CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of RNAalifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & RNAalifold(seed) [.zip] - may take several seconds...


Overview

Metric Cylofold RNAalifold(seed)
MCC 0.592 > 0.589
Average MCC ± 95% Confidence Intervals 0.637 ± 0.145 > 0.545 ± 0.113
Sensitivity 0.506 > 0.398
Positive Predictive Value 0.700 < 0.878
Total TP 273 > 215
Total TN 68709 < 68854
Total FP 139 > 35
Total FP CONTRA 17 > 3
Total FP INCONS 100 > 27
Total FP COMP 22 > 5
Total FN 267 < 325
P-value 0.068096332007

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Performance plots


  1. Comparison of performance of Cylofold and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and RNAalifold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and RNAalifold(seed)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 273
Total TN 68709
Total FP 139
Total FP CONTRA 17
Total FP INCONS 100
Total FP COMP 22
Total FN 267
Total Scores
MCC 0.592
Average MCC ± 95% Confidence Intervals 0.637 ± 0.145
Sensitivity 0.506
Positive Predictive Value 0.700
Nr of predictions 17

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2L1F_A 0.91 0.83 1.00 20 2060 0 0 0 0 4
2L1F_B 0.92 0.84 1.00 21 2124 0 0 0 0 4
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
2XKV_B 0.38 0.40 0.36 8 4538 23 7 7 9 12
2XXA_G 0.10 0.10 0.11 4 5115 32 1 31 0 38
3O58_3 0.36 0.34 0.38 12 12371 29 5 15 9 23
3PDR_A 0.72 0.54 0.95 39 12839 4 0 2 2 33
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.62 0.50 0.78 21 3889 6 0 6 0 21
3W3S_B 0.44 0.38 0.52 15 4724 15 0 14 1 25
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4
4FRG_B 0.81 0.66 1.00 21 3465 0 0 0 0 11
4FRN_A 0.20 0.14 0.31 5 5135 11 2 9 0 31

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Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 215
Total TN 68854
Total FP 35
Total FP CONTRA 3
Total FP INCONS 27
Total FP COMP 5
Total FN 325
Total Scores
MCC 0.589
Average MCC ± 95% Confidence Intervals 0.545 ± 0.113
Sensitivity 0.398
Positive Predictive Value 0.878
Nr of predictions 17

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 0.00 0.00 0.00 0 861 0 0 0 0 18
2L1F_A 0.67 0.58 0.78 14 2062 4 0 4 0 10
2L1F_B 0.64 0.56 0.74 14 2126 5 0 5 0 11
2L94_A 0.59 0.40 0.89 8 981 1 0 1 0 12
2LC8_A -0.01 0.00 0.00 0 1528 12 0 12 0 20
2XKV_B 0.59 0.35 1.00 7 4553 2 0 0 2 13
2XXA_G 0.46 0.21 1.00 9 5142 0 0 0 0 33
3O58_3 0.51 0.26 1.00 9 12394 0 0 0 0 26
3PDR_A 0.68 0.46 1.00 33 12847 1 0 0 1 39
3RKF_A 0.63 0.47 0.84 16 2192 3 1 2 0 18
3SD1_A 0.58 0.40 0.85 17 3896 3 1 2 0 25
3W3S_B 0.67 0.45 1.00 18 4735 1 0 0 1 22
4AOB_A 0.72 0.52 1.00 22 4349 1 0 0 1 20
4ENB_A 0.56 0.32 1.00 6 1269 0 0 0 0 13
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13
4FRG_B 0.73 0.53 1.00 17 3469 0 0 0 0 15
4FRN_A 0.69 0.53 0.90 19 5130 2 1 1 0 17

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.