CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Vsfold5 [.zip] - may take several seconds...


Overview

Metric Contrafold Vsfold5
MCC 0.648 > 0.510
Average MCC ± 95% Confidence Intervals 0.706 ± 0.048 > 0.601 ± 0.058
Sensitivity 0.580 > 0.441
Positive Predictive Value 0.730 > 0.596
Total TP 1861 > 1415
Total TN 466016 < 466193
Total FP 814 < 1045
Total FP CONTRA 101 < 110
Total FP INCONS 589 < 849
Total FP COMP 124 > 86
Total FN 1349 < 1795
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Vsfold5).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1861
Total TN 466016
Total FP 814
Total FP CONTRA 101
Total FP INCONS 589
Total FP COMP 124
Total FN 1349
Total Scores
MCC 0.648
Average MCC ± 95% Confidence Intervals 0.706 ± 0.048
Sensitivity 0.580
Positive Predictive Value 0.730
Nr of predictions 127

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.90 0.90 0.90 9 396 2 0 1 1 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2KFC_A - 0.45 0.25 0.83 5 624 1 0 1 0 15
2KGP_A - 1.00 1.00 1.00 9 291 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 367 0 0 0 0 0
2KPV_A - 1.00 1.00 1.00 13 548 0 0 0 0 0
2KRL_A - 0.76 0.60 0.96 24 5126 5 0 1 4 16
2KU0_A - 0.55 0.44 0.70 7 693 3 0 3 0 9
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2KXM_A - 0.89 0.80 1.00 8 343 0 0 0 0 2
2KZL_A - 0.75 0.74 0.78 14 1467 4 2 2 0 5
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L2K_A - 0.94 0.89 1.00 17 844 0 0 0 0 2
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.94 0.88 1.00 30 2455 0 0 0 0 4
2L5Z_A - 0.86 0.75 1.00 9 316 0 0 0 0 3
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LA5_A - 0.39 0.26 0.63 5 622 3 1 2 0 14
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A 0.45 0.35 0.58 7 1528 5 2 3 0 13
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.84 0.79 0.89 31 6070 6 0 4 2 8
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 1.00 1.00 1.00 7 183 0 0 0 0 0
2RRC_A - 0.83 0.70 1.00 7 224 0 0 0 0 3
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2WW9_E - 0.00 0.00 0.00 0 561 0 0 0 0 14
2WW9_D - 0.39 0.23 0.67 6 1944 3 2 1 0 20
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WWQ_V 0.78 0.68 0.90 19 2905 4 0 2 2 9
2XKV_B 0.51 0.50 0.53 10 4541 25 0 9 16 10
2XQD_Y 0.78 0.70 0.86 19 2828 3 0 3 0 8
2XXA_G 0.13 0.12 0.15 5 5117 29 1 28 0 37
2Y8W_B - 1.00 1.00 1.00 6 184 3 0 0 3 0
2Y9C_V - 0.66 0.63 0.71 15 2257 8 1 5 2 9
2YIE_X - 0.73 0.67 0.80 8 1368 3 1 1 1 4
2YIE_Z - 0.43 0.42 0.45 5 1529 6 3 3 0 7
2ZY6_A - 0.58 0.58 0.58 7 691 5 0 5 0 5
2ZZM_B 0.53 0.47 0.60 15 3461 10 2 8 0 17
2ZZN_D 0.82 0.78 0.88 21 2461 3 0 3 0 6
3A2K_C 0.44 0.43 0.46 12 2900 14 2 12 0 16
