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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & Mastr(20) [.zip] - may take several seconds...


Overview

Metric MXScarna(20) Mastr(20)
MCC 0.624 > 0.514
Average MCC ± 95% Confidence Intervals 0.637 ± 0.064 > 0.492 ± 0.109
Sensitivity 0.518 > 0.339
Positive Predictive Value 0.756 < 0.784
Total TP 676 > 443
Total TN 247566 < 247895
Total FP 304 > 155
Total FP CONTRA 38 > 15
Total FP INCONS 180 > 107
Total FP COMP 86 > 33
Total FN 629 < 862
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MXScarna(20) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Mastr(20)).

  2. Comparison of performance of MXScarna(20) and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Mastr(20)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Mastr(20)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Mastr(20)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Mastr(20)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Mastr(20)).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 676
Total TN 247566
Total FP 304
Total FP CONTRA 38
Total FP INCONS 180
Total FP COMP 86
Total FN 629
Total Scores
MCC 0.624
Average MCC ± 95% Confidence Intervals 0.637 ± 0.064
Sensitivity 0.518
Positive Predictive Value 0.756
Nr of predictions 34

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2L94_A 0.73 0.70 0.78 14 972 4 0 4 0 6
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2XKV_B 0.45 0.20 1.00 4 4556 3 0 0 3 16
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.80 0.71 0.91 30 5118 4 0 3 1 12
3A2K_C 0.66 0.57 0.76 16 2905 6 1 4 1 12
3AMU_B 0.86 0.74 1.00 20 2983 2 0 0 2 7
3G4S_9 0.52 0.40 0.68 23 7347 13 1 10 2 34
3GX2_A 0.70 0.58 0.85 23 4344 5 0 4 1 17
3IVN_B 0.74 0.58 0.95 18 2327 1 1 0 0 13
3IZ4_A 0.51 0.41 0.64 54 70791 32 7 24 1 78
3IZF_C 0.67 0.59 0.76 32 6861 11 1 9 1 22
3J20_0 0.82 0.67 1.00 20 2830 0 0 0 0 10
3J20_1 0.93 0.87 1.00 20 2906 0 0 0 0 3
3J2L_3 0.54 0.42 0.71 22 7844 11 1 8 2 31
3JYV_7 0.79 0.63 1.00 20 2830 0 0 0 0 12
3JYX_4 0.33 0.30 0.37 10 12219 32 2 15 15 23
3JYX_3 0.55 0.52 0.58 14 6304 23 0 10 13 13
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.69 0.59 0.82 27 6988 9 1 5 3 19
3O58_2 0.74 0.74 0.74 28 7222 13 4 6 3 10
3O58_3 0.52 0.40 0.67 14 12382 17 2 5 10 21
3PDR_A 0.71 0.57 0.89 41 12834 9 0 5 4 31
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.63 0.55 0.74 23 3885 8 2 6 0 19
3ZEX_C 0.31 0.21 0.46 11 14172 13 2 11 0 41
3ZEX_D 0.68 0.63 0.74 31 6979 11 2 9 0 18
4A1C_3 0.64 0.56 0.75 30 7100 11 2 8 1 24
4A1C_2 0.18 0.15 0.21 5 11757 36 2 17 17 28
4AOB_A 0.62 0.55 0.72 23 4339 10 0 9 1 19
4ENB_A 0.26 0.11 0.67 2 1272 1 0 1 0 17
4ENC_A 0.60 0.37 1.00 7 1319 0 0 0 0 12
4FRG_B 0.55 0.44 0.70 14 3466 6 2 4 0 18

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 443
Total TN 247895
Total FP 155
Total FP CONTRA 15
Total FP INCONS 107
Total FP COMP 33
Total FN 862
Total Scores
MCC 0.514
Average MCC ± 95% Confidence Intervals 0.492 ± 0.109
Sensitivity 0.339
Positive Predictive Value 0.784
Nr of predictions 34

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2L94_A 0.87 0.80 0.94 16 973 1 0 1 0 4
2WRQ_Y 0.57 0.59 0.56 10 2832 12 5 3 4 7
2XKV_B 0.45 0.20 1.00 4 4556 3 0 0 3 16
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.41 0.17 1.00 7 5144 0 0 0 0 35
3A2K_C 0.72 0.61 0.85 17 2906 3 0 3 0 11
3AMU_B 0.77 0.59 1.00 16 2987 1 0 0 1 11
3G4S_9 0.48 0.32 0.75 18 7357 8 1 5 2 39
3GX2_A 0.39 0.28 0.55 11 4351 10 0 9 1 29
3IVN_B 0.78 0.65 0.95 20 2325 1 1 0 0 11
3IZ4_A 0.00 0.00 0.00 0 70876 0 0 0 0 132
3IZF_C 0.73 0.63 0.85 34 6863 7 1 5 1 20
3J20_0 0.84 0.70 1.00 21 2829 1 0 0 1 9
3J20_1 0.25 0.22 0.29 5 2909 12 0 12 0 18
3J2L_3 0.34 0.25 0.48 13 7848 16 1 13 2 40
3JYV_7 0.81 0.66 1.00 21 2829 0 0 0 0 11
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.56 0.56 0.58 15 6302 23 1 10 12 12
3LA5_A 0.76 0.59 1.00 20 2465 0 0 0 0 14
3NPB_A 0.30 0.24 0.39 11 6993 18 1 16 1 35
3O58_2 0.76 0.76 0.76 29 7222 12 3 6 3 9
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.70 0.50 1.00 17 2194 0 0 0 0 17
3SD1_A 0.61 0.50 0.75 21 3888 7 1 6 0 21
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
3ZEX_D 0.80 0.71 0.90 35 6982 4 0 4 0 14
4A1C_3 0.70 0.59 0.84 32 7102 7 0 6 1 22
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.39 0.26 0.58 11 4352 9 0 8 1 31
4ENB_A 0.39 0.16 1.00 3 1272 0 0 0 0 16
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.