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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(20) Murlet(seed)
MCC 0.599 > 0.463
Average MCC ± 95% Confidence Intervals 0.594 ± 0.099 > 0.469 ± 0.058
Sensitivity 0.479 > 0.250
Positive Predictive Value 0.754 < 0.863
Total TP 315 > 164
Total TN 107003 < 107231
Total FP 158 > 32
Total FP CONTRA 14 > 5
Total FP INCONS 89 > 21
Total FP COMP 55 > 6
Total FN 342 < 493
P-value 1.95070920198e-08

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Performance plots


  1. Comparison of performance of MXScarna(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Murlet(seed)).

  2. Comparison of performance of MXScarna(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Murlet(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Murlet(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Murlet(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Murlet(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Murlet(seed)).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 315
Total TN 107003
Total FP 158
Total FP CONTRA 14
Total FP INCONS 89
Total FP COMP 55
Total FN 342
Total Scores
MCC 0.599
Average MCC ± 95% Confidence Intervals 0.594 ± 0.099
Sensitivity 0.479
Positive Predictive Value 0.754
Nr of predictions 19

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2L94_A 0.73 0.70 0.78 14 972 4 0 4 0 6
2XKV_B 0.45 0.20 1.00 4 4556 3 0 0 3 16
2XXA_G 0.80 0.71 0.91 30 5118 4 0 3 1 12
3GX2_A 0.70 0.58 0.85 23 4344 5 0 4 1 17
3IVN_B 0.74 0.58 0.95 18 2327 1 1 0 0 13
3JYX_4 0.33 0.30 0.37 10 12219 32 2 15 15 23
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.69 0.59 0.82 27 6988 9 1 5 3 19
3O58_3 0.52 0.40 0.67 14 12382 17 2 5 10 21
3PDR_A 0.71 0.57 0.89 41 12834 9 0 5 4 31
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.63 0.55 0.74 23 3885 8 2 6 0 19
3ZEX_C 0.31 0.21 0.46 11 14172 13 2 11 0 41
4A1C_2 0.18 0.15 0.21 5 11757 36 2 17 17 28
4AOB_A 0.62 0.55 0.72 23 4339 10 0 9 1 19
4ENB_A 0.26 0.11 0.67 2 1272 1 0 1 0 17
4ENC_A 0.60 0.37 1.00 7 1319 0 0 0 0 12
4FRG_B 0.55 0.44 0.70 14 3466 6 2 4 0 18

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 164
Total TN 107231
Total FP 32
Total FP CONTRA 5
Total FP INCONS 21
Total FP COMP 6
Total FN 493
Total Scores
MCC 0.463
Average MCC ± 95% Confidence Intervals 0.469 ± 0.058
Sensitivity 0.250
Positive Predictive Value 0.863
Nr of predictions 19

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.52 0.27 1.00 3 403 0 0 0 0 8
2L94_A 0.59 0.40 0.89 8 981 1 0 1 0 12
2XKV_B 0.45 0.20 1.00 4 4556 2 0 0 2 16
2XXA_G 0.38 0.14 1.00 6 5145 0 0 0 0 36
3GX2_A 0.59 0.35 1.00 14 4357 1 0 0 1 26
3IVN_B 0.53 0.39 0.75 12 2330 4 2 2 0 19
3JYX_4 0.23 0.09 0.60 3 12241 4 0 2 2 30
3LA5_A 0.58 0.41 0.82 14 2468 3 1 2 0 20
3NPB_A 0.49 0.28 0.87 13 7006 2 1 1 0 33
3O58_3 0.45 0.20 1.00 7 12396 0 0 0 0 28
3PDR_A 0.44 0.19 1.00 14 12866 0 0 0 0 58
3RKF_A 0.53 0.35 0.80 12 2196 3 1 2 0 22
3SD1_A 0.47 0.26 0.85 11 3903 2 0 2 0 31
3ZEX_C 0.37 0.13 1.00 7 14189 0 0 0 0 45
4A1C_2 0.46 0.21 1.00 7 11774 0 0 0 0 26
4AOB_A 0.58 0.33 1.00 14 4357 1 0 0 1 28
4ENB_A 0.56 0.32 1.00 6 1269 0 0 0 0 13
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13
4FRG_B 0.15 0.09 0.25 3 3474 9 0 9 0 29

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.