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3ADB_C - 0.92 0.84 1.00 32 4154 0 0 0 0 6
3AKZ_H 0.39 0.39 0.41 11 2674 17 4 12 1 17
3AM1_B - 0.68 0.63 0.73 22 3210 8 1 7 0 13
3AMU_B 0.65 0.59 0.73 16 2981 8 0 6 2 11
3DW4_A - -0.02 0.00 0.00 0 345 6 0 6 0 10
3G4S_9 0.30 0.25 0.38 14 7344 23 1 22 0 43
3GCA_A - 0.49 0.29 0.83 5 522 1 0 1 0 12
3GX2_A 0.77 0.63 0.96 25 4345 2 0 1 1 15
3HAY_E - 0.91 0.83 1.00 15 2263 6 0 0 6 3
3HJW_D - 0.94 0.89 1.00 16 1637 2 0 0 2 2
3IAB_R - 0.86 0.86 0.86 12 1021 4 1 1 2 2
3ID5_D - 0.49 0.33 0.75 3 492 6 0 1 5 6
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IWN_A 0.80 0.67 0.96 22 4255 1 0 1 0 11
3IYQ_A 0.34 0.37 0.32 35 60615 80 21 55 4 59
3IZ4_A 0.52 0.45 0.61 60 70777 44 4 35 5 72
3IZF_C 0.68 0.61 0.77 33 6860 10 1 9 0 21
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_1 - 0.73 0.58 0.92 11 1213 2 0 1 1 8
3J0L_h - 0.75 0.65 0.88 28 6073 6 0 4 2 15
3J0L_2 - 0.25 0.24 0.28 8 6187 26 0 21 5 25
3J0L_7 - -0.01 0.00 0.00 0 1218 7 0 7 0 17
3J0L_g - 0.00 0.00 0.00 0 464 1 1 0 0 4
3J0L_a - 0.50 0.44 0.58 7 1116 5 2 3 0 9
3J16_L 0.46 0.40 0.55 12 2753 10 1 9 0 18
3J20_0 0.44 0.40 0.50 12 2826 13 0 12 1 18
3J20_1 0.96 0.91 1.00 21 2905 4 0 0 4 2
3J2C_O - 0.79 0.67 0.93 42 10251 4 0 3 1 21
3J2L_3 0.56 0.49 0.65 26 7835 16 0 14 2 27
3JYV_7 -0.01 0.00 0.00 0 2830 20 0 20 0 32
3JYX_4 0.20 0.21 0.20 7 12211 35 6 22 7 26
3JYX_3 0.28 0.30 0.27 8 6298 23 8 14 1 19
3KTW_C - 0.44 0.40 0.50 17 4526 18 2 15 1 26
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NDB_M - 0.81 0.72 0.92 44 9132 5 0 4 1 17
3NKB_B - 0.54 0.50 0.59 13 1994 9 0 9 0 13
3NMU_E - 0.71 0.50 1.00 3 558 3 0 0 3 3
3NPB_A 0.76 0.70 0.84 32 6983 8 1 5 2 14
3O58_3 0.28 0.26 0.31 9 12374 20 3 17 0 26
3O58_2 0.78 0.76 0.81 29 7224 10 2 5 3 9
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 1 0 0 1 1
3PDR_A 0.69 0.60 0.80 43 12826 13 0 11 2 29
3R4F_A - 0.79 0.76 0.83 19 2122 4 1 3 0 6
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.73 0.59 0.91 20 2189 2 1 1 0 14
3SD1_A 0.57 0.48 0.69 20 3887 9 2 7 0 22
3SIU_F - 0.74 0.64 0.88 7 370 1 0 1 0 4
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.59 0.46 0.77 17 3138 5 0 5 0 20
3UZL_B 0.70 0.54 0.91 20 3548 2 0 2 0 17
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.89 0.80 1.00 32 4721 1 0 0 1 8
3ZEX_D 0.73 0.67 0.80 33 6980 8 1 7 0 16
3ZEX_E - 0.00 0.00 0.00 0 21889 58 4 52 2 77
4A1C_3 0.66 0.57 0.78 31 7100 9 1 8 0 23
4A1C_2 0.16 0.15 0.17 5 11751 33 5 20 8 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.44 0.36 0.56 15 4344 13 1 11 1 27
4ATO_G - 0.44 0.40 0.50 4 520 4 0 4 0 6
4ENB_A 0.73 0.58 0.92 11 1263 1 1 0 0 8
4ENC_A 0.73 0.58 0.92 11 1314 1 1 0 0 8
4FRG_B 0.68 0.56 0.82 18 3464 4 1 3 0 14
