.35 14 9140 26 0 26 0 47
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.41 0.17 1.00 1 560 3 0 0 3 5
3NPB_A 0.61 0.50 0.74 23 6990 9 0 8 1 23
3O58_3 0.09 0.09 0.10 3 12373 35 5 22 8 32
3O58_2 0.47 0.42 0.53 16 7230 16 3 11 2 22
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.19 0.17 0.24 7 3887 22 1 21 0 35
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.53 0.41 0.71 15 3549 6 1 5 0 22
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.67 0.58 0.79 23 4724 7 0 6 1 17
3ZEX_D 0.55 0.45 0.69 22 6989 10 0 10 0 27
3ZEX_G - 0.30 0.23 0.39 17 16427 27 2 25 0 57
3ZEX_E - 0.08 0.06 0.11 5 21900 40 1 39 0 72
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.28 0.24 0.33 8 11757 28 0 16 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28
4ATO_G - 0.32 0.30 0.38 3 520 5 1 4 0 7
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.69 0.47 1.00 9 1317 0 0 0 0 10
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4HXH_A - 1.00 1.00 1.00 6 319 0 0 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.