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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of CMfinder(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & CMfinder(20) [.zip] - may take several seconds...


Overview

Metric Cylofold CMfinder(20)
MCC 0.631 > 0.546
Average MCC ± 95% Confidence Intervals 0.650 ± 0.182 > 0.560 ± 0.222
Sensitivity 0.518 > 0.366
Positive Predictive Value 0.773 < 0.822
Total TP 85 > 60
Total TN 21122 < 21159
Total FP 28 > 15
Total FP CONTRA 1 = 1
Total FP INCONS 24 > 12
Total FP COMP 3 > 2
Total FN 79 < 104
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

  2. Comparison of performance of Cylofold and CMfinder(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

  4. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and CMfinder(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and CMfinder(20)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 85
Total TN 21122
Total FP 28
Total FP CONTRA 1
Total FP INCONS 24
Total FP COMP 3
Total FN 79
Total Scores
MCC 0.631
Average MCC ± 95% Confidence Intervals 0.650 ± 0.182
Sensitivity 0.518
Positive Predictive Value 0.773
Nr of predictions 4

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.66 0.57 0.77 17 2828 6 1 4 1 13
3J2L_3 0.56 0.43 0.72 23 7843 11 0 9 2 30
3ZEX_D 0.58 0.49 0.69 24 6986 11 0 11 0 25
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11

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Performance of CMfinder(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(20)

Total Base Pair Counts
Total TP 60
Total TN 21159
Total FP 15
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 2
Total FN 104
Total Scores
MCC 0.546
Average MCC ± 95% Confidence Intervals 0.560 ± 0.222
Sensitivity 0.366
Positive Predictive Value 0.822
Nr of predictions 4

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2. Individual counts for CMfinder(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3J20_0 0.75 0.57 1.00 17 2833 1 0 0 1 13
3J2L_3 0.45 0.32 0.63 17 7848 11 1 9 1 36
3ZEX_D 0.58 0.39 0.86 19 6999 3 0 3 0 30
4FRG_B 0.47 0.22 1.00 7 3479 0 0 0 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.