4FRN_A 0.65 0.56 0.77 20 5125 6 1 5 0 16

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1415
Total TN 466193
Total FP 1045
Total FP CONTRA 110
Total FP INCONS 849
Total FP COMP 86
Total FN 1795
Total Scores
MCC 0.510
Average MCC ± 95% Confidence Intervals 0.601 ± 0.058
Sensitivity 0.441
Positive Predictive Value 0.596
Nr of predictions 127

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 395 0 0 0 0 0
2K63_A - 0.95 0.90 1.00 9 397 0 0 0 0 1
2K66_A - 0.95 0.90 1.00 9 222 0 0 0 0 1
2KD8_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
2KDQ_B 0.90 0.82 1.00 9 397 0 0 0 0 2
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KEZ_A - 0.70 0.50 1.00 5 271 0 0 0 0 5
2KFC_A - 0.48 0.35 0.70 7 620 3 0 3 0 13
2KGP_A - 0.81 0.67 1.00 6 294 1 0 0 1 3
2KMJ_A - 0.95 0.91 1.00 10 368 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 549 0 0 0 0 1
2KRL_A - 0.57 0.50 0.65 20 5120 11 5 6 0 20
2KU0_A - -0.02 0.00 0.00 0 692 11 0 11 0 16
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KX8_A 0.91 0.83 1.00 15 846 0 0 0 0 3
2KXM_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
2KZL_A - 0.86 0.74 1.00 14 1471 0 0 0 0 5
2L1F_A 0.69 0.58 0.82 14 2063 3 0 3 0 10
2L1F_B 0.70 0.60 0.83 15 2127 3 0 3 0 10
2L2K_A - 0.89 0.79 1.00 15 846 0 0 0 0 4
2L3C_B - 0.91 0.82 1.00 14 547 0 0 0 0 3
2L3E_A - 0.96 0.92 1.00 12 583 1 0 0 1 1
2L3J_B 0.87 0.76 1.00 26 2459 0 0 0 0 8
2L5Z_A - 0.60 0.50 0.75 6 317 2 0 2 0 6
2L94_A 0.95 0.90 1.00 18 972 0 0 0 0 2
2LA5_A - -0.02 0.00 0.00 0 623 7 0 7 0 19
2LBS_A - 1.00 1.00 1.00 14 482 0 0 0 0 0
2LC8_A -0.01 0.00 0.00 0 1527 13 0 13 0 20
2LDL_A - 0.85 0.73 1.00 8 343 1 0 0 1 3
2LDT_A - 0.85 0.73 1.00 11 454 0 0 0 0 4
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2LKR_A - 0.27 0.23 0.32 9 6077 19 2 17 0 30
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
2RP0_A - 0.64 0.42 1.00 5 346 0 0 0 0 7
2RPT_A - 0.70 0.71 0.71 5 183 2 0 2 0 2
2RRC_A - 0.70 0.50 1.00 5 226 0 0 0 0 5
2WRQ_Y 0.53 0.53 0.53 9 2833 12 5 3 4 8
2WW9_E - -0.01 0.00 0.00 0 556 5 0 5 0 14
2WW9_D - 0.15 0.12 0.21 3 1939 11 1 10 0 23
2WW9_F - 0.59 0.60 0.60 6 290 4 0 4 0 4
2WWQ_V 0.64 0.50 0.82 14 2909 4 0 3 1 14
2XKV_B -0.01 0.00 0.00 0 4528 32 12 20 0 20
2XQD_Y 0.86 0.74 1.00 20 2830 0 0 0 0 7
2XXA_G -0.01 0.00 0.00 0 5120 31 2 29 0 42
2Y8W_B - 1.00 1.00 1.00 6 184 1 0 0 1 0
2Y9C_V - 0.61 0.54 0.68 13 2259 7 1 5 1 11
2YIE_X - 0.30 0.33 0.29 4 1364 10 2 8 0 8
2YIE_Z - -0.01 0.00 0.00 0 1529 11 3 8 0 12
2ZY6_A - 0.58 0.58 0.58 7 691 5 1 4 0 5
2ZZM_B 0.19 0.19 0.21 6 3458 22 1 21 0 26
2ZZN_D 0.86 0.78 0.95 21 2463 1 0 1 0 6
3A2K_C 0.84 0.71 1.00 20 2906 0 0 0 0 8
3A3A_A 0.85 0.73 1.00 27 3628 0 0 0 0 10
3ADB_C - 0.67 0.53 0.87 20 4163 3 0 3 0 18
