CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of IPknot - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for IPknot & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric IPknot RNASampler(seed)
MCC 0.547 > 0.447
Average MCC ± 95% Confidence Intervals 0.534 ± 0.269 > 0.421 ± 0.287
Sensitivity 0.416 > 0.299
Positive Predictive Value 0.724 > 0.673
Total TP 92 > 66
Total TN 38270 < 38299
Total FP 44 < 45
Total FP CONTRA 6 > 1
Total FP INCONS 29 < 31
Total FP COMP 9 < 13
Total FN 129 < 155
P-value 0.0

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Performance plots


  1. Comparison of performance of IPknot and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 92
Total TN 38270
Total FP 44
Total FP CONTRA 6
Total FP INCONS 29
Total FP COMP 9
Total FN 129
Total Scores
MCC 0.547
Average MCC ± 95% Confidence Intervals 0.534 ± 0.269
Sensitivity 0.416
Positive Predictive Value 0.724
Nr of predictions 6

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.40 0.30 0.55 6 1529 5 1 4 0 14
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.61 0.48 0.80 20 3891 5 0 5 0 22
3W3S_B 0.85 0.75 0.97 30 4722 2 0 1 1 10
3ZEX_C 0.41 0.21 0.79 11 14182 6 1 2 3 41
4A1C_2 0.17 0.15 0.19 5 11755 26 4 17 5 28

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 66
Total TN 38299
Total FP 45
Total FP CONTRA 1
Total FP INCONS 31
Total FP COMP 13
Total FN 155
Total Scores
MCC 0.447
Average MCC ± 95% Confidence Intervals 0.421 ± 0.287
Sensitivity 0.299
Positive Predictive Value 0.673
Nr of predictions 6

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
3W3S_B 0.55 0.30 1.00 12 4741 1 0 0 1 28
3ZEX_C 0.32 0.19 0.53 10 14177 13 1 8 4 42
4A1C_2 0.31 0.24 0.40 8 11761 20 0 12 8 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.