CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Carnac(seed)
MCC 0.661 > 0.404
Average MCC ± 95% Confidence Intervals 0.650 ± 0.070 > 0.154 ± 0.103
Sensitivity 0.560 > 0.181
Positive Predictive Value 0.781 < 0.903
Total TP 979 > 316
Total TN 1275527 < 1276431
Total FP 366 > 36
Total FP CONTRA 40 > 3
Total FP INCONS 235 > 31
Total FP COMP 91 > 2
Total FN 770 < 1433
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  2. Comparison of performance of MXScarna(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  3. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  4. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  5. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

  6. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Carnac(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 979
Total TN 1275527
Total FP 366
Total FP CONTRA 40
Total FP INCONS 235
Total FP COMP 91
Total FN 770
Total Scores
MCC 0.661
Average MCC ± 95% Confidence Intervals 0.650 ± 0.070
Sensitivity 0.560
Positive Predictive Value 0.781
Nr of predictions 35

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.89 0.84 0.94 16 1111 2 0 1 1 3
2KUR_A 0.87 0.81 0.94 17 1110 1 0 1 0 4
2KUU_A 0.84 0.76 0.94 16 1111 2 0 1 1 5
2KUV_A 0.85 0.77 0.94 17 1110 1 0 1 0 5
2KUW_A 0.76 0.67 0.88 14 1112 2 0 2 0 7
2L1F_A 0.91 0.88 0.95 21 2058 1 0 1 0 3
2L1F_B 0.96 0.92 1.00 23 2122 0 0 0 0 2
2L94_A 0.57 0.55 0.61 11 972 7 0 7 0 9
2LC8_A -0.01 0.00 0.00 0 1530 12 0 10 2 20
2XKV_B 0.59 0.55 0.65 11 4543 18 0 6 12 9
2XXA_G 0.67 0.57 0.80 24 5121 7 0 6 1 18
3A3A_A 0.77 0.65 0.92 24 3629 3 0 2 1 13
3GX2_A 0.70 0.60 0.83 24 4342 6 0 5 1 16
3IVN_B 0.65 0.45 0.93 14 2331 1 1 0 0 17
3IZF_C 0.67 0.57 0.79 31 6864 9 1 7 1 23
3J20_2 0.67 0.58 0.77 366 1116289 118 14 96 8 267
3JYX_4 0.38 0.30 0.48 10 12225 21 3 8 10 23
3JYX_3 0.58 0.56 0.60 15 6303 21 1 9 11 12
3LA5_A 0.75 0.56 1.00 19 2466 0 0 0 0 15
3NPB_A 0.69 0.59 0.82 27 6988 9 2 4 3 19
3O58_3 0.45 0.34 0.60 12 12383 19 2 6 11 23
3O58_2 0.79 0.79 0.79 30 7222 10 4 4 2 8
3PDR_A 0.73 0.63 0.87 45 12828 9 2 5 2 27
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.63 0.55 0.74 23 3885 8 1 7 0 19
3W3S_B 0.69 0.60 0.80 24 4723 6 0 6 0 16
3ZEX_C 0.32 0.19 0.53 10 14177 20 2 7 11 42
4A1C_3 0.75 0.65 0.88 35 7100 5 1 4 0 19
4A1C_2 0.35 0.24 0.50 8 11765 20 1 7 12 25
4AOB_A 0.66 0.55 0.79 23 4342 7 0 6 1 19
4ENB_A 0.48 0.32 0.75 6 1267 2 0 2 0 13
4ENC_A 0.43 0.32 0.60 6 1316 4 1 3 0 13
4FRG_B 0.41 0.31 0.56 10 3468 8 2 6 0 22
4FRN_A 0.62 0.53 0.73 19 5125 7 2 5 0 17

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 316
Total TN 1276431
Total FP 36
Total FP CONTRA 3
Total FP INCONS 31
Total FP COMP 2
Total FN 1433
Total Scores
MCC 0.404
Average MCC ± 95% Confidence Intervals 0.154 ± 0.103
Sensitivity 0.181
Positive Predictive Value 0.903
Nr of predictions 35

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.00 0.00 0.00 0 1128 0 0 0 0 19
2KUR_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUU_A 0.57 0.33 1.00 7 1121 0 0 0 0 14
2KUV_A 0.64 0.41 1.00 9 1119 0 0 0 0 13
2KUW_A 0.65 0.43 1.00 9 1119 0 0 0 0 12
2L1F_A 0.00 0.00 0.00 0 2080 0 0 0 0 24
2L1F_B 0.00 0.00 0.00 0 2145 0 0 0 0 25
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
2XKV_B 0.00 0.00 0.00 0 4560 0 0 0 0 20
2XXA_G 0.00 0.00 0.00 0 5151 0 0 0 0 42
3A3A_A 0.00 0.00 0.00 0 3655 0 0 0 0 37
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3J20_2 0.59 0.40 0.88 251 1116480 36 3 31 2 382
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3W3S_B 0.00 0.00 0.00 0 4753 0 0 0 0 40
3ZEX_C 0.00 0.00 0.00 0 14196 0 0 0 0 52
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19
4FRG_B 0.00 0.00 0.00 0 3486 0 0 0 0 32
4FRN_A 0.00 0.00 0.00 0 5151 0 0 0 0 36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.