3AKZ_H 0.84 0.71 1.00 20 2681 0 0 0 0 8
3AM1_B - 0.78 0.71 0.86 25 3211 4 1 3 0 10
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3DW4_A - 0.70 0.50 1.00 5 346 0 0 0 0 5
3G4S_9 0.08 0.07 0.11 4 7344 33 0 33 0 53
3GCA_A - 0.54 0.29 1.00 5 523 0 0 0 0 12
3GX2_A 0.51 0.40 0.67 16 4347 9 0 8 1 24
3HAY_E - 0.91 0.83 1.00 15 2263 3 0 0 3 3
3HJW_D - 0.48 0.50 0.47 9 1634 10 0 10 0 9
3IAB_R - 0.92 0.86 1.00 12 1023 0 0 0 0 2
3ID5_D - 0.44 0.33 0.60 3 491 4 0 2 2 6
3IVN_B 0.76 0.58 1.00 18 2328 0 0 0 0 13
3IWN_A 0.25 0.21 0.30 7 4255 16 1 15 0 26
3IYQ_A 0.33 0.31 0.35 29 60642 61 15 40 6 65
3IZ4_A 0.29 0.24 0.36 32 70787 62 8 49 5 100
3IZF_C 0.70 0.56 0.88 30 6869 4 0 4 0 24
3J0L_8 - 0.70 0.50 1.00 4 186 0 0 0 0 4
3J0L_1 - 0.27 0.21 0.36 4 1214 7 1 6 0 15
3J0L_h - 0.18 0.14 0.24 6 6080 19 1 18 0 37
3J0L_2 - 0.35 0.33 0.37 11 6186 21 3 16 2 22
3J0L_7 - -0.01 0.00 0.00 0 1212 13 0 13 0 17
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J16_L 0.82 0.67 1.00 20 2755 0 0 0 0 10
3J20_0 0.67 0.57 0.81 17 2829 5 1 3 1 13
3J20_1 0.71 0.70 0.73 16 2904 6 0 6 0 7
3J2C_O - 0.30 0.24 0.39 15 10258 24 0 23 1 48
3J2L_3 0.56 0.45 0.71 24 7841 13 1 9 3 29
3JYV_7 -0.01 0.00 0.00 0 2831 19 0 19 0 32
3JYX_4 0.31 0.30 0.31 10 12214 32 3 19 10 23
3JYX_3 0.17 0.15 0.20 4 6308 18 4 12 2 23
3KTW_C - 0.38 0.30 0.50 13 4534 13 3 10 0 30
3LA5_A -0.01 0.00 0.00 0 2469 16 0 16 0 34
3NDB_M - 0.06 0.05 0.08 3 9144 33 1 32 0 58
3NKB_B - 0.59 0.54 0.67 14 1995 7 0 7 0 12
3NMU_E - 0.20 0.17 0.25 1 557 5 0 3 2 5
3NPB_A 0.57 0.46 0.72 21 6992 9 1 7 1 25
3O58_3 0.39 0.37 0.41 13 12371 28 7 12 9 22
3O58_2 0.45 0.42 0.48 16 7227 19 3 14 2 22
3OVB_D - 1.00 1.00 1.00 11 584 1 0 0 1 0
3OVS_D - 0.96 0.92 1.00 12 549 0 0 0 0 1
3P22_G - 0.96 0.92 1.00 11 730 0 0 0 0 1
3PDR_A 0.57 0.44 0.74 32 12837 13 0 11 2 40
3R4F_A - 0.94 0.88 1.00 22 2123 0 0 0 0 3
3R9X_C - 0.84 0.80 0.89 8 586 2 0 1 1 2
3RKF_A 0.75 0.65 0.88 22 2186 3 0 3 0 12
3SD1_A 0.11 0.10 0.15 4 3890 22 0 22 0 38
3SIU_F - 0.73 0.55 1.00 6 372 0 0 0 0 5
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.16 0.14 0.20 5 3545 20 1 19 0 32
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
3W3S_B 0.76 0.70 0.82 28 4719 7 1 5 1 12
3ZEX_D 0.08 0.06 0.11 3 6994 24 0 24 0 46
3ZEX_E - 0.07 0.06 0.08 5 21886 54 5 49 0 72
4A1C_3 0.26 0.22 0.32 12 7103 25 2 23 0 42
4A1C_2 0.24 0.24 0.24 8 11748 37 3 22 12 25
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.18 0.14 0.25 6 4347 19 1 17 1 36
4ATO_G - 0.56 0.60 0.55 6 517 5 1 4 0 4
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.56 0.47 0.68 15 3464 7 1 6 0 17
4FRN_A 0.13 0.11 0.17 4 5128 19 2 17 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.